Outcome/stratum | Very low HbA1c (<5.0 %) (<31 mmol/mol) | Low HbA1c (5.0 to <5.5 %) (31 to <37 mmol/mol) | Intermediate HbA1c (5.5 to <6.0 %) (37 to <42 mmol/mol) | Increased HbA1c (6.0 to <6.5 %) (42 to <48 mmol/mol) | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ntotal | ncases | IRa | HR (95 % CI)b | ntotal | ncases | IRa | HR | ntotal | ncases | IRa | HR (95 % CI)b | ntotal | ncases | IRa | HR (95 % CI)b | |
All-cause mortality | ||||||||||||||||
50–64 years | 1,688 | 205 | 10.0 | 0.95 (0.81; 1.12) | 6,563 | 769 | 9.8 | Ref | 6,336 | 761 | 10.1 | 0.91 (0.82; 1.01) | 1,514 | 272 | 15.8 | 1.18 (1.02; 1.37) |
≥65 years | 632 | 314 | 53.3 | 1.13 (1.01; 1.27) | 3,779 | 1,556 | 42.6 | Ref | 4,767 | 1,978 | 43.3 | 1.06 (0.99; 1.13) | 1,413 | 723 | 50.4 | 1.14 (1.04; 1.26) |
Cardiovascular mortality | ||||||||||||||||
50–64 years | 1,218 | 61 | 3.7 | 0.99 (0.74; 1.33) | 4,824 | 210 | 3.2 | Ref | 4,915 | 220 | 3.4 | 0.93 (0.76; 1.13) | 1,194 | 78 | 5.3 | 1.14 (0.87; 1.50) |
≥65 years | 548 | 155 | 28.4 | 1.33 (0.86; 2.04)c | 2,574 | 589 | 20.9 | Ref | 3,343 | 753 | 21.2 | 1.07 (0.82; 1.39)c d | 1,035 | 249 | 24.2 | 1.18 (1.01; 1.38) |
Cardiovascular events | ||||||||||||||||
50–64 years | 1,276 | 77 | 5.1 | 0.76 (0.60; 0.97) | 5,626 | 456 | 8.1 | Ref | 5,470 | 507 | 9.6 | 1.09 (0.96; 1.25) | 1,165 | 114 | 10.6 | 1.18 (0.95; 1.47) |
≥65 years | 409 | 82 | 22.4 | 1.15 (0.90; 1.46) | 2,491 | 488 | 22.8 | Ref | 3,207 | 598 | 23.0 | 0.99 (0.88; 1.12) | 846 | 171 | 26.7 | 1.19 (0.98; 1.45) |