Within-Group | N of pairwise | Number of subjects | Meta-analysis | Heterogeneity | |||||
Hedges’ g | 95 % CI | P value | I 2 | Q | P value | ||||
Mania | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Mania– all* | 13 | 556 | 0.26 | 0.09 | 0.45 | 0.003 | 69.69 | 39.60 | 0.001 |
 Serum and plasma* | 12 | 454 | 0.30 | 0.08 | 0.44 | 0.005 | 78.48 | 18.59 | 0.001 |
 Serum | 5 | 122 | 0.39 | −0.03 | 0.81 | 0.065 | 78.48 | 18.59 | 0.001 |
Plasma* | 7 | 332 | 0.23 | 0.02 | 0.44 | 0.028 | 55.20 | 13.39 | 0.037 |
 Whole blood | 1 | 102 | 0.01 | −0.19 | 0.20 | 0.941 | N/A | N/A | N/A |
 Depression |  |  |  |  |  |  |  |  |  |
 Depression – all | 8 | 184 | 0.05 | −0.28 | 0.38 | 0.747 | 76.51 | 29.79 | 0.001 |
 Depression – except Mackin 2007 [71] | 7 | 164 | 0.15 | −0.18 | 0.49 | 0.364 | 72.84 | 22.09 | 0.001 |
 Serum | 5 | 88 | −0.12 | −0.52 | 0.29 | 0.563 | 72.15 | 14.36 | 0.006 |
 Plasma | 3 | 96 | 0.40 | −0.40 | 1.21 | 0.329 | 85.93 | 14.22 | 0.001 |
 Response | 3 | 115 | −0.06 | −0.24 | 0.18 | 0.492 | N/A | N/A | N/A |
 Non-response | 5 | 69 | 0.13 | −0.53 | 0.79 | 0.702 | 85.69 | 1.51 | 0.001 |
Moderators within-group | N of pairwise | Number of subjects | Meta-regression | Meta-regression | |||||
 |  |  | Slope | 95 % CI | P value | Intercept | Z | P value | |
Mania | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Age of BD Patients – all | 9 | 456 | −0.01 | −0.04 | 0.02 | 0.398 | 0.80 | 1.39 | 0.165 |
 % Females – all | 13 | 556 | 0.01 | −0.03 | 0.02 | 0.478 | 0.07 | 0.27 | 0.782 |
 Baseline YMRS scores | 12 | 542 | 0.01 | −0.01 | 0.02 | 0.930 | 0.20 | 0.63 | 0.522 |
 Difference in YMRS(After – Before) | 12 | 542 | −0.01 | −0.02 | 0.02 | 0.298 | 0.16 | 1.42 | 0.155 |
 % Change in YMRS Scores | 12 | 542 | −0.01 | −0.02 | 0.01 | 0.213 | 0.77 | 1.73 | 0.083 |
 Follow-up duration (weeks) | 13 | 556 | 0.01 | −0.01 | 0.03 | 0.396 | 0.19 | 1.63 | 0.101 |
 Year of publication | 13 | 556 | −0.07 | −0.12 | −0.01 | 0.011 | 141.63 | 2.53 | 0.011 |
Depression | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Age of BD patients – all | 6 | 164 | −0.01 | −0.05 | 0.02 | 0.393 | 0.50 | 0.69 | 0.489 |
 % Females – all* | 6 | 164 | 0.01 | 0.00 | 0.02 | 0.042 | −0.54 | −2.29 | 0.021 |
 % Females – excluding Mackin 2007 [71] | 5 | 144 | 0.01 | −0.01 | 0.01 | 0.555 | −0.20 | −0.68 | 0.490 |
 Baseline HDRS scores | 8 | 184 | 0.02 | −0.18 | 0.22 | 0.823 | −0.42 | −0.19 | 0.845 |
 Difference in HDRS(After – Before) | 7 | 164 | −0.02 | −0.09 | 0.06 | 0.658 | −0.01 | −0.01 | 0.988 |
 % Change in HDRS scores | 7 | 164 | 0.01 | −0.01 | 0.02 | 0.566 | −0.05 | −0.13 | 0.892 |
 Follow-up duration (weeks) | 8 | 184 | 0.01 | −0.05 | 0.07 | 0.673 | −0.04 | −0.12 | 0.899 |
 Year of publication | 8 | 184 | 0.01 | −0.11 | 0.11 | 0.987 | −1.76 | −0.01 | 0.988 |