Fig. 5

Patterns at progression. Examples of RECIST progression patterns. a ≥20% increase in size of existing disease from nadir defining progression. b New lesions and ≥20% increase in size of existing disease from nadir defining progression. c New lesions only defining progressive disease (R right, L left, green line responding lesion at progression, blue line stable lesion at progression, red line progressing lesion at progression, measurements as per size at baseline)