Effect of rosiglitazone (RGZ) on perinatal nicotine exposure-induced alterations in mixed gender offspring pulmonary function. Compared to the control group, with nicotine administration there was a significant increase in resistance and a significant decrease in compliance of the lung following a Mch challenge, both of which were blocked by concomitant RGZ administration. Values are means ± SE. n = 10 to 12 for each group. **P < 0.01, versus control; ##P < 0.01, versus nicotine group. Mch, methacholine.