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  1. Research article

    Incentivised chronic disease management and the inverse equity hypothesis: findings from a longitudinal analysis of Scottish primary care practice-level data

    The inverse equity hypothesis asserts that new health policies initially widen inequality, then attenuate inequalities over time. Since 2004, the UK’s pay-for-performance scheme for chronic disease management ...

    Richard Lowrie, Alex McConnachie, Andrea E. Williamson, Evangelos Kontopantelis, Marie Forrest, Norman Lannigan, Stewart W. Mercer and Frances S. Mair

    BMC Medicine 2017 15:77

    Published on: 11 April 2017

  2. Research article

    Patterns of care and outcomes of patients with METAstatic soft tissue SARComa in a real-life setting: the METASARC observational study

    Well-designed observational studies of individuals with rare tumors are needed to improve patient care, clinical investigations, and the education of healthcare professionals.

    Marion Savina, Axel Le Cesne, Jean-Yves Blay, Isabelle Ray-Coquard, Olivier Mir, Maud Toulmonde, Sophie Cousin, Philippe Terrier, Dominique Ranchere-Vince, Pierre Meeus, Eberhard Stoeckle, Charles Honoré, Paul Sargos, Marie-Pierre Sunyach, Cécile Le Péchoux, Antoine Giraud…

    BMC Medicine 2017 15:78

    Published on: 10 April 2017

  3. Review

    Emerging concepts in liquid biopsies

    Characterizing and monitoring tumor genomes with blood samples could achieve significant improvements in precision medicine. As tumors shed parts of themselves into the circulation, analyses of circulating tum...

    Samantha Perakis and Michael R. Speicher

    BMC Medicine 2017 15:75

    Published on: 6 April 2017

  4. Research article

    Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: a nested case-control study

    Leakage of bacterial products across the gut barrier may play a role in liver diseases which often precede the development of liver cancer. However, human studies, particularly from prospective settings, are l...

    Veronika Fedirko, Hao Quang Tran, Andrew T. Gewirtz, Magdalena Stepien, Antonia Trichopoulou, Krasimira Aleksandrova, Anja Olsen, Anne Tjønneland, Kim Overvad, Franck Carbonnel, Marie-Christine Boutron-Ruault, Gianluca Severi, Tilman Kühn, Rudolf Kaaks, Heiner Boeing, Christina Bamia…

    BMC Medicine 2017 15:72

    Published on: 4 April 2017

  5. Research article

    Treatment duration of febrile urinary tract infection: a pragmatic randomized, double-blind, placebo-controlled non-inferiority trial in men and women

    In adults with febrile urinary tract infection (fUTI), data on optimal treatment duration in patients other than non-pregnant women without comorbidities are lacking.

    Cees van Nieuwkoop, Willize E. van der Starre, Janneke E. Stalenhoef, Anna M. van Aartrijk, Tanny J. K. van der Reijden, Albert M. Vollaard, Nathalie M. Delfos, Jan W. van ’t Wout, Jeanet W. Blom, Ida C. Spelt, Eliane M. S. Leyten, Ted Koster, Hans C. Ablij, Martha T. van der Beek, Mirjam J. Knol and Jaap T. van Dissel

    BMC Medicine 2017 15:70

    Published on: 3 April 2017

  6. Research article

    Prediction of complications in early-onset pre-eclampsia (PREP): development and external multinational validation of prognostic models

    Unexpected clinical deterioration before 34 weeks gestation is an undesired course in early-onset pre-eclampsia. To safely prolong preterm gestation, accurate and timely prediction of complications is required.

    Shakila Thangaratinam, John Allotey, Nadine Marlin, Julie Dodds, Fiona Cheong-See, Peter von Dadelszen, Wessel Ganzevoort, Joost Akkermans, Sally Kerry, Ben W. Mol, Karl G. M. Moons, Richard D. Riley and Khalid S. Khan

    BMC Medicine 2017 15:68

    Published on: 30 March 2017

  7. Research article

    Use of whole-genome sequencing to distinguish relapse from reinfection in a completed tuberculosis clinical trial

    RIFAQUIN was a tuberculosis chemotherapy trial in southern Africa including regimens with high-dose rifapentine with moxifloxacin. Here, the application of whole-genome sequencing (WGS) is evaluated within RIF...

    Adam A. Witney, Anna L. E. Bateson, Amina Jindani, Patrick P. J. Phillips, David Coleman, Neil G. Stoker, Philip D. Butcher and Timothy D. McHugh

    BMC Medicine 2017 15:71

    Published on: 29 March 2017

  8. Research article

    The effect of intervening hospitalizations on the benefit of structured physical activity in promoting independent mobility among community-living older persons: secondary analysis of a randomized controlled trial

    Among older persons, disability is often precipitated by intervening illnesses and injuries leading to hospitalization. In the Lifestyle Interventions and Independence for Elders (LIFE) Study, a structured mod...

    Thomas M. Gill, Daniel P. Beavers, Jack M. Guralnik, Marco Pahor, Roger A. Fielding, Michelle Hauser, Todd M. Manini, Anthony P. Marsh, Mary M. McDermott, Anne B. Newman, Heather G. Allore and Michael E. Miller

    BMC Medicine 2017 15:65

    Published on: 28 March 2017

  9. Research article

    The association between the day of the week of milestones in the care pathway of patients with hip fracture and 30-day mortality: findings from a prospective national registry – The National Hip Fracture Database of England and Wales

    Recent publications indicate increased mortality in patients admitted to hospital at the weekend, but these findings may be subject to inadequate adjustment for case-mix and the complexities of resource provis...

    Adrian Sayers, Michael R. Whitehouse, James R. Berstock, Karen A. Harding, Michael B. Kelly and Timothy J. Chesser

    BMC Medicine 2017 15:62

    Published on: 27 March 2017

  10. Research article

    Can incontinence be cured? A systematic review of cure rates

    Incontinence constitutes a major health problem affecting millions of people worldwide. The present study aims to assess cure rates from treating urinary (UI) or fecal incontinence (FI) and the number of peopl...

    Rob Riemsma, Suzanne Hagen, Ruth Kirschner-Hermanns, Christine Norton, Helle Wijk, Karl-Erik Andersson, Christopher Chapple, Julian Spinks, Adrian Wagg, Edward Hutt, Kate Misso, Sohan Deshpande, Jos Kleijnen and Ian Milsom

    BMC Medicine 2017 15:63

    Published on: 24 March 2017

  11. Research article

    Preclinical evaluation of a TEX101 protein ELISA test for the differential diagnosis of male infertility

    TEX101 is a cell membrane protein exclusively expressed by testicular germ cells and shed into seminal plasma. We previously verified human TEX101 as a biomarker for the differential diagnosis of azoospermia, ...

    Dimitrios Korbakis, Christina Schiza, Davor Brinc, Antoninus Soosaipillai, Theano D. Karakosta, Christine Légaré, Robert Sullivan, Brendan Mullen, Keith Jarvi, Eleftherios P. Diamandis and Andrei P. Drabovich

    BMC Medicine 2017 15:60

    Published on: 23 March 2017

  12. Research article

    Diagnostic accuracy, incremental yield and prognostic value of Determine TB-LAM for routine diagnostic testing for tuberculosis in HIV-infected patients requiring acute hospital admission in South Africa: a prospective cohort

    We previously reported that one-third of HIV-positive adults requiring medical admission to a South African district hospital had laboratory-confirmed tuberculosis (TB) and that almost two-thirds of cases coul...

    Stephen D. Lawn, Andrew D. Kerkhoff, Rosie Burton, Charlotte Schutz, Andrew Boulle, Monica Vogt, Ankur Gupta-Wright, Mark P. Nicol and Graeme Meintjes

    BMC Medicine 2017 15:67

    Published on: 21 March 2017

  13. Research article

    Are potentially clinically meaningful benefits misinterpreted in cardiovascular randomized trials? A systematic examination of statistical significance, clinical significance, and authors’ conclusions

    While journals and reporting guidelines recommend the presentation of confidence intervals, many authors adhere strictly to statistically significant testing. Our objective was to determine what proportions of...

    G. Michael Allan, Caitlin R. Finley, James McCormack, Vivek Kumar, Simon Kwong, Emelie Braschi, Christina Korownyk, Michael R. Kolber, Adriennne J. Lindblad, Oksana Babenko and Scott Garrison

    BMC Medicine 2017 15:58

    Published on: 20 March 2017

  14. Research article

    Predicting fitness to practise events in international medical graduates who registered as UK doctors via the Professional and Linguistic Assessments Board (PLAB) system: a national cohort study

    International medical graduates working in the UK are more likely to be censured in relation to fitness to practise compared to home graduates. Performance on the General Medical Council’s (GMC’s) Professional...

    Paul A. Tiffin, Lewis W. Paton, Lazaro M. Mwandigha, John C. McLachlan and Jan Illing

    BMC Medicine 2017 15:66

    Published on: 20 March 2017

  15. Research article

    Systematic meta-review of supported self-management for asthma: a healthcare perspective

    Supported self-management has been recommended by asthma guidelines for three decades; improving current suboptimal implementation will require commitment from professionals, patients and healthcare organisati...

    Hilary Pinnock, Hannah L. Parke, Maria Panagioti, Luke Daines, Gemma Pearce, Eleni Epiphaniou, Peter Bower, Aziz Sheikh, Chris J. Griffiths and Stephanie J. C. Taylor

    BMC Medicine 2017 15:64

    Published on: 17 March 2017

  16. Research article

    Metabolomics approaches in pancreatic adenocarcinoma: tumor metabolism profiling predicts clinical outcome of patients

    Pancreatic adenocarcinomas (PAs) have very poor prognoses even when surgery is possible. Currently, there are no tissular biomarkers to predict long-term survival in patients with PA. The aims of this study we...

    S. Battini, F. Faitot, A. Imperiale, A. E. Cicek, C. Heimburger, G. Averous, P. Bachellier and I. J. Namer

    BMC Medicine 2017 15:56

    Published on: 16 March 2017

  17. Research article

    Potential predatory and legitimate biomedical journals: can you tell the difference? A cross-sectional comparison

    The Internet has transformed scholarly publishing, most notably, by the introduction of open access publishing. Recently, there has been a rise of online journals characterized as ‘predatory’, which actively s...

    Larissa Shamseer, David Moher, Onyi Maduekwe, Lucy Turner, Virginia Barbour, Rebecca Burch, Jocalyn Clark, James Galipeau, Jason Roberts and Beverley J. Shea

    BMC Medicine 2017 15:28

    Published on: 16 March 2017

  18. Minireview

    Elimination of Hepatitis B: Is It a Mission Possible?

    Chronic hepatitis B virus (HBV) infection is a global public health issue. Although the disease cannot be cured effectively, disease management has been improved over the past decade. The introduction of poten...

    Tai-Chung Tseng and Jia-Horng Kao

    BMC Medicine 2017 15:53

    Published on: 15 March 2017

  19. Erratum

    Erratum to: Characteristics and knowledge synthesis approach for 456 network meta-analyses: a scoping review

    Wasifa Zarin, Areti Angeliki Veroniki, Vera Nincic, Afshin Vafaei, Emily Reynen, Sanober S. Motiwala, Jesmin Antony, Shannon M. Sullivan, Patricia Rios, Caitlin Daly, Joycelyne Ewusie, Maria Petropoulou, Adriani Nikolakopoulou, Anna Chaimani, Georgia Salanti, Sharon E. Straus…

    BMC Medicine 2017 15:61

    Published on: 14 March 2017

    The original article was published in BMC Medicine 2017 15:3

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