Fig. 4

Association Between Sodium Intake and Risk of Cardiovascular Disease Using a Cubic-Restricted Spline Model in the Dose–Response Meta-Analysis Based on 29 Published Studies. The solid line represents the relative risk of cardiovascular disease according to sodium intake, and the dashed lines denote the 95% confidence intervals (P_nonlinearity < 0.001). The spline was computed on the basis of three knots selected at 5^th, 50^th, 95^th percentiles of sodium intake, and the red line depicts the sodium intake of 2,300 mg/day. The analysis included 2,056,043 participants from 29 cohort studies with 66,526 CVD events