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Fig. 7 | BMC Medicine

Fig. 7

From: Delivering synaptic protein mRNAs via extracellular vesicles ameliorates cognitive impairment in a mouse model of Alzheimer’s disease

Fig. 7

Improvement of memory performance in 5×FAD mice following EV treatment. A Representative trajectories of each group in the probe test of MWM. B NOR test was performed 1 month after treatment. C NOL test was performed 1 month after treatment. D The parameters of escape latency were recorded for 5 days to assess the cognitive function of mice. E The time spent in the correct quadrant was recorded in the probe test of MWM. * P < 0.05, 5×FAD+EVs-TNGS compared to 5×FAD+EVs. EVs, extracellular vesicles; EVs-TNGS, extracellular vesicles targeting neural cells overexpressing growth-associated protein 43 and synaptosome-associated protein 25; MWM, Morris water maze; NOR, novel object recognition; NOL, novel object location; WT, wild-type

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BMC Medicine

ISSN: 1741-7015

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