Fig. 3
CSF levels of synaptic proteins in patients with AD. CSF levels of GAP43 (A), neurogranin (B), SNAP25 (C), and synaptotagmin 1 (D) were measured in patients with AD with MTA scores of 2, 3, and 4. An increasing trend in the mean of synaptic proteins across MTA scores is depicted by the red lines. * Bonferroni-corrected P = 2.11 × 10−2 (A), P = 1.79 × 10−2 (B), 1.56 × 10−2 (C), and 3.23 × 10−3 (D) compared to MTA=2 from one way ANOVA test. # Bonferroni-corrected P = 4.87 × 10−4 (A), 1.38 × 10−5 (B), 2.52 × 10−4 (C), and 1.65 × 10−5 (D) compared to MTA = 3 from one way ANOVA test. AD, Alzheimer’s disease; ANOVA, analysis of variance; CSF, cerebrospinal fluid; GAP43, growth-associated protein 43; MTA, medial temporal lobe atrophy; SNAP25, synaptosome-associated protein 25