| All | ARDS | P value | |
---|---|---|---|---|
(n = 404) | without statins | with statins | ||
(n = 296) | (n = 108) | |||
Age, years | 63 ± 15 | 60 ± 16 | 70 ± 11 | <0.0001 |
Male, % | 68 | 65 | 76 | 0.0533 |
Body mass index | 28 ± 7 | 28 ± 8 | 28 ± 5 | 0.4304 |
Severity of sepsis | Â | Â | Â | Â |
 Sepsis/severe sepsis, % | 36 | 32 | 48 | 0.0035 |
 Septic shock, % | 64 | 68 | 52 | 0.0035 |
Sequential Organ Failure Assessment score | 9.6 ± 3.7 | 9.9 ± 3.8 | 8.9 ± 3.4 | 0.0158 |
Acute Physiology and Chronic Health Evaluation (APACHE II) score | 22.1 ± 6.8 | 22.1 ± 7.0 | 22.1 ± 6.0 | 0.9888 |
Comorbidities, % | Â | Â | Â | Â |
 Hypertension | 56 | 48 | 78 | <0.0001 |
 History of myocardial infarction | 6 | 2 | 19 | <0.0001 |
 Chronic obstructive pulmonary disease | 18 | 18 | 20 | 0.5615 |
 Renal dysfunction | 11 | 9 | 18 | 0.0192 |
 Noninsulin-dependent diabetes mellitus | 9 | 7 | 15 | 0.0332 |
 Insulin-dependent diabetes mellitus | 11 | 9 | 19 | 0.0069 |
 Chronic liver disease | 7 | 7 | 7 | 1.0000 |
 History of cancer | 20 | 21 | 19 | 0.8891 |
 History of stroke | 5 | 4 | 11 | 0.0073 |
Recent surgical history, % | Â | Â | Â | Â |
 Elective surgery | 26 | 21 | 39 | 0.0005 |
 Emergency surgery | 54 | 56 | 49 | 0.2168 |
 No history of surgery | 20 | 23 | 12 | 0.0169 |
Site of infection, % | Â | Â | Â | 0.1339 |
 Lung | 60 | 57 | 70 |  |
 Abdomen | 23 | 25 | 17 |  |
 Bone or soft tissue | 5 | 5 | 2 |  |
 Surgical wound | 2 | 2 | 1 |  |
 Urogenital | 2 | 2 | 2 |  |
 Primary bacteremia | 6 | 5 | 7 |  |
 Other | 4 | 4 | 1 |  |
Organ support, % | Â | Â | Â | Â |
 Mechanical ventilation | 90 | 91 | 86 | 0.1393 |
 Use of vasopressor | 64 | 68 | 52 | 0.0035 |
 Renal replacement therapy | 10 | 9 | 11 | 0.5697 |
Statin drugs, % | Â | Â | Â | Â |
 Simvastatin | 23 |  | 87 |  |
 Pravastatin | 2 |  | 6 |  |
 Atorvastatin | 1 |  | 6 |  |
 Fluvastatin | 0 |  | 1 |  |