Table 1 Significant associations of HNSCC PRS with PheWAS in the UK Biobank that were also replicated in the Penn Medicine Biobank
Phenotype description | UK Biobanka | Penn Medicine Biobankb (replication cohort) | |||
|---|---|---|---|---|---|
No. of cases (prevalence, %) | OR per SD increase (95% CI) | P-value | OR per SD increase (95% CI) | P-value | |
HNSCC PRS | |||||
 Tobacco use disorder | 20,599 (6.7%) | 1.06 (1.05–1.08) | 3.50 × 10−15 | 1.04 (1.02–1.07) | 1.05 × 10−3 |
 Alcoholism | 9636 (3.1%) | 1.06 (1.04–1.09) | 6.14 × 10−9 | 1.11 (1.01–1.22) | 2.29 × 10−2 |
 Alcohol-related disorders | 6015 (1.9%) | 1.08 (1.05–1.11) | 1.09 × 10−8 | 1.11 (1.02–1.22) | 2.22 × 10−2 |
 Emphysema | 2096 (0.7%) | 1.11 (1.06–1.16) | 5.48 × 10−6 | 1.10 (1.03–1.16) | 2.44 × 10−3 |
 Chronic airway obstruction | 9151 (3.0%) | 1.05 (1.03–1.07) | 2.64 × 10−5 | 1.08 (1.04–1.11) | 2.16 × 10−5 |
 Cancer of bronchus; lung | 2781 (0.9%) | 1.08 (1.04–1.13) | 4.68 × 10−5 | 1.12 (1.05–1.19) | 4.44 × 10−4 |
OPC PRS | |||||
 Tobacco use disorder | 20,599 (6.7%) | 1.06 (1.04–1.07) | 2.85 × 10−13 | 1.04 (1.02–1.07) | 1.43 × 10−3 |
 Cancer of bronchus; lung | 2781 (0.9%) | 1.09 (1.05–1.13) | 1.27 × 10−5 | 1.07 (1.01–1.14) | 2.05 × 10−2 |
 Chronic airway obstruction | 9151 (3.0%) | 1.05 (1.02–1.07) | 4.32 × 10−5 | 1.04 (1.01–1.08) | 1.20 × 10−2 |
OC PRS | |||||
 Tobacco use disorder | 20,599 (6.7%) | 1.04 (1.02–1.05) | 3.20 × 10−7 | 1.04 (1.02–1.07) | 1.48 × 10−3 |