|
MMTV-Wnt1/p53
+/-
|
MMTV-Wnt1/p53
-/-
|
MMTV-Wnt1/MMTV-Neu
|
---|
With H-Ras mutations | 5 (2 with p53 LOH) | 0 | 0 |
Without H-Ras mutations | 6 (3 with p53 LOH) | 16 | 11 |
Total | 11 (5 with p53 LOH) | 16 | 11 |
- Primary tumor cDNAs (11 MMTV-Wnt1/p53
-/- samples) or DNAs (5 MMTV-Wnt1/p53
-/- samples and all of the MMTV-Wnt1/p53+/- samples) were amplified and sequenced with H-Ras-specific primers at least once in each direction, as described in Methods. Mutations were scored by the same criteria described in Table 1.