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  1. Research article

    Application of real-time global media monitoring and ‘derived questions’ for enhancing communication by regulatory bodies: the case of human papillomavirus vaccines

    The benefit-risk balance of vaccines is regularly debated by the public, but the utility of media monitoring for regulatory bodies is unclear. A media monitoring study was conducted at the European Medicines A...

    Priya Bahri, Julianna Fogd, Daniel Morales and Xavier Kurz

    BMC Medicine 2017 15:91

    Published on: 2 May 2017

  2. Research article

    Disease management in the treatment of patients with chronic heart failure who have universal access to health care: a randomized controlled trial

    The efficacy of disease management programs in improving the outcome of heart failure patients remains uncertain and may vary across health systems. This study explores whether a countrywide disease management...

    Ofra Kalter-Leibovici, Dov Freimark, Laurence S. Freedman, Galit Kaufman, Arnona Ziv, Havi Murad, Michal Benderly, Barbara G. Silverman, Nurit Friedman, Tali Cukierman-Yaffe, Elad Asher, Avishay Grupper, Dorit Goldman, Miriam Amitai, Shlomi Matetzky, Mordechai Shani…

    BMC Medicine 2017 15:90

    Published on: 1 May 2017

  3. Research article

    Daily home fortification with iron as ferrous fumarate versus NaFeEDTA: a randomised, placebo-controlled, non-inferiority trial in Kenyan children

    We aimed to show the non-inferiority of home fortification with a daily dose of 3 mg iron in the form of iron as ferric sodium ethylenediaminetetraacetate (NaFeEDTA) compared with 12.5 mg iron as encapsulated ...

    Emily M. Teshome, Pauline E. A. Andang’o, Victor Osoti, Sofie R. Terwel, Walter Otieno, Ayşe Y. Demir, Andrew M. Prentice and Hans Verhoef

    BMC Medicine 2017 15:89

    Published on: 28 April 2017

  4. Research article

    The relative importance of large problems far away versus small problems closer to home: insights into limiting the spread of antimicrobial resistance in England

    To combat the spread of antimicrobial resistance (AMR), hospitals are advised to screen high-risk patients for carriage of antibiotic-resistant bacteria on admission. This often includes patients previously ad...

    Tjibbe Donker, Katherine L. Henderson, Katie L. Hopkins, Andrew R. Dodgson, Stephanie Thomas, Derrick W. Crook, Tim E. A. Peto, Alan P. Johnson, Neil Woodford, A. Sarah Walker and Julie V. Robotham

    BMC Medicine 2017 15:86

    Published on: 27 April 2017

  5. Research article

    Effects of unconditional cash transfers on the outcome of treatment for severe acute malnutrition (SAM): a cluster-randomised trial in the Democratic Republic of the Congo

    Cash transfer programs (CTPs) aim to strengthen financial security for vulnerable households. This potentially enables improvements in diet, hygiene, health service access and investment in food production or ...

    Emmanuel Grellety, Pélagie Babakazo, Amina Bangana, Gustave Mwamba, Ines Lezama, Noël Marie Zagre and Eric-Alain Ategbo

    BMC Medicine 2017 15:87

    Published on: 26 April 2017

  6. Research article

    Relative contribution of type 1 and type 2 diabetes loci to the genetic etiology of adult-onset, non-insulin-requiring autoimmune diabetes

    In adulthood, autoimmune diabetes can present as non-insulin-requiring diabetes, termed as ‘latent autoimmune diabetes in adults’ (LADA). In this study, we investigated established type 1 diabetes (T1D) and ty...

    Rajashree Mishra, Alessandra Chesi, Diana L. Cousminer, Mohammad I. Hawa, Jonathan P. Bradfield, Kenyaita M. Hodge, Vanessa C. Guy, Hakon Hakonarson, Didac Mauricio, Nanette C. Schloot, Knud B. Yderstræde, Benjamin F. Voight, Stanley Schwartz, Bernhard O. Boehm, Richard David Leslie and Struan F. A. Grant

    BMC Medicine 2017 15:88

    Published on: 25 April 2017

  7. Research article

    Efavirenz-based simplification after successful early lopinavir-boosted-ritonavir-based therapy in HIV-infected children in Burkina Faso and Côte d’Ivoire: the MONOD ANRS 12206 non-inferiority randomised trial

    The 2016 World Health Organization guidelines recommend all children <3 years start antiretroviral therapy (ART) on protease inhibitor-based regimens. But lopinavir/ritonavir (LPV/r) syrup has many challenges ...

    Désiré Lucien Dahourou, Madeleine Amorissani-Folquet, Karen Malateste, Clarisse Amani-Bosse, Malik Coulibaly, Carole Seguin-Devaux, Thomas Toni, Rasmata Ouédraogo, Stéphane Blanche, Caroline Yonaba, François Eboua, Philippe Lepage, Divine Avit, Sylvie Ouédraogo, Philippe Van de Perre, Sylvie N’Gbeche…

    BMC Medicine 2017 15:85

    Published on: 24 April 2017

  8. Research article

    Percutaneous intervention versus coronary artery bypass graft surgery in left main coronary artery stenosis: a systematic review and meta-analysis

    The optimal revascularization technique in patients with left main coronary artery disease (CAD) remains controversial. We aimed to compare the long-term performance of percutaneous coronary intervention (PCI)...

    Xin-Lin Zhang, Qing-Qing Zhu, Jing-Jing Yang, Yu-Han Chen, Yang Li, Su-Hui Zhu, Jun Xie, Lian Wang, Li-Na Kang and Biao Xu

    BMC Medicine 2017 15:84

    Published on: 21 April 2017

  9. Research article

    Accuracy of low-density lipoprotein cholesterol estimation at very low levels

    As the approach to low-density lipoprotein cholesterol (LDL-C) lowering becomes increasingly intensive, accurate assessment of LDL-C at very low levels warrants closer attention in individualized clinical effi...

    Renato Quispe, Aditya Hendrani, Mohamed B. Elshazly, Erin D. Michos, John W. McEvoy, Michael J. Blaha, Maciej Banach, Krishnaji R. Kulkarni, Peter P. Toth, Josef Coresh, Roger S. Blumenthal, Steven R. Jones and Seth S. Martin

    BMC Medicine 2017 15:83

    Published on: 20 April 2017

  10. Research article

    Antidepressant use and cognitive decline in community-dwelling elderly people – The Three-City Cohort

    Cognitive impairment is very common in late-life depression, principally affecting executive skills and information processing speed. The aim of the study was to examine the effect of antidepressant treatment ...

    Isabelle Carrière, Joanna Norton, Amandine Farré, Marilyn Wyart, Christophe Tzourio, Pernelle Noize, Karine Pérès, Annie Fourrier-Réglat, Karen Ritchie and Marie Laure Ancelin

    BMC Medicine 2017 15:81

    Published on: 19 April 2017

  11. Opinion

    The new field of ‘precision psychiatry’

    Precision medicine is a new and important topic in psychiatry. Psychiatry has not yet benefited from the advanced diagnostic and therapeutic technologies that form an integral part of other clinical specialtie...

    Brisa S. Fernandes, Leanne M. Williams, Johann Steiner, Marion Leboyer, André F. Carvalho and Michael Berk

    BMC Medicine 2017 15:80

    Published on: 13 April 2017

  12. Research article

    S100β as a serum marker in endocrine resistant breast cancer

    Endocrine therapy is standard treatment for estrogen receptor (ER)-positive breast cancer. However, its efficacy is limited by intrinsic and acquired resistance. Here the potential of S100β as a biomarker and ...

    Sara Charmsaz, Éamon Hughes, Fiona T. Bane, Paul Tibbitts, Marie McIlroy, Christopher Byrne, Sinéad Cocchiglia, Jean McBryan, Bryan T. Hennessy, Róisín M. Dwyer, Michael J. Kerin, Arnold D. Hill and Leonie S. Young

    BMC Medicine 2017 15:79

    Published on: 12 April 2017

  13. Research article

    Incentivised chronic disease management and the inverse equity hypothesis: findings from a longitudinal analysis of Scottish primary care practice-level data

    The inverse equity hypothesis asserts that new health policies initially widen inequality, then attenuate inequalities over time. Since 2004, the UK’s pay-for-performance scheme for chronic disease management ...

    Richard Lowrie, Alex McConnachie, Andrea E. Williamson, Evangelos Kontopantelis, Marie Forrest, Norman Lannigan, Stewart W. Mercer and Frances S. Mair

    BMC Medicine 2017 15:77

    Published on: 11 April 2017

  14. Research article

    Patterns of care and outcomes of patients with METAstatic soft tissue SARComa in a real-life setting: the METASARC observational study

    Well-designed observational studies of individuals with rare tumors are needed to improve patient care, clinical investigations, and the education of healthcare professionals.

    Marion Savina, Axel Le Cesne, Jean-Yves Blay, Isabelle Ray-Coquard, Olivier Mir, Maud Toulmonde, Sophie Cousin, Philippe Terrier, Dominique Ranchere-Vince, Pierre Meeus, Eberhard Stoeckle, Charles Honoré, Paul Sargos, Marie-Pierre Sunyach, Cécile Le Péchoux, Antoine Giraud…

    BMC Medicine 2017 15:78

    Published on: 10 April 2017

  15. Review

    Emerging concepts in liquid biopsies

    Characterizing and monitoring tumor genomes with blood samples could achieve significant improvements in precision medicine. As tumors shed parts of themselves into the circulation, analyses of circulating tum...

    Samantha Perakis and Michael R. Speicher

    BMC Medicine 2017 15:75

    Published on: 6 April 2017

  16. Research article

    Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: a nested case-control study

    Leakage of bacterial products across the gut barrier may play a role in liver diseases which often precede the development of liver cancer. However, human studies, particularly from prospective settings, are l...

    Veronika Fedirko, Hao Quang Tran, Andrew T. Gewirtz, Magdalena Stepien, Antonia Trichopoulou, Krasimira Aleksandrova, Anja Olsen, Anne Tjønneland, Kim Overvad, Franck Carbonnel, Marie-Christine Boutron-Ruault, Gianluca Severi, Tilman Kühn, Rudolf Kaaks, Heiner Boeing, Christina Bamia…

    BMC Medicine 2017 15:72

    Published on: 4 April 2017

  17. Research article

    Treatment duration of febrile urinary tract infection: a pragmatic randomized, double-blind, placebo-controlled non-inferiority trial in men and women

    In adults with febrile urinary tract infection (fUTI), data on optimal treatment duration in patients other than non-pregnant women without comorbidities are lacking.

    Cees van Nieuwkoop, Willize E. van der Starre, Janneke E. Stalenhoef, Anna M. van Aartrijk, Tanny J. K. van der Reijden, Albert M. Vollaard, Nathalie M. Delfos, Jan W. van ’t Wout, Jeanet W. Blom, Ida C. Spelt, Eliane M. S. Leyten, Ted Koster, Hans C. Ablij, Martha T. van der Beek, Mirjam J. Knol and Jaap T. van Dissel

    BMC Medicine 2017 15:70

    Published on: 3 April 2017

  18. Research article

    Prediction of complications in early-onset pre-eclampsia (PREP): development and external multinational validation of prognostic models

    Unexpected clinical deterioration before 34 weeks gestation is an undesired course in early-onset pre-eclampsia. To safely prolong preterm gestation, accurate and timely prediction of complications is required.

    Shakila Thangaratinam, John Allotey, Nadine Marlin, Julie Dodds, Fiona Cheong-See, Peter von Dadelszen, Wessel Ganzevoort, Joost Akkermans, Sally Kerry, Ben W. Mol, Karl G. M. Moons, Richard D. Riley and Khalid S. Khan

    BMC Medicine 2017 15:68

    Published on: 30 March 2017

  19. Research article

    Use of whole-genome sequencing to distinguish relapse from reinfection in a completed tuberculosis clinical trial

    RIFAQUIN was a tuberculosis chemotherapy trial in southern Africa including regimens with high-dose rifapentine with moxifloxacin. Here, the application of whole-genome sequencing (WGS) is evaluated within RIF...

    Adam A. Witney, Anna L. E. Bateson, Amina Jindani, Patrick P. J. Phillips, David Coleman, Neil G. Stoker, Philip D. Butcher and Timothy D. McHugh

    BMC Medicine 2017 15:71

    Published on: 29 March 2017

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