Table 2 Comparison of 50% antiviral and cell division inhibitory concentrations (IC50) and selectivity (viral versus cellular IC50) of selected antiviral drugs and THC
Inhibitor compound | KSHV IC50 (μM) | Cellular IC50 (μM) | Selectivity index (viral versus cellular IC50) |
|---|---|---|---|
Acyclovir | 75 [ref. 32] | Not done | Â |
Ganciclovir | 5.1 [ref. 32] | Not done | Â |
Foscarnet | 97 [ref. 32] | Not done | Â |
Cidofovir | 0.05 [ref. 32] | Not done | Â |
THC | 3.3 (this work) | 33 (this work) | 10 (this work) |
|  | MHV 68 IC 50 (μM) |  |  |
Acyclovir | 6 [ref. 34] 100 [ref. 33] | 182 [ref. 34] | 30 [ref. 34] |
Ganciclovir | 28 [ref. 34] | 108 [ref. 34] | 3.7 [ref. 34] |
Foscarnet | 120 [ref. 34] | 1413 [ref. 34] | 11 [ref. 34] |
Cidofovir | 0.08 [ref. 34] | 78 [ref. 34] | 10,000 [ref. 34] |
THC | 1.9 (this work) | 99 (this work) | 52 (this work) |