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Table 3 Post hoc sensitivity analyses

From: Influence of lack of blinding on the estimation of medication-related harms: a retrospective cohort study of randomized controlled trials

Sensitivity analyses

Lack of blinding on participants

Lack of blinding on health care providers

Lack of blinding on outcome assessors

Funding sources

 Industry funded

0.65 (95% CI: 0.48 to 0.88)

0.65 (95% CI: 0.49 to 0.88)

1.01 (95% CI: 0.94 to 1.08)

Year of publication

 2000 ~ 2010

0.73 (95% CI: 0.57 to 0.93)

0.73 (95% CI: 0.57 to 0.93)

0.90 (95% CI: 0.68 to 1.18)

 2011 ~ 2020

0.38 (95% CI: 0.22 to 0.67)

0.33 (95% CI: 0.23 to 0.48)

1.03 (95% CI: 0.96 to 1.10)

Region

 Europe and North America

0.95 (95% CI: 0.20 to 4.53)

0.75 (95% CI: 0.19 to 2.90)

0.90 (95% CI: 0.72 to 1.13)

 Multiple countries

0.65 (95% CI: 0.47 to 0.90)

0.66 (95% CI: 0.48 to 0.90)

0.95 (95% CI: 0.88 to 1.02)

 Others

0.22 (95% CI: 0.15 to 0.31)

0.22 (95% CI: 0.15 to 0.30)

0.84 (95% CI: 0.49 to 1.44)

Sample size

 Less than 500

0.56 (95% CI: 0.36 to 0.86)

0.50 (95% CI: 0.34 to 0.73)

0.91 (95% CI: 0.80 to 1.03)

 500 or more

0.68 (95% CI: 0.51 to 0.91)

0.68 (95% CI: 0.51 to 0.91)

1.05 (95% CI: 0.95 to 1.16)