Managing the outcome of heart failure patients is not always effective and can vary according to in different health systems. In a multicenter open-label trial, 1360 patients were recruited after hospitalization for heart failure, and assigned to receive either disease management or usual care. Patients assigned to disease management showed lower depression score and better health-related quality of life at follow up. However, the intervention was not superior to usual care with respect to the primary outcome, indicating that a disease-centered approach may not significantly impact hospital admissions and mortality in chronic heart failure patients with universal access to care.

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Liver diseases can be caused by a multitude of factors, including genetic predisposition, infections and the environment, requiring diverse and targeted treatment options. Managing liver disease article collection in BMC Medicine aims to feature the latest findings on the management of liver diseases, welcoming the submission of original research articles on the detection, management and new treatment techniques. Invited commentaries and reviews will also be included in the collection. Submit your article by 31 July 2017.

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