Ascertainment method | Subjects (unaffected relatives) | Families | LRRK2 mutations (%) | LRRK2 families (%) |
---|---|---|---|---|
Total familial Parkinson's disease cases and families studied | 903 (58) | 509 | 58 (6.4%) | 31 (6.1%) |
• Affected siblings | 730 (37) | 401 | 47 (6.4%) | 24 (6.0%) |
• Affected parent-offspring | 141 (20) | 88 | 11 (7.8%) | 7 (8.0%) |
• Other affected relatives | 32 (1) | 20 | 0 | 0 |
Randomly ascertained PD | 126 | 126 | 6 (4.8%) | 6 (4.8%) |
Controls | 197 | 197 | 0 | 0 |