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Table 1 Characteristic of the participants

From: Gut microbiome features and metabolites in non-alcoholic fatty liver disease among community-dwelling middle-aged and older adults

 

Discovery cohort

Internal validation cohort

Prospective validation cohort

No. of participants

1546

377

749

Non-alcoholic fatty liver disease case subjects, n (%)

867 (56.1)

126 (33.4)

266 (35.5)

Age (years)

64.9 (5.9)

65.0 (5.1)

64.6 (6.1)

Sex, n (%)

 Female

1057(68.4)

277 (73.5)

523 (69.8)

 Male

489 (31.6)

100 (26.5)

226 (30.2)

Marital status, n (%)

 Married

1326 (85.8)

335 (88.9)

640 (85.4)

 others

216 (14.0)

42 (11.1)

109 (14.6)

Education, n (%)

 Middle school or less

419 (27.1)

87 (23.1)

208 (27.8)

 High school or professional college

706 (45.7)

175 (46.4)

339 (45.2)

 University

408 (26.4)

115 (30.5)

202 (27.0)

Income (yuan/month/person), n (%)

 ≤ 500

323 (20.9)

83 (22.0)

9 (1.2)

 501–1500

751 (48.6)

220 (56.4)

144 (19.2)

 1501–3000

69 (4.5)

8 (2.1)

337 (45.0)

 > 3000

368 (23.8)

62 (16.4)

259 (34.6)

BMI, kg/m2

23.5 ± 3.1

23.1 ± 3.0

22.3 ± 2.6

Waist circumference, cm

84.8 ± 8.9

83.9 ± 8.7

81.5 ± 8.3

Hip circumference, cm

91.5 ± 12.1

90.6 ± 7.7

89.9 ± 15.5

Fasting glucose, mmol/L

5.5 ± 1.3

5.5 ± 1.2

5.3 ± 1.2

TC, mmol/L

5.5 ± 1.1

5.6 ± 1.1

5.6 ± 1.1

LDL, mmol/L

3.6 ± 1.0

3.6 ± 1.0

3.7 ± 1.0

TG, mmol/L

1.6 ± 1.1

1.6 ± 1.3

1.4 ± 0.9

HDL, mmol/L

1.6 ± 1.1

1.6 ± 1.3

1.4 ± 0.9

Current smoking status, n (%)

110 (7.1)

17 (4.5)

51 (6.8)

Current tea drinking, n (%)

833 (53.9)

198 (52.5)

388 (51.8)

Current alcohol drinking, n (%)

110 (7.1)

17 (4.5)

51 (6.8)

Physical activity, MET

18.9 (6.9)

19.3 (7.0)

19.6 (7.0)

Total energy intake, kcal/day

1719.3 ± 581.2

1761.7 ± 503.1

1715.9 ± 581.2

Vegetable intake, g/day

332.5 ± 166.7

327.1 ± 160.4

334.1 ± 164.8

Fish intake, g/day

41.4 ± 42.2

44.3 ± 57.5

43.2 ± 51.9

Red and processed meat intake, g/day

80.3 ± 52.7

79.6 ± 43.6

82.9 ± 61.1

Fruit intake, g/day

152.7 ± 105.1

150.0 ± 107.7

151.3 ± 101.0

Yogurt intake, g/day (dry weight)

30.5 ± 46.2

29.2 ± 42.8

29.9 ± 43.4

  1. Continuous variables are presented as means ± standard deviation (SD) unless otherwise indicate; categorical variables are presented as number (percentage)
  2. Abbreviations: BMI, body mass index; HDL, high density lipoprotein; LDL, low density lipoprotein; MET, metabolic equivalent; TC, total cholesterol; TG, triglycerides