Managing the outcome of heart failure patients is not always effective and can vary according to in different health systems. In a multicenter open-label trial, 1360 patients were recruited after hospitalization for heart failure, and assigned to receive either disease management or usual care. Patients assigned to disease management showed lower depression score and better health-related quality of life at follow up. However, the intervention was not superior to usual care with respect to the primary outcome, indicating that a disease-centered approach may not significantly impact hospital admissions and mortality in chronic heart failure patients with universal access to care.

Read more

BMC Medicine is pleased to announce the launch of a special thematic collection on landmark oncology trials. This article collection includes carefully selected articles from invited experts on landmark trials that had the most substantial influence on the clinical practice or provided some critical evidence that enhanced our understanding in this field. It will also feature current topics in the trial design. The collection launches with an editorial by our Editorial Board Members, Prof. Helena Earl, Prof. Stefano Molica and Prof. Piotr Rutkowski.

Read more