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Fig. 8 | BMC Medicine

Fig. 8

From: Delivering synaptic protein mRNAs via extracellular vesicles ameliorates cognitive impairment in a mouse model of Alzheimer’s disease

Fig. 8

Increase in levels of GAP43 and SNAP25 in the 5×FAD mouse brains treated with EVs-TNGS. A Upregulation of Gap43 mRNA was detected using RT-qPCR in EV-TNGS-treated hippocampal tissues. B Upregulation of Snap25 mRNA was detected using RT-qPCR in EV-TNGS-treated hippocampal tissues. C–E Representative Western blots (C) and their quantitative assessment (D and E) show protein levels of GAP43 (C and D) and SNAP25 (C and E) in EV-TNGS-treated hippocampal tissues. EVs, extracellular vesicles; EVs-TNGS, extracellular vesicles targeting neural cells overexpressing Gap43 and Snap25; GAP43, growth-associated protein 43; RT-qPCR, real-time quantitative reverse transcription-polymerase chain reaction; SNAP25, synaptosome-associated protein 25; WT, wild-type

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BMC Medicine

ISSN: 1741-7015

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