Table 3 Sex-stratified results of HNSCC PRS with significant associations in the UK Biobank
Phenotype description |  | Male (n = 140,232) | Female (n = 168,260) | Sex-interaction | ||
|---|---|---|---|---|---|---|
No. of cases (%) | OR per SD increase (95% CI) | P-value | OR per SD increase (95% CI) | P-value | P-value for interaction | |
HNSCC PRS | ||||||
 Tobacco use disorder | 20,599 (6.7%) | 1.06 (1.04–1.08) | 3.06 × 10−8 | 1.07 (1.04–1.09) | 1.26 × 10−8 | .207 |
 Alcoholism | 9636 (3.1%) | 1.06 (1.03–1.09) | 1.44 × 10−5 | 1.07 (1.03–1.11) | 9.08 × 10−5 | .886 |
 Alcohol-related disorders | 6015 (1.9%) | 1.08 (1.05–1.12) | 5.95 × 10−7 | 1.07 (1.02–1.13) | 4.35 × 10−3 | .830 |
 Emphysema | 2096 (0.7%) | 1.10 (1.04–1.16) | 1.50 × 10−3 | 1.13 (1.05–1.21) | 9.79 × 10−4 | .470 |
 Chronic airway obstruction | 9151 (3.0%) | 1.04 (1.02–1.08) | 2.95 × 10−3 | 1.05 (1.02–1.09) | 2.94 × 10−3 | .591 |
 Cancer of bronchus; lung | 2781 (0.9%) | 1.10 (1.05–1.16) | 2.74 × 10−4 | 1.06 (1.00–1.12) | 4.04 × 10−2 | .365 |