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Table 2 Hazard ratios (HRs) and 95% confidence intervals (CIs) for hematological parameters trajectories associated with incident severity of COVID-19

From: Characterization and trajectories of hematological parameters prior to severe COVID-19 based on a large-scale prospective health checkup cohort in western China: a longitudinal study of 13-year follow-up

Hematological parameters

Trajectories

Unadjusted model

Model 1

Model 2

Model 3

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

Red blood cell count

Decreasing (ref.)

        

Increasing

0.651 [0.318, 1.331]

0.239

1.075 [0.507, 2.278]

0.85

1.039 [0.479, 2.250]

0.923

1.055 [0.488, 2.279]

0.891

Red cell distribution width (SD)

Low-increasing (ref.)

        

High-increasing

3.654 [1.406, 9.497]

0.008

1.063 [0.357, 3.169]

0.913

1.043 [0.349, 3.118]

0.941

0.962 [0.308, 3.009]

0.947

Red cell distribution width (CV)

Stable (ref.)

        

Decreasing

0.000 [0.000, Inf]

0.997

0.000 [0.000, Inf]

0.997

0.000 [0.000, Inf]

0.997

0.000 [0.000, Inf]

0.997

Mean corpuscular hemoglobin

N-shape (ref.)

        

Increasing

0.601 [0.144, 2.514]

0.486

0.436 [0.102, 1.867]

0.263

0.421 [0.098, 1.810]

0.245

0.406 [0.091, 1.811]

0.237

Mean corpuscular volume

N-shape (ref.)

        

Increasing

0.732 [0.175, 3.059]

0.669

0.651 [0.154, 2.760]

0.561

0.638 [0.150, 2.711]

0.543

0.685 [0.157, 2.983]

0.614

White blood cell count

U-shape (ref.)

        

Decreasing

1.738 [0.861, 3.508]

0.123

0.795 [0.361, 1.752]

0.569

0.744 [0.327, 1.693]

0.482

0.728 [0.315, 1.679]

0.456

Neutrophil count

Inverted N shape (ref.)

        

N-shape

0.261 [0.080, 0.854]

0.026

0.481 [0.144, 1.611]

0.236

0.486 [0.144, 1.644]

0.246

0.499 [0.146, 1.699]

0.266

Lymphocytes count

stable (ref.)

        

Low-decreasing

0.787 [0.369, 1.677]

0.534

0.969 [0.431, 2.182]

0.94

0.981 [0.433, 2.222]

0.963

0.922 [0.392, 2.169]

0.853

U-shape

4.287 [1.275, 14.413]

0.019

3.584 [1.039, 12.363]

0.043

3.778 [1.054, 13.544]

0.041

3.823 [1.027, 14.231]

0.045

Lymphocyte percentage

Decreasing (ref.)

        

U-shape

2.406 [0.733, 7.891]

0.148

2.662 [0.794, 8.919]

0.113

2.654 [0.784, 8.984]

0.117

2.757 [0.790, 9.621]

0.112

Basophil count

Stable (ref.)

        

Increasing

0.364 [0.087, 1.519]

0.166

0.628 [0.145, 2.722]

0.535

0.536 [0.117, 2.457]

0.422

0.558 [0.122, 2.557]

0.453

Basophil percentage

Stable (ref.)

        

Inverted U-shape

0.517 [0.071, 3.783]

0.516

1.058 [0.141, 7.935]

0.956

0.957 [0.123, 7.449]

0.967

1.074 [0.134, 8.584]

0.946

Eosinophil percentage

N-shape (ref.)

        

Stable

0.711 [0.170, 2.968]

0.64

0.391 [0.091, 1.688]

0.209

0.380 [0.087, 1.651]

0.197

0.338 [0.075, 1.517]

0.157

Monocyte count

J-shape (ref.)

        

Inverted U-shape

0.464 [0.109, 1.965]

0.297

0.931 [0.201, 4.317]

0.928

0.866 [0.185, 4.046]

0.855

0.736 [0.148, 3.659]

0.708

Monocyte percentage

J-shape (ref.)

        

Inverted U-shape

0.683 [0.209, 2.237]

0.529

0.959 [0.277, 3.325]

0.948

0.983 [0.272, 3.559]

0.979

1.069 [0.292, 3.913]

0.92

Blood platelet count

U-shape (ref.)

        

Inverted U-shape

0.492 [0.172, 1.404]

0.185

1.612 [0.521, 4.986]

0.407

1.608 [0.518, 4.997]

0.411

1.678 [0.532, 5.300]

0.377

Monocyte-to-lymphocyte ratio

U-shape (ref.)

        

Increasing

0.694 [0.208, 2.314]

0.552

0.407 [0.115, 1.439]

0.163

0.376 [0.103, 1.374]

0.139

0.388 [0.108, 1.398]

0.148

Neutrophil-to-lymphocyte ratio

N-shape (ref.)

        

Stable

0.336 [0.102, 1.102]

0.072

0.533 [0.125, 2.276]

0.396

0.541 [0.126, 2.326]

0.409

0.530 [0.120, 2.350]

0.404

Eosinophil-to-lymphocyte ratio

Stable (ref.)

        

Increasing

1.808 [0.523, 6.258]

0.350

1.536 [0.416, 5.673]

0.520

1.646 [0.440, 6.162]

0.459

1.574 [0.417, 5.936]

0.503

Platelet-to-lymphocyte ratio

N-shape (ref.)

        

Stable

0.878 [0.305, 2.530]

0.809

0.429 [0.145, 1.271]

0.127

0.420 [0.139, 1.271]

0.125

0.436 [0.140, 1.356]

0.151

U-shape

1.335 [0.376, 4.737]

0.654

0.570 [0.158, 2.059]

0.391

0.541 [0.147, 1.995]

0.356

0.530 [0.142, 1.971]

0.343

  1. Ref. The reference group in the model; Model 1: adjusted for baseline age, gender, and BMI; Model 2: further adjusted for smoking status and drinking habits; Model 3: further adjusted for hypertension and diabetes
  2. Red cell distribution width (SD), red blood cell distribution width standard deviation; Red cell distribution width (CV), red blood cell distribution width coefficient of variation
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BMC Medicine

ISSN: 1741-7015

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