Table 2 Sensitivity analysis results of HNSCC PRS with significant associations in the UK Biobank

HNCSS PRS

 Tobacco use disorder

1.06 (1.04–1.07)

6.83 × 10⁻¹⁴

1.06 (1.05–1.08)

3.41 × 10⁻¹⁵

1.06 (1.04–1.07)

6.84 × 10⁻¹⁴

 Alcoholism

1.06 (1.04–1.08)

5.38 × 10⁻⁸

1.06 (1.04–1.09)

6.09 × 10⁻⁹

1.06 (1.04–1.08)

5.28 × 10⁻⁸

 Alcohol-related disorders

1.08 (1.05–1.11)

6.98 × 10⁻⁸

1.08 (1.05–1.11)

1.04 × 10⁻⁸

1.08 (1.05–1.11)

6.57 × 10⁻⁸

 Emphysema

1.11 (1.06–1.16)

9.15 × 10⁻⁶

1.11 (1.06–1.16)

4.92 × 10⁻⁶

1.11 (1.06–1.16)

8.41 × 10⁻⁶

 Chronic airway obstruction

1.04 (1.02–1.07)

1.20 × 10⁻⁴

1.05 (1.02–1.07)

2.70 × 10⁻⁵

1.04 (1.02–1.07)

1.12 × 10⁻⁴

 Cancer of bronchus; lung

1.08 (1.04–1.13)

6.41 × 10⁻⁵

1.08 (1.04–1.13)

5.01 × 10⁻⁵

1.08 (1.04–1.13)

6.90 × 10⁻⁵

OPC PRS

 Tobacco use disorder

1.05 (1.04–1.07)

5.51 × 10⁻¹²

1.05 (1.04–1.07)

2.72 × 10⁻¹²

1.05 (1.04–1.07)

2.44 × 10⁻¹¹

 Cancer of bronchus; lung

1.09 (1.05–1.13)

2.30 × 10⁻⁵

1.09 (1.05–1.13)

1.62 × 10⁻⁵

1.09 (1.05–1.13)

2.49 × 10⁻⁵

 Chronic airway obstruction

1.04 (1.02–1.07)

1.62 × 10⁻⁴

1.04 (1.02–1.07)

1.06 × 10⁻⁴

1.04 (1.02–1.06)

2.99 × 10⁻⁴

OC PRS

 Tobacco use disorder

1.04 (1.02–1.05)

1.36 × 10⁻⁶

1.04 (1.02–1.05)

2.42 × 10⁻⁷

1.04 (1.02–1.05)

9.64 × 10⁻⁷