Table 2 The genetic correlations between IBD and cancers caused by LDSC in the European population
Outcomes | IBD | CD | UC | ||||||
|---|---|---|---|---|---|---|---|---|---|
rg | se | P | rg | se | P | rg | se | P | |
Oropharynx cancer | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Esophageal cancer | 0.057 | 0.036 | 0.110 | 0.042 | 0.034 | 0.217 | 0.054 | 0.043 | 0.214 |
Stomach cancer | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Small bowel cancer |  − 0.066 | 0.138 | 0.636 |  − 0.092 | 0.166 | 0.579 | 0.022 | 0.119 | 0.855 |
Colorectal cancer |  − 0.032 | 0.045 | 0.476 |  − 0.017 | 0.043 | 0.685 |  − 0.030 | 0.053 | 0.566 |
Anus cancer | 0.011 | 0.035 | 0.748 | 0.043 | 0.037 | 0.244 |  − 0.003 | 0.043 | 0.954 |
Liver cancer | 0.035 | 0.100 | 0.727 |  − 0.008 | 0.089 | 0.925 | 0.133 | 0.316 | 0.673 |
Bile duct cancer | 0.011 | 0.052 | 0.830 | 0.042 | 0.063 | 0.510 | 0.026 | 0.069 | 0.702 |
Liver cell cancer |  − 0.026 | 0.031 | 0.397 |  − 0.031 | 0.030 | 0.310 |  − 0.029 | 0.038 | 0.452 |
Pancreatic cancer | 0.038 | 0.045 | 0.395 | 0.002 | 0.044 | 0.974 | 0.052 | 0.050 | 0.299 |
Hodgkin lymphoma | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Non-Hodgkin lymphoma |  − 0.026 | 0.033 | 0.417 |  − 0.017 | 0.033 | 0.612 |  − 0.044 | 0.038 | 0.250 |
Leukemia |  − 0.056 | 0.046 | 0.225 |  − 0.040 | 0.043 | 0.353 |  − 0.020 | 0.053 | 0.714 |
Multiple myeloma | 0.004 | 0.030 | 0.898 |  − 0.024 | 0.030 | 0.434 | 0.037 | 0.039 | 0.338 |
Skin melanoma cancer | 0.002 | 0.020 | 0.939 | 0.006 | 0.019 | 0.772 | 0.003 | 0.026 | 0.909 |
Nonmelanoma skin cancer |  − 0.001 | 0.012 | 0.935 | 0.006 | 0.013 | 0.657 |  − 0.004 | 0.016 | 0.790 |
Squamous cell cancer | 0.005 | 0.009 | 0.527 | 0.0004 | 0.009 | 0.961 | 0.014 | 0.011 | 0.204 |
Kidney cancer | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Bladder cancer | 0.060 | 0.036 | 0.092 | 0.047 | 0.035 | 0.175 | 0.055 | 0.040 | 0.163 |
Prostate cancer |  − 0.024 | 0.016 | 0.135 |  − 0.012 | 0.015 | 0.429 |  − 0.030 | 0.019 | 0.126 |
Cervical cancer | 0.002 | 0.029 | 0.944 |  − 0.005 | 0.028 | 0.846 | 0.015 | 0.032 | 0.645 |
Corpus uteri cancer |  − 0.064 | 0.062 | 0.306 |  − 0.038 | 0.056 | 0.504 |  − 0.088 | 0.080 | 0.270 |
Ovarian cancer | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Lung cancer |  − 0.006 | 0.015 | 0.676 |  − 0.002 | 0.014 | 0.877 |  − 0.001 | 0.019 | 0.966 |
Breast cancer | 0.003 | 0.016 | 0.825 |  − 0.006 | 0.016 | 0.698 | 0.010 | 0.018 | 0.586 |
Thyroid cancer | 0.010 | 0.035 | 0.779 | 0.037 | 0.037 | 0.321 |  − 0.004 | 0.044 | 0.932 |
Brain cancer |  − 0.011 | 0.044 | 0.808 |  − 0.017 | 0.041 | 0.682 |  − 0.010 | 0.056 | 0.858 |