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Fig. 3 | BMC Medicine

Fig. 3

From: Autotaxin inhibition attenuates the aortic valve calcification by suppressing inflammation-driven fibro-calcific remodeling of valvular interstitial cells

Fig. 3

Effects of ATX inhibition on the production of cytokines related to the infiltration of immune cells, proinflammatory/anti-inflammatory responses, and fibrosis and osteogenesis in human VICs from FCAVD patients. A–F The human VICs were cultured in an osteogenic medium for 3 weeks in the presence or absence of BBT-877 (1 μM), and the indicated cytokines were measured by ELISA. A Chemokines. B Growth factors for immune cells. C Proinflammatory cytokines. D Anti-inflammatory cytokines. E Cytokines related to osteogenesis. F Cytokines related to fibrosis. Data are presented as the mean ± SD of triplicate ELISA tests. A representative set of results from more than three independent experiments is presented. *P < 0.05, **P < 0.01, ***P < 0.001 versus vehicle control. P values were obtained using a two-tailed t-test

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BMC Medicine

ISSN: 1741-7015

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