Outcome | CQI, HR (95% CI) | Continuous (per SD increment) | ||||
---|---|---|---|---|---|---|
Quartile 1 (lowest) | Quartile 2 | Quartile 3 | Quartile 4 (highest) | P for trenda | ||
Mean (SD) value of CQI | 8.4 (1.6) | 11.5 (0.5) | 13.5 (0.5) | 16.1 (1.2) | ||
Person-years | 488,250 | 354,591 | 342,265 | 347,391 | ||
Overallb | ||||||
Cases, n | 123 | 66 | 68 | 54 | ||
Incidence rate (95% CI)c | 0.25 (0.21, 0.30) | 0.19 (0.15, 0.24) | 0.20 (0.16, 0.25) | 0.16 (0.12, 0.20) | ||
Model 1d | 1.00 (reference) | 0.68 (0.50, 0.92) | 0.70 (0.52, 0.94) | 0.52 (0.38, 0.72) | < 0.001 | 0.79 (0.70, 0.88) |
Model 2e | 1.00 (reference) | 0.74 (0.55, 1.00) | 0.79 (0.58, 1.07) | 0.62 (0.44, 0.87) | 0.004 | 0.84 (0.75, 0.95) |
Model 3f | 1.00 (reference) | 0.74 (0.54, 1.00) | 0.79 (0.58, 1.07) | 0.61 (0.44, 0.86) | 0.004 | 0.84 (0.75, 0.95) |
Proximal colon | ||||||
Cases, n | 61 | 45 | 41 | 34 | ||
Incidence rate (95% CI)c | 0.12 (0.10, 0.16) | 0.13 (0.09, 0.17) | 0.12 (0.09, 0.16) | 0.10 (0.07, 0.14) | ||
Model 1d | 1.00 (reference) | 0.93 (0.63, 1.38) | 0.85 (0.57, 1.26) | 0.66 (0.43, 1.01) | 0.054 | 0.85 (0.73, 0.99) |
Model 2e | 1.00 (reference) | 1.02 (0.69, 1.50) | 0.97 (0.64, 1.46) | 0.79 (0.51, 1.24) | 0.344 | 0.92 (0.78, 1.08) |
Model 3f | 1.00 (reference) | 1.01 (0.68, 1.49) | 0.96 (0.64, 1.44) | 0.78 (0.50, 1.22) | 0.300 | 0.91 (0.78, 1.07) |
Distal colon | ||||||
Cases, n | 33 | 12 | 11 | 15 | ||
Incidence rate (95% CI)c | 0.07 (0.05, 0.09) | 0.03 (0.02, 0.06) | 0.04 (0.02, 0.06) | 0.04 (0.03, 0.07) | ||
Model 1d | 1.00 (reference) | 0.42 (0.21, 0.83) | 0.45 (0.23, 0.87) | 0.53 (0.28, 0.98) | 0.019 | 0.76 (0.60, 0.96) |
Model 2e | 1.00 (reference) | 0.45 (0.23, 0.91) | 0.51 (0.26, 1.01) | 0.64 (0.33, 1.22) | 0.092 | 0.82 (0.64, 1.06) |
Model 3f | 1.00 (reference) | 0.45 (0.23, 0.91) | 0.52 (0.26, 1.02) | 0.64 (0.33, 1.24) | 0.099 | 0.82 (0.64, 1.06) |
Rectum | ||||||
Cases, n | 28 | 9 | 12 | 5 | ||
Incidence rate (95% CI)c | 0.06 (0.04, 0.08) | 0.03 (0.01, 0.05) | 0.04 (0.02, 0.06) | 0.01 (0.01, 0.03) | ||
Model 1d | 1.00 (reference) | 0.43 (0.20, 0.91) | 0.58 (0.29, 1.15) | 0.23 (0.09, 0.61) | 0.001 | 0.64 (0.49, 0.85) |
Model 2e | 1.00 (reference) | 0.47 (0.22, 1.01) | 0.66 (0.32, 1.33) | 0.27 (0.10, 0.73) | 0.006 | 0.69 (0.52, 0.93) |
Model 3f | 1.00 (reference) | 0.47 (0.22, 1.01) | 0.66 (0.32, 1.34) | 0.27 (0.10, 0.73) | 0.006 | 0.69 (0.52, 0.93) |