Table 1 Baseline demographic and clinical characteristics by geographic region

N

3889

2396

813

285

177

110

108

Demographics

 Age (years)

59.0 ± 13.3

59.5 ± 13.7

56.2 ± 12.4

61.2 ± 11.4

61.8 ± 13.2

58.8 ± 9.7

59.8 ± 14.6

 < .0001

 Male

2981 (76.7)

1771 (73.9)

652 (80.2)

240 (84.2)

134 (75.7)

89 (80.9)

95 (88.0)

 < .0001

Indication for ICD/CRT-D

 PP

2696 (69.3)

1556 (64.9)

642 (79.0)

221 (77.5)

127 (71.8)

80 (72.7)

70 (64.8)

 < .0001

 ICD/CRT-D implant

2465 (63.4)

1662 (69.4)

292 (35.9)

147 (51.6)

163 (92.1)

109 (99.1)

94 (87.0)

 < .0001

 CRT-D implanted

811 (20.9)

535 (22.3)

89 (10.9)

24 (8.4)

64 (36.2)

58 (52.7)

41 (38.0)

 < .0001

Medical history

 NYHA Class, I/II/III/IV (%)

5.1/43.4/

42.8/1.1

5/30.3/53.4/1.5

4.2/68.5/23.2/0.5

6/76.8/11.6/0

10.7/52.5/31.6/0.6

2.7/33.6/61.8/0

6.5/50/38/1.9

 < .0001

 Coronary artery disease

1660 (42.7)

818 (34.1)

463 (57.0)

202 (70.9)

73 (41.2)

58 (52.7)

46 (42.6)

 < .0001

 ICM

838 (21.5)

392 (16.4)

223 (27.4)

67 (23.5)

84 (47.5)

31 (28.2)

41 (38.0)

 < .0001

 NICM

2238 (57.5)

1518 (63.4)

382 (47.0)

150 (52.6)

82 (46.3)

49 (44.5)

57 (52.8)

 < .0001

 Dilated cardiomyopathy

2119 (54.5)

1414 (59.0)

363 (44.6)

147 (51.6)

87 (49.2)

47 (42.7)

61 (56.5)

 < .0001

 Hypertrophic Cardiomyopathy

92 (2.4)

78 (3.3)

8 (1.0)

1 (0.4)

3 (1.7)

1 (0.9)

1 (0.9)

0.0005

 Valvular disfunction

1070 (27.5)

804 (33.6)

94 (11.6)

44 (15.4)

63 (35.6)

52 (47.3)

13 (12.0)

 < .0001

 Primary/idiopathic electrical disease

160 (4.1)

118 (4.9)

12 (1.5)

7 (2.5)

19 (10.7)

1 (0.9)

3 (2.8)

 < .0001

 Idiopathic structural heart disease

55 (1.4)

20 (0.8)

11 (1.4)

0 (0.0)

15 (8.5)

3 (2.7)

5 (5.6)

 < .0001

 Congestive heart failure

1323 (34)

929 (38.8)

121 (14.9)

139 (48.8)

45 (25.4)

60 (54.5)

29 (26.9)

 < .0001

 Syncope or presyncope

672 (17.3)

426 (17.8)

117 (14.4)

25 (8.8)

38 (21.5)

23 (20.9)

43 (39.8)

 < .0001

 NSVT

986 (25.4)

745 (31.1)

92 (11.3)

39 (13.7)

42 (23.7)

38 (34.5)

30 (27.8)

 < .0001

 Hypertension

1436 (36.9)

843 (35.2)

251 (30.9)

191 (67.0)

60 (33.9)

61 (55.5)

30 (27.8)

 < .0001

 Diabetes

1066 (27.7)

518 (21.7)

317 (40.7)

133 (46.8)

40 (22.6)

17 (15.5)

41 (38.0)

 < .0001

 Myocardial infarction

1260 (32.4)

544 (22.7)

423 (52.0)

123 (43.2)

81 (45.8)

48 (43.6)

41 (38.0)

 < .0001

 LBBB

735 (18.9)

410 (17.1)

169 (20.8)

21 (7.4)

45 (25.4)

48 (43.6)

42 (38.9)

 < .0001

 PR duration (ms)

175 ± 41.1

178 ± 41.3

164.8 ± 37.9

179.9 ± 36.9

169.1 ± 46.5

188.4 ± 37.2

170.4 ± 48.7

 < .0001

 QRS duration (ms)

121.7 + 34.3

122.7 ± 34.3

119.3 ± 35.2

108.3 ± 23.5

125.3 ± 37.1

139.0 ± 37.7

128.6 ± 33.6

 < .0001

 LVEF (%)

31.6 ± 12.5

33.7 ± 13.6

28.2 ± 7.8

25.8 ± 9.5

28.7 ± 11.1

33.7 ± 13.0

29.1 ± 11.1

 < .0001

Baseline therapy

 Antiarrhythmics, excluding beta blockers

1660 (42.7)

1162 (48.5)

261 (32.1)

56 (19.6)

95 (53.7)

43 (39.1)

43 (39.8)

 < .0001

 Beta blockers

2772 (71.35)

1645 (68.7)

623 (76.6)

207 (72.6)

124 (70.1)

85 (77.3)

88 (81.5)

 < .0001

 ACEI/ARB

2467 (63.4)

1500 (62.6)

491 (60.4)

172 (60.4)

126 (71.2)

92 (83.6)

86 (79.6)

 < .0001

 Diuretics

2793 (71.8)

1702 (71.0)

607 (74.7)

178 (62.5)

124 (70.1)

92 (83.6)

90 (83.3)

 < .0001

Outcomes

 All-cause mortality (PP)

321 (11.9)

171 (11.0)

69 (10.7)

48 (21.7)

17 (13.4)

4 (5.0)

12 (17.1)

 < .0001

 All-cause mortality (SP)

112 (9.4)

58 (6.9)

22 (12.9)

8 (12.5)

11 (22.0)

2 (6.7)

11 (28.9)

 < .0001

 SCD (PP)

88 (3.3)

28 (1.8)

46 (7.2)

10 (4.5)

1 (0.8)

2 (2.5)

1 (1.4)

 < .0001

 SCD (SP)

29 (2.4)

8 (1.0)

15 (8.8)

0 (0.0)

3 (6.0)

1 (3.3)

2 (5.3)

 < .0001