| All | Severe ARDS | P value | |
---|---|---|---|---|
(n = 114) | without statins | with statins | ||
(n = 88) | (n = 26) | |||
Age, years | 61 ± 14 | 59 ± 15 | 67 ± 10 | 0.0159 |
Male, % | 66 | 64 | 73 | 0.4822 |
Body mass index | 30 ± 8 | 30 ± 9 | 30 ± 6 | 0.5590 |
Severity of sepsis | Â | Â | Â | Â |
Sepsis/severe sepsis, % | 24 | 19 | 39 | 0.0644 |
 Septic shock, % | 76 | 81 | 62 | 0.0644 |
 Sequential Organ Failure Assessment score | 11.0 ± 3.5 | 11.2 ± 3.5 | 10.6 ± 3.4 | 0.2511 |
Acute Physiology and Chronic Health Evaluation (APACHE II) score | 23.7 ± 6.7 | 23.4 ± 6.9 | 24.5 ± 5.7 | 0.3250 |
Comorbidities, % | Â | Â | Â | Â |
 Hypertension | 58 | 51 | 81 | 0.0073 |
 History of myocardial infarction | 4 | 2 | 12 | 0.0772 |
 Chronic obstructive pulmonary disease | 18 | 19 | 15 | 0.7787 |
 Renal dysfunction | 10 | 9 | 12 | 0.7114 |
 Noninsulin-dependent diabetes mellitus | 9 | 7 | 15 | 0.2323 |
 Insulin-dependent diabetes mellitus | 12 | 13 | 12 | 1.0000 |
 Chronic liver disease | 4 | 2 | 12 | 0.0772 |
 History of cancer | 19 | 22 | 12 | 0.3964 |
 History of stroke | 6 | 2 | 19 | 0.0066 |
Recent surgical history, % | Â | Â | Â | Â |
 Elective surgery | 25 | 19 | 42 | 0.0217 |
 Emergency surgery | 46 | 49 | 35 | 0.2635 |
 No history of surgery | 30 | 32 | 23 | 0.4704 |
Site of infection, % | Â | Â | Â | 0.5675 |
 Lung | 71 | 68 | 81 |  |
 Abdomen | 11 | 13 | 4 |  |
 Bone or soft tissue | 7 | 8 | 4 |  |
 Surgical wound | 1 | 1 | 0 |  |
 Urogenital | 1 | 1 | 0 |  |
 Primary bacteremia | 7 | 6 | 12 |  |
 Other | 3 | 3 | 0 |  |
Organ support, % | Â | Â | Â | Â |
 Mechanical ventilation | 96 | 96 | 96 | 1.0000 |
 Use of vasopressor | 76 | 81 | 62 | 0.0644 |
 Renal replacement therapy | 11 | 10 | 12 | 1.0000 |
Statin drugs, % | Â | Â | Â | Â |
 Simvastatin | 20 |  | 96 |  |
 Pravastatin | 1 |  | 4 |  |