Figure 5

PET and CT findings of the lower limbs of patients #1 and #3 (A) Positron emission tomography showing symmetric, bilateral, abnormally increased intra-medullary uptake of fluorodeoxyglucose in the femurs and tibiae of patient #1 approximately 4.5 years following diagnosis. (B) Computed tomography of the femurs and tibiae of patient #1 at the time of diagnosis, exhibiting periostitis as well as diffuse, irregular intra-medullary sclerosis. These bones are riddled with mixed patchy lesions of sclerotic and lytic nature encased in a markedly thickened cortex. (C) Similar findings can be observed in the computed tomography of patient #3.