Table 2 Univariate and multivariate analysis of variables associated with all-cause mortality in PP patients and SP patients with ICDs/CRT-Ds

Demographics

 Age (years)

1.023 (1.013, 1.032)

 < .0001

1.025 (1.015, 1.035)

 < .0001

1.046 (1.031, 1.062)

 < .0001

1.031 (1.014, 1.048)

0.0004

 Gender male

0.886 (0.690, 1.139)

0.3455

0.897 (0.691, 1.163)

0.4107

1.708 (1.019, 2.863)

0.0421

1.497 (0.855, 2.621)

0.1583

Medical History

 NYHA III-IV

1.664 (1.326, 2.089)

 < .0001

1.726 (1.322, 2.253)

 < .0001

2.801 (1.930, 4.066)

 < .0001

1.410 (0.918, 2.166)

0.1168

 ICM

1.200 (0.931, 1.548)

0.1588

1.219 (0.928, 1.602)

0.1556

2.156 (1.468, 3.167)

 < .0001

1.052 (0.679, 1.631)

0.8199

 NICM

0.834 (0.664, 1.048)

0.1197

1.058 (0.714, 1.570)

0.7777

 Congestive heart failure

1.695 (1.361, 2.110)

 < .0001

1.569 (1.246, 1.977)

0.0001

3.436 (2.357, 5.009)

 < .0001

2.227 (1.466, 3.382)

0.0002

 Syncope

0.881 (0.554, 1.401)

0.5923

1.153 (0.795, 1.671)

0.4536

 NSVT

1.313 (1.041, 1.656)

0.0214

0.815 (0.473, 1.404)

0.4614

 Hypertension

1.047 (0.837, 1.309)

0.6878

1.563 (1.076, 2.270)

0.0191

 Diabetes

1.283 (1.017, 1.618)

0.0358

1.280 (1.007, 1.626)

0.0435

1.951 (1.311, 2.903)

0.001

 Myocardial infarction

1.258 (1.006, 1.572)

0.044

2.272 (1.562, 3.303)

 < .0001

1.672 (1.083, 2.582)

0.0203

 Left Buddle Branch Block

0.792 (0.605, 1.036)

0.0891

1.413 (0.738, 2.707)

0.297

 PR interval

1.003 (1.001, 1.006)

0.0086

1.003 (0.999, 1.007)

0.1413

 QRS duration

1.001 (0.997, 1.004)

0.7099

1.007 (1.003, 1.011)

0.0016

 LVEF

0.950 (0.933, 0.968)

 < .0001

0.951 (0.934, 0.970)

 < .0001

0.954 (0.941, 0.968)

 < .0001

0.978 (0.961, 0.995)

0.0127

Therapy

 Antiarrhythmics excluding beta blockers

1.502 (1.206, 1.870)

0.0003

1.287 (1.016, 1.630)

0.0366

1.777 (1.210, 2.611)

0.0034

 Beta blockers

0.768 (0.604, 0.977)

0.0319

1.050 (0.717, 1.538)

0.7014

 ACEI/ARB

0.662 (0.527, 0.832)

0.0004

0.711 (0.561, 0.901)

0.0048

1.066 (0.736, 1.546)

0.7343

0.555 (0.375, 0.822)

0.0033

 Diuretics

1.613 (1.136, 2.292)

0.0076

3.612 (2.396, 5.445)

 < 0.0001

2.132 (1.343, 3.384)

0.0013

 ICD implanted

0.840 (0.647, 1.090)

0.1901

0.652 (0.495, 0.860)

0.0024

-

-

 CRT-D implanted

0.627 (0.473, 0.832)

0.0012

0.417 (0.308, 0.564)

 < .0001

1.669 (1.029, 2.707)

0.038

Region

 Southeast Asia

1 (ref)

1 (ref)

1 (ref)

1 (ref)

 East Asia

0.973 (0.779, 1.216)

0.8111

0.561 (0.416, 0.756)

0.0002

0.515 (0.355, 0.748)

0.0005

 South Asia

0.709 (0.541, 0.930)

0.0129

1.341 (0.840, 2.140)

0.2183

 Latin America

1.106 (0.678, 1.805)

0.6856

2.093 (1.122, 3.903)

0.0202

2.014 (1.047, 3.874)

0.036

 Europe

0.509 (0.190, 1.365)

0.1795

0.680 (0.168, 2.750)

0.5881

 Middle East and Africa

1.439 (0.808, 2.562)

0.2164

3.769 (2.022, 7.027)

 < 0.0001

3.684 (1.876, 7.237)

0.0002