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  1. Content type: Research article

    The U.S. Food and Drug Administration (FDA) often approves new drugs based on trials that use surrogate markers for endpoints, which involve certain trade-offs and may risk making erroneous inferences about th...

    Authors: Joshua D. Wallach, Oriana Ciani, Alison M. Pease, Gregg S. Gonsalves, Harlan M. Krumholz, Rod S. Taylor and Joseph S. Ross

    Citation: BMC Medicine 2018 16:45

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  2. Content type: Research article

    Insufficient sleep duration and obstructive sleep apnea, two common causes of sleep deficiency in adults, can result in excessive sleepiness, a well-recognized cause of motor vehicle crashes, although their co...

    Authors: Daniel J. Gottlieb, Jeffrey M. Ellenbogen, Matt T. Bianchi and Charles A. Czeisler

    Citation: BMC Medicine 2018 16:44

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  3. Content type: Research article

    Refugees may have an increased vulnerability to infectious diseases, and the consequences of an outbreak are more severe in a refugee camp. When an outbreak is suspected, access to clinical information is crit...

    Authors: Amanda M. Rojek, Kassiani Gkolfinopoulou, Apostolos Veizis, Angeliki Lambrou, Lyndsey Castle, Theano Georgakopoulou, Karl Blanchet, Takis Panagiotopoulos and Peter W. Horby

    Citation: BMC Medicine 2018 16:43

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  4. Content type: Research article

    An inverse relationship between allergies with glioma risk has been reported in several but not all epidemiological observational studies. We performed an analysis of genetic variants associated with atopy to ...

    Authors: Linden Disney-Hogg, Alex J. Cornish, Amit Sud, Philip J. Law, Ben Kinnersley, Daniel I. Jacobs, Quinn T. Ostrom, Karim Labreche, Jeanette E. Eckel-Passow, Georgina N. Armstrong, Elizabeth B. Claus, Dora Il’yasova, Joellen Schildkraut, Jill S. Barnholtz-Sloan, Sara H. Olson, Jonine L. Bernstein…

    Citation: BMC Medicine 2018 16:42

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  5. Content type: Research article

    Clusterin, also known as apolipoprotein J (apoJ), is one of the most abundantly expressed apolipoproteins in the brain after apolipoprotein E (apoE). Like the ε4 allele of the apolipoprotein E gene (APOE), the cl...

    Authors: Liv Tybjærg Nordestgaard, Anne Tybjærg-Hansen, Katrine Laura Rasmussen, Børge G. Nordestgaard and Ruth Frikke-Schmidt

    Citation: BMC Medicine 2018 16:39

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  6. Content type: Research article

    Since 2015, Europe has been facing an unprecedented arrival of refugees and migrants: more than one million people entered via land and sea routes. During their travels, refugees and migrants often face harsh ...

    Authors: Jihane Ben Farhat, Karl Blanchet, Pia Juul Bjertrup, Apostolos Veizis, Clément Perrin, Rebecca M. Coulborn, Philippe Mayaud and Sandra Cohuet

    Citation: BMC Medicine 2018 16:40

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  7. Content type: Research article

    Marine resources including fatty fish are important sources of n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFAs), which are important for brain development. To our knowledge, this is the first randomiz...

    Authors: Jannike Øyen, Ingrid Kvestad, Lisa Kolden Midtbø, Ingvild Eide Graff, Mari Hysing, Kjell Morten Stormark, Maria Wik Markhus, Valborg Baste, Livar Frøyland, Berthold Koletzko, Hans Demmelmair, Lisbeth Dahl, Øyvind Lie and Marian Kjellevold

    Citation: BMC Medicine 2018 16:41

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  8. Content type: Research article

    Hyperlactataemia (HL) is a biomarker of disease severity that predicts mortality in patients with sepsis and malaria. Lactate clearance (LC) during resuscitation has been shown to be a prognostic factor of sur...

    Authors: A. Aramburo, Jim Todd, Elizabeth C. George, Sarah Kiguli, Peter Olupot-Olupot, Robert O. Opoka, Charles Engoru, Samuel O. Akech, Richard Nyeko, George Mtove, Diana M. Gibb, Abdel G. Babiker and Kathryn Maitland

    Citation: BMC Medicine 2018 16:37

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  9. Content type: Research article

    Antidepressants are one of the most commonly prescribed medications in young and middle-aged adults, but there is relatively little information on their safety across a range of adverse outcomes in this age gr...

    Authors: Carol Coupland, Trevor Hill, Richard Morriss, Michael Moore, Antony Arthur and Julia Hippisley-Cox

    Citation: BMC Medicine 2018 16:36

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  10. Content type: Research article

    Acute symptomatic seizures and febrile seizures are common in children admitted to hospitals in Africa and may be markers of brain dysfunction. They may be associated with behavioural and emotional problems, b...

    Authors: Symon M. Kariuki, Amina Abubakar, Martha Kombe, Michael Kazungu, Rachael Odhiambo, Alan Stein and Charles R. J. C. Newton

    Citation: BMC Medicine 2018 16:35

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  11. Content type: Correction

    The original article [1] contains a major error whereby all rates in Table 2 are mistakenly presented as 50% of their true values; this error was caused by a miscalculation in annualising the original values t...

    Authors: Matthew J. Spittal, David M. Studdert, Ron Paterson and Marie M. Bismark

    Citation: BMC Medicine 2018 16:38

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    The original article was published in BMC Medicine 2016 14:198

  12. Content type: Research article

    External validations and comparisons of prognostic models or scores are a prerequisite for their use in routine clinical care but are lacking in most medical fields including chronic obstructive pulmonary dise...

    Authors: Beniamino Guerra, Sarah R. Haile, Bernd Lamprecht, Ana S. Ramírez, Pablo Martinez-Camblor, Bernhard Kaiser, Inmaculada Alfageme, Pere Almagro, Ciro Casanova, Cristóbal Esteban-González, Juan J. Soler-Cataluña, Juan P. de-Torres, Marc Miravitlles, Bartolome R. Celli, Jose M. Marin, Gerben ter Riet…

    Citation: BMC Medicine 2018 16:33

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  13. Content type: Debate

    There is increasing focus on the strength of primary health care systems in low and middle-income countries (LMIC). There are important roles for higher quality district hospital care within these systems. The...

    Authors: Mike English, Paul Mwaniki, Thomas Julius, Mercy Chepkirui, David Gathara, Paul O. Ouma, Peter Cherutich, Emelda A. Okiro and Robert W. Snow

    Citation: BMC Medicine 2018 16:32

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  14. Content type: Correspondence

    Adaptive designs can make clinical trials more flexible by utilising results accumulating in the trial to modify the trial’s course in accordance with pre-specified rules. Trials with an adaptive design are of...

    Authors: Philip Pallmann, Alun W. Bedding, Babak Choodari-Oskooei, Munyaradzi Dimairo, Laura Flight, Lisa V. Hampson, Jane Holmes, Adrian P. Mander, Lang’o Odondi, Matthew R. Sydes, Sofía S. Villar, James M. S. Wason, Christopher J. Weir, Graham M. Wheeler, Christina Yap and Thomas Jaki

    Citation: BMC Medicine 2018 16:29

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  15. Content type: Research article

    Despite long-lasting HIV replication control, a significant proportion of elite controller (EC) patients may experience CD4 T-cell loss. Discovering perturbations in immunological parameters could help our und...

    Authors: José M. Benito, María C. Ortiz, Agathe León, Luis A. Sarabia, José M. Ligos, María Montoya, Marcial Garcia, Ezequiel Ruiz-Mateos, Rosario Palacios, Alfonso Cabello, Clara Restrepo, Carmen Rodriguez, Jorge del Romero, Manuel Leal, María A. Muñoz-Fernández, José Alcamí…

    Citation: BMC Medicine 2018 16:30

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  16. Content type: Research article

    The purpose of this study is to validate a new five-tiered prognostic classification system to better discriminate cancer-specific mortality in men diagnosed with primary non-metastatic prostate cancer.

    Authors: V. J. Gnanapragasam, O. Bratt, K. Muir, L. S. Lee, H. H. Huang, P. Stattin and A. Lophatananon

    Citation: BMC Medicine 2018 16:31

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  17. Content type: Research article

    Depression is viewed as a major and increasing public health issue, as it causes high distress in the people experiencing it and considerable financial costs to society. Efforts are being made to reduce this b...

    Authors: Anna Fernández, Juan M. Mendive, Sonia Conejo-Cerón, Patricia Moreno-Peral, Michael King, Irwin Nazareth, Carlos Martín-Pérez, Carmen Fernández-Alonso, Antonina Rodríguez-Bayón, Jose Maria Aiarzaguena, Carmen Montón-Franco, Antoni Serrano-Blanco, Inmaculada Ibañez-Casas, Emiliano Rodríguez-Sánchez, Luis Salvador-Carulla, Paola Bully Garay…

    Citation: BMC Medicine 2018 16:28

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  18. Content type: Research article

    Multidrug-resistant tuberculosis (MDR-TB) is a growing concern in meeting global targets for TB control. In high-income low-TB-incidence countries, a disproportionate number of MDR-TB cases occur in migrant (f...

    Authors: Laura B. Nellums, Kieran Rustage, Sally Hargreaves and Jon S. Friedland

    Citation: BMC Medicine 2018 16:27

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  19. Content type: Research article

    The ability to reproduce experiments is a defining principle of science. Reproducibility of clinical research has received relatively little scientific attention. However, it is important as it may inform clin...

    Authors: Daniel J. Niven, T. Jared McCormick, Sharon E. Straus, Brenda R. Hemmelgarn, Lianne Jeffs, Tavish R. M. Barnes and Henry T. Stelfox

    Citation: BMC Medicine 2018 16:26

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  20. Content type: Commentary

    Adult-onset, or type II diabetes mellitus (T2DM) has a complex genetic architecture, from hundreds of genes with low penetrance, common susceptibility variants (e.g., TCF7L2), to a set of more than ten genes that...

    Authors: Leslie G. Biesecker

    Citation: BMC Medicine 2018 16:25

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    The original article was published in BMC Medicine 2017 15:213

  21. Content type: Research article

    Dysfunction of the circadian clock and single polymorphisms of some circadian genes have been linked to cancer susceptibility, although data are scarce and findings inconsistent. We aimed to investigate the as...

    Authors: Simone Mocellin, Saveria Tropea, Clara Benna and Carlo Riccardo Rossi

    Citation: BMC Medicine 2018 16:20

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  22. Content type: Commentary

    The therapeutic approach for the second-line treatment of patients with advanced non-small cell lung cancer (NSCLC) without actionable mutations has been revolutionized by the recent approval of new effective ...

    Authors: Alessandro Morabito

    Citation: BMC Medicine 2018 16:24

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    The original article was published in BMC Medicine 2017 15:193

  23. Content type: Research article

    Primary care provides the foundation for most modern health-care systems, and in the interests of equity, it should be resourced according to local need. We aimed to describe spatially the burden of chronic co...

    Authors: Evangelos Kontopantelis, Mamas A. Mamas, Harm van Marwijk, Andrew M. Ryan, Peter Bower, Bruce Guthrie and Tim Doran

    Citation: BMC Medicine 2018 16:19

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  24. Content type: Research article

    Comparisons of clinical trial findings in systematic reviews can be hindered by the heterogeneity of the outcomes reported. Moreover, the outcomes that matter most to patients might be underreported. A core ou...

    Authors: Jean-Baptiste Beuscart, Wilma Knol, Shane Cullinan, Claudio Schneider, Olivia Dalleur, Benoit Boland, Stefanie Thevelin, Paul A. F. Jansen, Denis O’Mahony, Nicolas Rodondi and Anne Spinewine

    Citation: BMC Medicine 2018 16:21

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