| Control | Isoniazid | Ethambutol | Combined (adjusted for treatment) | ||||
---|---|---|---|---|---|---|---|---|
 | Unadjusted | Adjusted for baseline covariates | Unadjusted | Adjusted for baseline covariates | Unadjusted | Adjusted for baseline covariates | Unadjusted | Adjusted for baseline covariates |
No on-treatment predictors (reference) | 0.50 | 0.67 (0.57, 0.76) | 0.50 | 0.70 (0.64, 0.77) | 0.50 | 0.67 (0.61, 0.74) | 0.60 (0.57, 0.64) | 0.70 (0.66, 0.74) |
BA(0–56), daily rate of change in log10(TTP) to day 56 | 0.60 (0.52, 0.69) | 0.73 (0.66, 0.81) | 0.61 (0.55, 0.68) | 0.72 (0.65, 0.79) | 0.61 (0.55, 0.67) | 0.70 (0.64, 0.76) | 0.66 (0.62, 0.70) | 0.73 (0.69, 0.76) |
Time to culture negative status on LJ | 0.61 (0.50, 0.72) | 0.73 (0.63, 0.82) | 0.67 (0.60, 0.74) | 0.74 (0.67, 0.81) | 0.63 (0.57, 0.69) | 0.71 (0.65, 0.77) | 0.70 (0.66, 0.74) | 0.74 (0.70, 0.78) |
Time to culture negative status in MGIT | 0.59 (0.49, 0.70) | 0.77 (0.69, 0.84) | 0.62 (0.55, 0.69) | 0.74 (0.67, 0.80) | 0.64 (0.57, 0.70) | 0.72 (0.66, 0.78) | 0.67 (0.63, 0.70) | 0.74 (0.70, 0.78) |
Time to smear negative status | 0.62 (0.51, 0.72) | 0.72 (0.64, 0.79) | 0.62 (0.56, 0.69) | 0.73 (0.67, 0.79) | 0.59 (0.53, 0.66) | 0.68 (0.62, 0.74) | 0.66 (0.62, 0.70) | 0.72 (0.68, 0.76) |
Week 6 culture on LJ | 0.55 (0.47, 0.63) | 0.68 (0.60, 0.75) | 0.56 (0.50, 0.62) | 0.70 (0.63, 0.77) | 0.56 (0.51, 0.61) | 0.68 (0.61, 0.74) | 0.63 (0.59, 0.67) | 0.71 (0.67, 0.75) |
Week 8 culture on LJ | 0.51 (0.45, 0.56) | 0.66 (0.57, 0.74) | 0.56 (0.51, 0.61) | 0.71 (0.64, 0.77) | 0.56 (0.52, 0.60) | 0.69 (0.63, 0.75) | 0.63 (0.59, 0.66) | 0.71 (0.66, 0.75) |
Week 12 culture on LJ | 0.55 (0.50, 0.60) | 0.71 (0.63, 0.80) | 0.51 (0.49, 0.53) | 0.69 (0.63, 0.76) | 0.53 (0.50, 0.55) | 0.69 (0.63, 0.75) | 0.62 (0.59, 0.66) | 0.71 (0.67, 0.75) |
Week 6 culture in MGIT | 0.49 (0.41, 0.57) | 0.65 (0.55, 0.74) | 0.51 (0.45, 0.57) | 0.70 (0.63, 0.76) | 0.54 (0.49, 0.60) | 0.65 (0.59, 0.72) | 0.61 (0.57, 0.64) | 0.70 (0.66, 0.74) |
Week 8 culture in MGIT | 0.56 (0.48, 0.64) | 0.70 (0.61, 0.79) | 0.57 (0.51, 0.63) | 0.71 (0.64, 0.78) | 0.61 (0.55, 0.66) | 0.70 (0.64, 0.76) | 0.64 (0.60, 0.68) | 0.72 (0.68, 0.76) |
Week 12 culture in MGIT | 0.58 (0.51, 0.65) | 0.72 (0.64, 0.80) | 0.54 (0.49, 0.58) | 0.71 (0.64, 0.77) | 0.55 (0.51, 0.59) | 0.69 (0.63, 0.75) | 0.63 (0.59, 0.67) | 0.72 (0.68, 0.76) |
Week 6 smear | 0.49 (0.41, 0.57) | 0.65 (0.56, 0.75) | 0.53 (0.47, 0.59) | 0.70 (0.63, 0.76) | 0.57 (0.52, 0.63) | 0.68 (0.62, 0.75) | 0.62 (0.58, 0.66) | 0.71 (0.67, 0.75) |
Week 8 smear | 0.53 (0.46, 0.61) | 0.68 (0.59, 0.77) | 0.55 (0.49, 0.61) | 0.71 (0.64, 0.77) | 0.57 (0.52, 0.62) | 0.69 (0.63, 0.75) | 0.63 (0.59, 0.67) | 0.71 (0.67, 0.75) |
Week 12 smear | 0.54 (0.48, 0.61) | 0.68 (0.60, 0.77) | 0.55 (0.50, 0.60) | 0.70 (0.64, 0.77) | 0.58 (0.53, 0.62) | 0.68 (0.62, 0.74) | 0.63 (0.60, 0.67) | 0.71 (0.67, 0.75) |