Fig. 5From: TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitroR788 and AMX suppressed cGAS/STING-dependent pro-inflammatory signaling induced by TDP-43/SOD1. A Western blotting analyzed the levels of transiently transfected ALS toxic proteins and p-TBK1 in NSC-34 cells. B WB analysis of p-TBK1, p-p65, and p-IRF3 in doxycycline-inducible TDP43/Q331K NSC-34 cells. C–H RT-qPCR showed the relative levels (normalized with GAPDH) of IFNB, TNFA, and IL6 from NSC-34 cells treated with R788 (10 μM) or AMX (200 μM)Back to article page