Table 4 Diagnostic performance of relative 3-hour change in troponin I concentration
Cut-off | Sensitivity | Specificity | PPV | NPV | |
|---|---|---|---|---|---|
[%] | (95 % CI) | (95 % CI) | (95 % CI) | (95 % CI) | |
Relative 3-h change in troponin I concentration | |||||
n=298, n=54 patients with MI type 1 | |||||
Absolute 3-h change threshold optimized for: | |||||
Sum of sensitivity and specificity | 0.3 | 0.85 (0.73-0.93) | 0.80 (0.75-0.85) | 0.49 (0.38-0.59) | 0.96 (0.92-0.98) |
Specificity | 40 | 0.74 (0.60-0.85) | 0.88 (0.83-0.92) | 0.58 (0.45-0.70) | 0.94 (0.90-0.97) |
Relative 3-h change in troponin I concentration and troponin I on admission above 99th percentile cut-off | |||||
n=66, n=46 patients with MI type 1 | |||||
Absolute 3-h change threshold optimized for: | |||||
Sum of sensitivity and specificity | 0.3 | 0.83 (0.69-0.92) | 0.40 (0.19-0.64) | 0.76 (0.62-0.87) | 0.50 (0.25-0.75) |
Specificity | 40 | 0.70 (0.54-0.82) | 0.75 (0.51-0.91) | 0.86 (0.71-0.95) | 0.52 (0.33-0.71) |
Relative 3-h change in troponin I concentration and troponin I on admission above unweighted optimized cut-off | |||||
n=61, n=44 patients with MI type 1 | |||||
Absolute 3-h change threshold optimized for: | |||||
Sum of sensitivity and specificity | 0.3 | 0.82 (0.67-0.92) | 0.47 (0.23-0.72) | 0.80 (0.65-0.90) | 0.50 (0.25-0.75) |
Specificity | 40 | 0.68 (0.52-0.81) | 0.88 (0.64-0.99) | 0.94 (0.79-0.99) | 0.52 (0.33-0.71) |
Relative 3-h change in troponin I concentration and troponin I on admission above specificity-optimized cut-off | |||||
n=41, n=36 patients with MI type 1 | |||||
Absolute 3-h change threshold optimized for: | |||||
Sum of sensitivity and specificity | 0.3 | 0.78 (0.61-0.90) | 0.60 (0.15-0.95) | 0.93 (0.78-0.99) | 0.27 (0.06-0.61) |
Specificity | 40 | 0.61 (0.43-0.77) | 1 (0.36-1) | 1 (0.78-1) | 0.26 (0.09-0.51) |