Skip to main content

Articles

Page 1 of 58

  1. Balancing the control of SARS-CoV-2 transmission with the resumption of travel is a global priority. Current recommendations include mitigation measures before, during, and after travel. Pre- and post-travel s...

    Authors: Michael A. Johansson, Hannah Wolford, Prabasaj Paul, Pamela S. Diaz, Tai-Ho Chen, Clive M. Brown, Martin S. Cetron and Francisco Alvarado-Ramy

    Citation: BMC Medicine 2021 19:94

    Content type: Research article

    Published on:

  2. More than one third of Norwegian women and men between 20 and 40 years of age have elevated cholesterol concentration. Parental metabolic health around conception or during pregnancy may affect the offspring’s...

    Authors: Linn K. L. Øyri, Martin P. Bogsrud, Jacob J. Christensen, Stine M. Ulven, Anne Lise Brantsæter, Kjetil Retterstøl, Hilde K. Brekke, Trond M. Michelsen, Tore Henriksen, Jeanine E. Roeters van Lennep, Per Magnus, Marit B. Veierød and Kirsten B. Holven

    Citation: BMC Medicine 2021 19:91

    Content type: Research article

    Published on:

  3. COVID-19 spread may have a dramatic impact in countries with vulnerable economies and limited availability of, and access to, healthcare resources and infrastructures. However, in sub-Saharan Africa, a low pre...

    Authors: Filippo Trentini, Giorgio Guzzetta, Margherita Galli, Agnese Zardini, Fabio Manenti, Giovanni Putoto, Valentina Marziano, Worku Nigussa Gamshie, Ademe Tsegaye, Alessandro Greblo, Alessia Melegaro, Marco Ajelli, Stefano Merler and Piero Poletti

    Citation: BMC Medicine 2021 19:89

    Content type: Research article

    Published on:

  4. An accurate and comprehensive assessment of harms is a fundamental part of an accurate weighing of benefits and harms of an intervention when making treatment decisions; however, harms are known to be underrep...

    Authors: Asger S. Paludan-Müller, Perrine Créquit and Isabelle Boutron

    Citation: BMC Medicine 2021 19:88

    Content type: Research article

    Published on:

  5. The use of prenatal dexamethasone remains controversial. Our recent studies found that prenatal dexamethasone exposure can induce maternal intrahepatic cholestasis and have a lasting adverse influence on bile ...

    Authors: Wen Huang, Jin Zhou, Juanjuan Guo, Wen Hu, Guanghui Chen, Bin Li, Yajie Wen, Yimin Jiang, Kaili Fu, Huichang Bi, Yuanzhen Zhang and Hui Wang

    Citation: BMC Medicine 2021 19:87

    Content type: Research article

    Published on:

  6. Machine learning (ML) is increasingly used in research for subtype definition and risk prediction, particularly in cardiovascular diseases. No existing ML models are routinely used for cardiovascular disease m...

    Authors: Amitava Banerjee, Suliang Chen, Ghazaleh Fatemifar, Mohamad Zeina, R. Thomas Lumbers, Johanna Mielke, Simrat Gill, Dipak Kotecha, Daniel F. Freitag, Spiros Denaxas and Harry Hemingway

    Citation: BMC Medicine 2021 19:85

    Content type: Research article

    Published on:

  7. Gambiense human African trypanosomiasis (gHAT) has been brought under control recently with village-based active screening playing a major role in case reduction. In the approach to elimination, we investigate ho...

    Authors: Christopher N. Davis, Kat S. Rock, Marina Antillón, Erick Mwamba Miaka and Matt J. Keeling

    Citation: BMC Medicine 2021 19:86

    Content type: Research article

    Published on:

  8. Trans fatty acids (TFAs) have been hypothesised to influence breast cancer risk. However, relatively few prospective studies have examined this relationship, and well-powered analyses according to hormone recepto...

    Authors: Michèle Matta, Inge Huybrechts, Carine Biessy, Corinne Casagrande, Sahar Yammine, Agnès Fournier, Karina Standahl Olsen, Marco Lukic, Inger Torhild Gram, Eva Ardanaz, Maria-José Sánchez, Laure Dossus, Renée T. Fortner, Bernard Srour, Franziska Jannasch, Matthias B. Schulze…

    Citation: BMC Medicine 2021 19:81

    Content type: Research article

    Published on:

  9. Targeted therapy and immunotherapy put forward higher demands for accurate lung cancer classification, as well as benign versus malignant disease discrimination. Digital whole slide images (WSIs) witnessed the...

    Authors: Huan Yang, Lili Chen, Zhiqiang Cheng, Minglei Yang, Jianbo Wang, Chenghao Lin, Yuefeng Wang, Leilei Huang, Yangshan Chen, Sui Peng, Zunfu Ke and Weizhong Li

    Citation: BMC Medicine 2021 19:80

    Content type: Research article

    Published on:

  10. Whether earlier onset of puberty is associated with higher cardiovascular risk in early adulthood is not well understood. Our objective was to examine the association between puberty timing and markers of card...

    Authors: Gillian M. Maher, Lisa Ryan, Fergus P. McCarthy, Alun Hughes, Chloe Park, Abigail Fraser, Laura D. Howe, Patricia M. Kearney and Linda M. O’Keeffe

    Citation: BMC Medicine 2021 19:78

    Content type: Research article

    Published on:

  11. Accurate and robust pathological image analysis for colorectal cancer (CRC) diagnosis is time-consuming and knowledge-intensive, but is essential for CRC patients’ treatment. The current heavy workload of path...

    Authors: K. S. Wang, G. Yu, C. Xu, X. H. Meng, J. Zhou, C. Zheng, Z. Deng, L. Shang, R. Liu, S. Su, X. Zhou, Q. Li, J. Li, J. Wang, K. Ma, J. Qi…

    Citation: BMC Medicine 2021 19:76

    Content type: Research article

    Published on:

  12. Severe mental illness (SMI), comprising schizophrenia, bipolar disorder and major depression, is associated with higher myocardial infarction (MI) mortality but lower coronary revascularisation rates. Previous...

    Authors: Kelly Fleetwood, Sarah H. Wild, Daniel J. Smith, Stewart W. Mercer, Kirsty Licence, Cathie L. M. Sudlow and Caroline A. Jackson

    Citation: BMC Medicine 2021 19:67

    Content type: Research article

    Published on:

  13. There is a lack of national report of the labour neuraxial analgesia (NA) rates in China in recent years, especially after the national promotion policy. The adverse maternal and perinatal outcomes associated ...

    Authors: Yi Mu, Xiaodong Wang, Yanping Wang, Zheng Liu, Mingrong Li, Xiaohong Li, Qi Li, Jun Zhu, Juan Liang and Haidong Wang

    Citation: BMC Medicine 2021 19:74

    Content type: Research article

    Published on:

  14. Sleep traits are associated with cardiometabolic disease risk, with evidence from Mendelian randomization (MR) suggesting that insomnia symptoms and shorter sleep duration increase coronary artery disease risk...

    Authors: Maxime M. Bos, Neil J. Goulding, Matthew A. Lee, Amy Hofman, Mariska Bot, René Pool, Lisanne S. Vijfhuizen, Xiang Zhang, Chihua Li, Rima Mustafa, Matt J. Neville, Ruifang Li-Gao, Stella Trompet, Marian Beekman, Nienke R. Biermasz, Dorret I. Boomsma…

    Citation: BMC Medicine 2021 19:69

    Content type: Research article

    Published on:

  15. Beyond intakes of total energy and individual nutrient, eating patterns may influence health, and thereby the risk of adverse outcomes. How different diet measures relate to frailty—a general measure of increa...

    Authors: Kulapong Jayanama, Olga Theou, Judith Godin, Leah Cahill, Nitin Shivappa, James R. Hébert, Michael D. Wirth, Yong-Moon Park, Teresa T. Fung and Kenneth Rockwood

    Citation: BMC Medicine 2021 19:64

    Content type: Research article

    Published on:

  16. Previous studies showed that recovered coronavirus disease 2019 (COVID-19) patients can have a subsequent positive polymerase chain reaction (PCR) test for severe acute respiratory syndrome coronavirus 2 (SARS...

    Authors: Xiaomin Wu, Zengmiao Wang, Zhenyu He, Yapin Li, Yating Wu, Huaiji Wang, Yonghong Liu, Fanghua Hao and Huaiyu Tian

    Citation: BMC Medicine 2021 19:77

    Content type: Research article

    Published on:

  17. It is unclear whether insulin resistance (IR) contributes to excess mortality in patients with type 2 diabetes independent of diabetic kidney disease (DKD), which is strongly associated with IR and is a major ...

    Authors: Giuseppe Penno, Anna Solini, Emanuela Orsi, Enzo Bonora, Cecilia Fondelli, Roberto Trevisan, Monica Vedovato, Franco Cavalot, Gianpaolo Zerbini, Olga Lamacchia, Antonio Nicolucci and Giuseppe Pugliese

    Citation: BMC Medicine 2021 19:66

    Content type: Research article

    Published on:

  18. Reducing suicidal behaviour (SB) is a critical public health issue globally. The complex interplay of social determinants, service system factors, population demographics, and behavioural dynamics makes it ext...

    Authors: Jo-An Occhipinti, Adam Skinner, Frank Iorfino, Kenny Lawson, Julie Sturgess, Warren Burgess, Tracey Davenport, Danica Hudson and Ian Hickie

    Citation: BMC Medicine 2021 19:61

    Content type: Research article

    Published on:

  19. Cardiometabolic diseases (CMD) are the major cause of death worldwide and are associated with a lower quality of life and high healthcare costs. To prevent a further rise in CMD and related healthcare costs, e...

    Authors: Daphne M. Stol, Eelco A. B. Over, Ilse F. Badenbroek, Monika Hollander, Mark M. J. Nielen, Roderik A. Kraaijenhagen, François G. Schellevis, Niek J. de Wit and G. Ardine de Wit

    Citation: BMC Medicine 2021 19:57

    Content type: Research article

    Published on:

  20. Maternal folic acid (FA) supplementation before and in early pregnancy prevents neural tube defects (NTD), but it is uncertain whether continuing FA after the first trimester has benefits on offspring health. ...

    Authors: Aoife Caffrey, Helene McNulty, Mark Rollins, Girijesh Prasad, Pramod Gaur, Joel B. Talcott, Caroline Witton, Tony Cassidy, Barry Marshall, James Dornan, Adrian J. Moore, Mary Ward, J. J. Strain, Anne M. Molloy, Marian McLaughlin, Diane J. Lees-Murdock…

    Citation: BMC Medicine 2021 19:73

    Content type: Research article

    Published on:

  21. Testing plays a critical role in treatment and prevention responses to the COVID-19 pandemic. Compared to nucleic acid tests (NATs), antigen-detection rapid diagnostic tests (Ag-RDTs) can be more accessible, b...

    Authors: Saskia Ricks, Emily A. Kendall, David W. Dowdy, Jilian A. Sacks, Samuel G. Schumacher and Nimalan Arinaminpathy

    Citation: BMC Medicine 2021 19:75

    Content type: Research article

    Published on:

    The Commentary to this article has been published in BMC Medicine 2021 19:82

  22. Although a potential inverse association between vegetable intake and bladder cancer risk has been reported, epidemiological evidence is inconsistent. This research aimed to elucidate the association between v...

    Authors: Evan Yi-Wen Yu, Anke Wesselius, Siamak Mehrkanoon, Mieke Goosens, Maree Brinkman, Piet van den Brandt, Eric J. Grant, Emily White, Elisabete Weiderpass, Florence Le Calvez-Kelm, Marc J. Gunter, Inge Huybrechts, Elio Riboli, Anne Tjonneland, Giovanna Masala, Graham G. Giles…

    Citation: BMC Medicine 2021 19:56

    Content type: Research article

    Published on:

  23. Currently, many patients suffering from dementia do not have a diagnosis when admitted to geriatric hospitals. This is the case despite an increased risk of complications affecting the length of stay and outco...

    Authors: Wolfgang Trapp, Susanne Röder, Andreas Heid, Pia Billman, Susanne Daiber and Göran Hajak

    Citation: BMC Medicine 2021 19:65

    Content type: Research article

    Published on:

  24. Artificial intelligence (AI) in diagnostic radiology is undergoing rapid development. Its potential utility to improve diagnostic performance for cardiopulmonary events is widely recognized, but the accuracy a...

    Authors: Jordan Chamberlin, Madison R. Kocher, Jeffrey Waltz, Madalyn Snoddy, Natalie F. C. Stringer, Joseph Stephenson, Pooyan Sahbaee, Puneet Sharma, Saikiran Rapaka, U. Joseph Schoepf, Andres F. Abadia, Jonathan Sperl, Phillip Hoelzer, Megan Mercer, Nayana Somayaji, Gilberto Aquino…

    Citation: BMC Medicine 2021 19:55

    Content type: Research article

    Published on:

  25. The World Health Assembly has adopted a global strategy to eliminate cervical cancer. However, neither the optimal pathway nor the corresponding economic and health benefits have been evaluated. We take China ...

    Authors: Changfa Xia, Xiaoqian Xu, Xuelian Zhao, Shangying Hu, Youlin Qiao, Yong Zhang, Raymond Hutubessy, Partha Basu, Nathalie Broutet, Mark Jit and Fanghui Zhao

    Citation: BMC Medicine 2021 19:62

    Content type: Research article

    Published on:

  26. There is limited prospective evidence on the association between meat consumption and many common, non-cancerous health outcomes. We examined associations of meat intake with risk of 25 common conditions (othe...

    Authors: Keren Papier, Georgina K. Fensom, Anika Knuppel, Paul N. Appleby, Tammy Y. N. Tong, Julie A. Schmidt, Ruth C. Travis, Timothy J. Key and Aurora Perez-Cornago

    Citation: BMC Medicine 2021 19:53

    Content type: Research article

    Published on:

  27. Despite recent advances through the development pipeline, how novel tuberculosis (TB) vaccines might affect rifampicin-resistant and multidrug-resistant tuberculosis (RR/MDR-TB) is unknown. We investigated the...

    Authors: Chathika K Weerasuriya, Rebecca C Harris, C Finn McQuaid, Fiammetta Bozzani, Yunzhou Ruan, Renzhong Li, Tao Li, Kirankumar Rade, Raghuram Rao, Ann M Ginsberg, Gabriela B Gomez and Richard G White

    Citation: BMC Medicine 2021 19:60

    Content type: Research article

    Published on:

  28. Long noncoding (lnc)RNAs and glycolysis are both recognized as key regulators of cancers. Some lncRNAs are also reportedly involved in regulating glycolysis metabolism. However, glycolysis-associated lncRNA si...

    Authors: Kuo-Hao Ho, Tzu-Wen Huang, Chwen-Ming Shih, Yi-Ting Lee, Ann-Jeng Liu, Peng-Hsu Chen and Ku-Chung Chen

    Citation: BMC Medicine 2021 19:59

    Content type: Research article

    Published on:

  29. Males experience higher rates of coronary heart disease (CHD) than females, but the circulating traits underpinning this difference are poorly understood. We examined sex differences in systemic metabolites me...

    Authors: Joshua A. Bell, Diana L. Santos Ferreira, Abigail Fraser, Ana Luiza G. Soares, Laura D. Howe, Deborah A. Lawlor, David Carslake, George Davey Smith and Linda M. O’Keeffe

    Citation: BMC Medicine 2021 19:58

    Content type: Research article

    Published on:

  30. Following the initial identification of the 2019 coronavirus disease (covid-19), the subsequent months saw substantial increases in published biomedical research. Concerns have been raised in both scientific a...

    Authors: Terence J. Quinn, Jennifer K. Burton, Ben Carter, Nicola Cooper, Kerry Dwan, Ryan Field, Suzanne C. Freeman, Claudia Geue, Ping-Hsuan Hsieh, Kris McGill, Clareece R. Nevill, Dikshyanta Rana, Alex Sutton, Martin Taylor Rowan and Yiqiao Xin

    Citation: BMC Medicine 2021 19:46

    Content type: Research article

    Published on:

  31. The objective of this study was to investigate the relation of severe COVID-19 to prior drug prescribing.

    Authors: Paul M. McKeigue, Sharon Kennedy, Amanda Weir, Jen Bishop, Stuart J. McGurnaghan, David McAllister, Chris Robertson, Rachael Wood, Nazir Lone, Janet Murray, Thomas M. Caparrotta, Alison Smith-Palmer, David Goldberg, Jim McMenamin, Bruce Guthrie, Sharon Hutchinson…

    Citation: BMC Medicine 2021 19:51

    Content type: Research article

    Published on:

  32. Mounting evidence suggests that maternal diet influences pregnancy and birth outcomes, but its contribution to the global epidemic of childhood obesity has not as yet been definitively characterized. We invest...

    Authors: Ling-Wei Chen, Adrien M. Aubert, Nitin Shivappa, Jonathan Y. Bernard, Sara M. Mensink-Bout, Aisling A. Geraghty, John Mehegan, Matthew Suderman, Kinga Polanska, Wojciech Hanke, Agnieszka Jankowska, Caroline L. Relton, Sarah R. Crozier, Nicholas C. Harvey, Cyrus Cooper, Mark Hanson…

    Citation: BMC Medicine 2021 19:33

    Content type: Research article

    Published on:

    The Commentary to this article has been published in BMC Medicine 2021 19:68

  33. England’s COVID-19 response transitioned from a national lockdown to localised interventions. In response to rising cases, these were supplemented by national restrictions on contacts (the Rule of Six), then 1...

    Authors: Christopher I. Jarvis, Amy Gimma, Kevin van Zandvoort, Kerry L. M. Wong and W. John Edmunds

    Citation: BMC Medicine 2021 19:52

    Content type: Research article

    Published on:

  34. The micronutrient iodine is essential for a healthy intrauterine environment and is required for optimal fetal growth and neurodevelopment. Evidence linking urinary iodine concentrations, which mainly reflects...

    Authors: Kristof Y. Neven, Bianca Cox, Charlotte Cosemans, Wilfried Gyselaers, Joris Penders, Michelle Plusquin, Harry A. Roels, Karen Vrijens, Ann Ruttens and Tim S. Nawrot

    Citation: BMC Medicine 2021 19:47

    Content type: Research article

    Published on:

  35. The C2HEST score has been validated for predicting AF in the general population or post-stroke patients. We aimed to assess whether this risk score could predict incident AF and other clinical outcomes in heart f...

    Authors: Weihao Liang, Yuzhong Wu, Ruicong Xue, Zexuan Wu, Dexi Wu, Jiangui He, Yugang Dong, Gregory Y. H. Lip, Wengen Zhu and Chen Liu

    Citation: BMC Medicine 2021 19:44

    Content type: Research article

    Published on:

  36. Following implementation of strong containment measures, several countries and regions have low detectable community transmission of COVID-19. We developed an efficient, rapid, and scalable surveillance strate...

    Authors: K. Lokuge, E. Banks, S. Davis, L. Roberts, T. Street, D. O’Donovan, G. Caleo and K. Glass

    Citation: BMC Medicine 2021 19:50

    Content type: Research article

    Published on:

  37. Serum transferrin levels represent an independent predictor of mortality in patients with liver failure. Hepatocyte nuclear factor 4 alpha (HNF4α) is a master regulator of hepatocyte functions. The aim of this...

    Authors: Nurdan Guldiken, Josepmaria Argemi, Berivan Gurbuz, Stephen R. Atkinson, Martin Oliverius, Petr Fila, Karim Hamesch, Tony Bruns, Joaquín Cabezas, Juan J. Lozano, Jelena Mann, Sheng Cao, Philippe Mathurin, Vijay H. Shah, Christian Trautwein, Mark R. Thursz…

    Citation: BMC Medicine 2021 19:39

    Content type: Research article

    Published on:

  38. Despite the growing burden of heart failure (HF), there have been no recommendations for use of any of the primary prevention models in the existing guidelines. HF was also not included as an outcome in the Am...

    Authors: Banafsheh Arshi, Jan C. van den Berge, Bart van Dijk, Jaap W. Deckers, M. Arfan Ikram and Maryam Kavousi

    Citation: BMC Medicine 2021 19:43

    Content type: Research article

    Published on:

  39. Characteristics of the built environment, such as neighbourhood fast-food outlet exposure, are increasingly recognised as risk factors for unhealthy diet and obesity. Obesity also has a genetic component, with...

    Authors: Thomas Burgoine, Pablo Monsivais, Stephen J. Sharp, Nita G. Forouhi and Nicholas J. Wareham

    Citation: BMC Medicine 2021 19:49

    Content type: Research article

    Published on:

  40. Neurofilament light chain (NfL) is a cytoskeletal protein component whose release into blood is indicative of neuronal damage. Tau is a microtubule-associated protein in neurons and strongly associated with ov...

    Authors: Nicole Rübsamen, Aleksandra Maceski, David Leppert, Pascal Benkert, Jens Kuhle, Heinz Wiendl, Annette Peters, André Karch and Klaus Berger

    Citation: BMC Medicine 2021 19:38

    Content type: Research article

    Published on:

  • Editorial Team
  • Editorial Board
  • Call for papers
  • Editor’s choice
  • Sign up for article alerts and news from this journal
  • Contact
  • Annual Journal Metrics

  • Announcements

    medRxiv transfers

    BMC Medicine is happy to consider manuscripts that have been, or will be, posted on a preprint server. Authors are able to submit their manuscripts directly from medRxiv, without having to re-upload files.

    Portable peer review

    To reduce time spent on serial submissions and iterative reviewing, BMC Medicine offers to consider manuscripts on the basis of reviews received at other journals. We also support transfers of reviews obtained at BMC Medicine to other journals, including those outside of BMC and Springer Nature. Learn more from our portable reviews page.

    COVID-19 and impact on peer review

    As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.

    Registered reports

    BMC Medicine is accepting Registered Reports. Find out more about this innovative format in our Submission Guidelines.

\