Fig. 2
Neuronal-derived EV levels of synaptic proteins in patients with AD. Neuronal-derived EV levels of GAP43 (A), neurogranin (B), SNAP25 (C), and synaptotagmin 1 (D) were measured in patients with AD with MTA scores of 2, 3, and 4. A decreasing trend in the mean of synaptic proteins across MTA scores is depicted by the red lines. * Bonferroni-corrected P = 2.05 × 10−2 (A), 4.27 × 10−2 (B), 2.06 × 10−2 (C), and 2.27 × 10−2 (D) compared to MTA = 2 from one way ANOVA test. # Bonferroni-corrected P = 9.31 × 10−4 (A), 7.47 × 10−5 (B), 1.07 × 10−3 (C), and 1.22 × 10−3 (D) compared to MTA = 3 from one way ANOVA test. AD, Alzheimer’s disease; ANOVA, analysis of variance; EV, extracellular vesicle; GAP43, growth-associated protein 43; MTA, medial temporal lobe atrophy; SNAP25, synaptosome-associated protein 25