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  1. Minireview

    Non-alcoholic fatty liver disease

    Non-alcoholic fatty liver disease has emerged a major challenge because of it prevalence, difficulties in diagnosis, complex pathogenesis, and lack of approved therapies. As the burden of hepatitis C abates ov...

    Brent A. Neuschwander-Tetri

    BMC Medicine 2017 15:45

    Published on: 28 February 2017

  2. Review

    Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease: update on clinical, diagnostic, and management aspects

    Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common and best known monogenic small vessel disease. Here, we review the clinical, neuroimaging...

    Ilaria Di Donato, Silvia Bianchi, Nicola De Stefano, Martin Dichgans, Maria Teresa Dotti, Marco Duering, Eric Jouvent, Amos D. Korczyn, Saskia A. J. Lesnik-Oberstein, Alessandro Malandrini, Hugh S. Markus, Leonardo Pantoni, Silvana Penco, Alessandra Rufa, Osman Sinanović, Dragan Stojanov…

    BMC Medicine 2017 15:41

    Published on: 24 February 2017

  3. Research article

    Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach

    Salivary (AMY1) and pancreatic (AMY2) amylases hydrolyze starch. Copy number of AMY1A (encoding AMY1) was reported to be higher in populations with a high-starch diet and reduced in obese people. These results ba...

    Amélie Bonnefond, Loïc Yengo, Aurélie Dechaume, Mickaël Canouil, Maxime Castelain, Estelle Roger, Frédéric Allegaert, Robert Caiazzo, Violeta Raverdy, Marie Pigeyre, Abdelilah Arredouani, Jean-Michel Borys, Claire Lévy-Marchal, Jacques Weill, Ronan Roussel, Beverley Balkau…

    BMC Medicine 2017 15:37

    Published on: 23 February 2017

  4. Research article

    Abnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects

    Human skeletal muscle stem cells are important for muscle regeneration. However, the combined genome-wide DNA methylation and expression changes taking place during adult myogenesis have not been described in ...

    Cajsa Davegårdh, Christa Broholm, Alexander Perfilyev, Tora Henriksen, Sonia García-Calzón, Lone Peijs, Ninna Schiøler Hansen, Petr Volkov, Rasmus Kjøbsted, Jørgen F. P. Wojtaszewski, Maria Pedersen, Bente Klarlund Pedersen, Dov B. Ballak, Charles A. Dinarello, Bas Heinhuis, Leo A. B. Joosten…

    BMC Medicine 2017 15:39

    Published on: 22 February 2017

  5. Commentary

    When is proton pump inhibitor use appropriate?

    Proton pump inhibitor (PPI) therapy is commonly used outside of Food and Drug Administration indication for a broad range of conditions such as extra-esophageal reflux and PPI-responsive esophageal eosinophili...

    Rena Yadlapati and Peter J. Kahrilas

    BMC Medicine 2017 15:36

    Published on: 21 February 2017

  6. Research article

    Pain relief that matters to patients: systematic review of empirical studies assessing the minimum clinically important difference in acute pain

    The minimum clinically important difference (MCID) is used to interpret the clinical relevance of results reported by trials and meta-analyses as well as to plan sample sizes in new studies. However, there is ...

    Mette Frahm Olsen, Eik Bjerre, Maria Damkjær Hansen, Jørgen Hilden, Nino Emanuel Landler, Britta Tendal and Asbjørn Hróbjartsson

    BMC Medicine 2017 15:35

    Published on: 20 February 2017

  7. Research article

    Intranasal oxytocin reduces provoked symptoms in female patients with posttraumatic stress disorder despite exerting sympathomimetic and positive chronotropic effects in a randomized controlled trial

    Posttraumatic stress disorder (PTSD) is a severe psychiatric disease accompanied by neuroendocrine changes such as adrenergic overdrive and hence an elevated cardiovascular morbidity. Current pharmacotherapeut...

    M. Sack, D. Spieler, L. Wizelman, G. Epple, J. Stich, M. Zaba and U. Schmidt

    BMC Medicine 2017 15:40

    Published on: 17 February 2017

  8. Research article

    Impact of gut hormone FGF-19 on type-2 diabetes and mitochondrial recovery in a prospective study of obese diabetic women undergoing bariatric surgery

    The ileal-derived hormone, fibroblast growth factor 19 (FGF-19), may promote weight loss and facilitate type-2 diabetes mellitus remission in bariatric surgical patients. We investigated the effect of differen...

    Lucia Martinez de la Escalera, Ioannis Kyrou, Jana Vrbikova, Voitech Hainer, Petra Sramkova, Martin Fried, Milan K. Piya, Sudhesh Kumar, Gyanendra Tripathi and Philip G. McTernan

    BMC Medicine 2017 15:34

    Published on: 16 February 2017

  9. Research article

    Financial barriers and adverse clinical outcomes among patients with cardiovascular-related chronic diseases: a cohort study

    Some patients with cardiovascular-related chronic diseases such as diabetes and heart disease report financial barriers to achieving optimal health. Previous surveys report that the perception of having a fina...

    David J. T. Campbell, Braden J. Manns, Robert G. Weaver, Brenda R. Hemmelgarn, Kathryn M. King-Shier and Claudia Sanmartin

    BMC Medicine 2017 15:33

    Published on: 15 February 2017

  10. Research article

    The effect of an antenatal lifestyle intervention in overweight and obese women on circulating cardiometabolic and inflammatory biomarkers: secondary analyses from the LIMIT randomised trial

    Maternal overweight and obesity during pregnancy is associated with insulin resistance, hyperglycaemia, hyperlipidaemia and a low-grade state of chronic inflammation. The aim of this pre-specified analysis of ...

    Lisa J. Moran, Louise M. Fraser, Tulika Sundernathan, Andrea R. Deussen, Jennie Louise, Lisa N. Yelland, Rosalie M. Grivell, Anne Macpherson, Matthew W. Gillman, Jeffrey S. Robinson, Julie A. Owens and Jodie M. Dodd

    BMC Medicine 2017 15:32

    Published on: 14 February 2017

  11. Review

    Ultrasound and dynamic functional imaging in vascular cognitive impairment and Alzheimer’s disease

    The vascular contributions to neurodegeneration and neuroinflammation may be assessed by magnetic resonance imaging (MRI) and ultrasonography (US). This review summarises the methodology for these widely avail...

    Branko Malojcic, Panteleimon Giannakopoulos, Farzaneh A. Sorond, Elsa Azevedo, Marina Diomedi, Janja Pretnar Oblak, Nicola Carraro, Marina Boban, Laszlo Olah, Stephan J. Schreiber, Aleksandra Pavlovic, Zsolt Garami, Nantan M. Bornstein and Bernhard Rosengarten

    BMC Medicine 2017 15:27

    Published on: 9 February 2017

  12. Research article

    Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort

    Circulating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL)...

    Renée T. Fortner, Danja Sarink, Helena Schock, Theron Johnson, Anne Tjønneland, Anja Olsen, Kim Overvad, Aurélie Affret, Mathilde His, Marie-Christine Boutron-Ruault, Heiner Boeing, Antonia Trichopoulou, Androniki Naska, Philippos Orfanos, Domenico Palli, Sabina Sieri…

    BMC Medicine 2017 15:26

    Published on: 8 February 2017

  13. Research article

    Comparison of the effects of fibrates versus statins on plasma lipoprotein(a) concentrations: a systematic review and meta-analysis of head-to-head randomized controlled trials

    Raised plasma lipoprotein(a) (Lp(a)) concentration is an independent and causal risk factor for atherosclerotic cardiovascular disease. Several types of pharmacological approaches are under evaluation for thei...

    Amirhossein Sahebkar, Luis E. Simental-Mendía, Gerald F. Watts, Maria-Corina Serban and Maciej Banach

    BMC Medicine 2017 15:22

    Published on: 3 February 2017

  14. Research article

    What is the association of hypothyroidism with risks of cardiovascular events and mortality? A meta-analysis of 55 cohort studies involving 1,898,314 participants

    Whether hypothyroidism is an independent risk factor for cardiovascular events is still disputed. We aimed to assess the association between hypothyroidism and risks of cardiovascular events and mortality.

    Yu Ning, Yun J. Cheng, Li J. Liu, Jaskanwal D. S. Sara, Zhi Y. Cao, Wei P. Zheng, Tian S. Zhang, Hui J. Han, Zhen Y. Yang, Yi Zhang, Fei L. Wang, Rui Y. Pan, Jie L. Huang, Ling L. Wu, Ming Zhang and Yong X. Wei

    BMC Medicine 2017 15:21

    Published on: 2 February 2017

  15. Research article

    Which patients with advanced respiratory disease die in hospital? A 14-year population-based study of trends and associated factors

    Strategies in many countries have sought to improve palliative care and reduce hospital deaths for non-cancer patients, but their effects are not evaluated. We aimed to determine the trends and factors associa...

    Irene J. Higginson, Charles C. Reilly, Sabrina Bajwah, Matthew Maddocks, Massimo Costantini and Wei Gao

    BMC Medicine 2017 15:19

    Published on: 1 February 2017

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