Association between inflammatory bowel disease and cancer risk: evidence triangulation from genetic correlation, Mendelian randomization, and colocalization analyses across East Asian and European populations

Table 1 The genetic correlations between IBD and cancers caused by LDSC in the East Asian population

Outcomes	IBD			CD			UC
Outcomes	r_g	se	P	r_g	se	P	r_g	se	P
Colorectal cancer	− 0.082	0.080	0.305	− 0.151	0.078	0.052	− 0.022	0.099	0.820
Esophageal cancer	− 0.040	0.069	0.565	− 0.099	0.071	0.161	− 0.013	0.084	0.879
Stomach cancer	0.073	0.075	0.334	0.069	0.073	0.340	0.025	0.089	0.778
Liver cell cancer	NA	NA	NA	NA	NA	NA	NA	NA	NA
Cervical cancer	− 0.140	0.112	0.214	− 0.202	0.122	0.096	− 0.069	0.126	0.586
Prostate cancer	− 0.062	0.072	0.388	− 0.084	0.078	0.283	− 0.022	0.087	0.804
Lung cancer	− 0.009	0.120	0.941	− 0.051	0.125	0.683	− 0.025	0.146	0.864
Breast cancer	− 0.049	0.066	0.452	− 0.088	0.068	0.194	− 0.022	0.078	0.776

CD Crohn’s disease, IBD inflammatory bowel disease, LDSC linkage disequilibrium score regression, NA not available, UC ulcerative colitis

ISSN: 1741-7015