| Mitochondrial number vs. | BPD (n = 12) | LGCP (n = 15) | LAGB (n = 12) |
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Function | PGC1α | 0.794** | –0.688** | –0.175 |
POLG | 0.867** | –0.407 | 0.035 |
TFAM | 0.479 | –0.560* | –0.154 |
mtND6 | 0.758* | –0.613* | –0.153 |
SDHA | 0.855** | –0.600* | –0.056 |
COX4I1 | 0.939** | –0.442 | 0.147 |
mtATP6 | 0.782** | –0.547* | 0.056 |
UCP2 | 0.818** | –0.389 | 0.063 |
SOD1 | 0.842** | –0.604* | 0.098 |
SOD2 | 0.696* | –0.576* | –0.017 |
Dynamics | MFN2 | 0.983** | –0.493 | 0.939* |
OPA1 | 0.808* | –0.202 | 0.963* |
DRP1 | 0.302 | –0.426 | 0.669 |
FIS1 | 0.871* | –0.337 | 0.209 |
- Table shows Pearson’s correlation coefficient between mitochondrial number and genes involved in mitochondrial biogenesis (PGC1α, POLG, TFAM), oxidative phosphorylation (mtND6, SDHA, COX4I1, mtATP6), uncoupling (UCP2), antioxidant (SOD1, SOD2), fusion (MFN2, OPA1) and fission (DRP1, FIS1) processes. Correlations were calculated using change variables (pre- to 6-months post-surgery percentage change). *P < 0.05, **P < 0.01
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PGC1α Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, POLG mitochondrial DNA polymerase gamma catalytic subunit, TFAM mitochondrial transcription factor A, mtND6 mitochondrially encoded NADH dehydrogenase 6, SDHA Succinate dehydrogenase complex subunit A, COX4I1 Cytochrome c oxidase subunit 4 isoform 1 (complex IV), mtATP6 mitochondria-DNA-encoded ATP synthase subunit 6 (complex V), UCP2 uncoupling protein 2, SOD1 superoxide dismutase 1