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  1. Smokeless tobacco (ST) is consumed by more than 300 million people worldwide. The distribution, determinants and health risks of ST differ from that of smoking; hence, there is a need to highlight its distinct...

    Authors: Kamran Siddiqi, Scheherazade Husain, Aishwarya Vidyasagaran, Anne Readshaw, Masuma Pervin Mishu and Aziz Sheikh

    Citation: BMC Medicine 2020 18:222

    Content type: Research article

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  2. Severe iodine deficiency impacts fertility and reproductive outcomes. The potential effects of mild-to-moderate iodine deficiency are not well known. The aim of this study was to examine whether iodine intake ...

    Authors: Marianne Hope Abel, Ida Henriette Caspersen, Verena Sengpiel, Bo Jacobsson, Helle Margrete Meltzer, Per Magnus, Jan Alexander and Anne Lise Brantsæter

    Citation: BMC Medicine 2020 18:211

    Content type: Research article

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  3. Intermittent preventive treatment of malaria during pregnancy (IPTp) with dihydroartemisinin-piperaquine (DP) significantly reduces the burden of malaria during pregnancy compared to sulfadoxine-pyrimethamine ...

    Authors: Abel Kakuru, Prasanna Jagannathan, Richard Kajubi, Teddy Ochieng, Harriet Ochokoru, Miriam Nakalembe, Tamara D. Clark, Theodore Ruel, Sarah G. Staedke, Daniel Chandramohan, Diane V. Havlir, Moses R. Kamya and Grant Dorsey

    Citation: BMC Medicine 2020 18:207

    Content type: Research article

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  4. The spatial spread of many mosquito-borne diseases occurs by focal spread at the scale of a few hundred meters and over longer distances due to human mobility. The relative contributions of different spatial s...

    Authors: Giorgio Guzzetta, Francesco Vairo, Alessia Mammone, Simone Lanini, Piero Poletti, Mattia Manica, Roberto Rosa, Beniamino Caputo, Angelo Solimini, Alessandra Della Torre, Paola Scognamiglio, Alimuddin Zumla, Giuseppe Ippolito and Stefano Merler

    Citation: BMC Medicine 2020 18:226

    Content type: Research article

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  5. COVID-19 is an extremely severe infectious disease. However, few studies have focused on the epidemiological and clinical characteristics of pediatric COVID-19. This study conducted a retrospective review of t...

    Authors: Cheng-Xian Guo, Li He, Ji-Ye Yin, Xiang-Guang Meng, Wei Tan, Guo-Ping Yang, Tao Bo, Jun-Ping Liu, Xin-Jian Lin and Xiang Chen

    Citation: BMC Medicine 2020 18:250

    Content type: Research article

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  6. Total hip replacement (THR) is clinically and cost-effective. The surgical approach employed influences the outcome; however, there is little generalisable and robust evidence to guide practice.

    Authors: Ashley W. Blom, Linda P. Hunt, Gulraj S. Matharu, Michael R. Reed and Michael R. Whitehouse

    Citation: BMC Medicine 2020 18:242

    Content type: Research article

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  7. Dementia shows sex difference in its epidemiology. Childbirth, a distinctive experience of women, is associated with the risk for various diseases. However, its association with the risk of dementia in women h...

    Authors: Jong Bin Bae, Darren M. Lipnicki, Ji Won Han, Perminder S. Sachdev, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu, Jong Chul Youn, Dong Young Lee, Dong Woo Lee, Seok Bum Lee…

    Citation: BMC Medicine 2020 18:210

    Content type: Research article

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  8. In recent years, there have been adverse trends in premature cardiovascular disease (CVD) mortality rates (35–74 years) in the USA and Australia. Following long-term declines, rates in the USA are now increasi...

    Authors: Tim Adair and Alan D. Lopez

    Citation: BMC Medicine 2020 18:199

    Content type: Research article

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  9. Circulating cell-free DNA (cfDNA) methylation has been demonstrated to be a promising approach for non-invasive cancer diagnosis. However, the high cost of whole genome bisulfite sequencing (WGBS) hinders the ...

    Authors: Haikun Zhang, Peiling Dong, Shicheng Guo, Chengcheng Tao, Wei Chen, Wenmin Zhao, Jiakang Wang, Ramsey Cheung, Augusto Villanueva, Jian Fan, Huiguo Ding, Steven J. Schrodi, Dake Zhang and Changqing Zeng

    Citation: BMC Medicine 2020 18:200

    Content type: Research article

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  10. Citizens affected by substance use disorders are high-risk populations for both SARS-CoV-2 infection and COVID-19-related mortality. Relevant vulnerabilities to COVID-19 in people who suffer substance use diso...

    Authors: Hugo López-Pelayo, Henri-Jean Aubin, Colin Drummond, Geert Dom, Francisco Pascual, Jürgen Rehm, Richard Saitz, Emanuele Scafato and Antoni Gual

    Citation: BMC Medicine 2020 18:241

    Content type: Debate

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  11. Zika virus (ZIKV) infection is a global health problem, and its complications, including congenital Zika syndrome and Guillain-Barré syndrome, constitute a continued threat to humans. Unfortunately, effective ...

    Authors: Jie Yuan, Jianchen Yu, Yun Huang, Zhenjian He, Jia Luo, Yun Wu, Yingchun Zheng, Jueheng Wu, Xun Zhu, Haihe Wang and Mengfeng Li

    Citation: BMC Medicine 2020 18:204

    Content type: Research article

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  12. More than half of the global population is under strict forms of social distancing. Estimating the expected impact of lockdown and exit strategies is critical to inform decision makers on the management of the...

    Authors: Laura Di Domenico, Giulia Pullano, Chiara E. Sabbatini, Pierre-Yves Boëlle and Vittoria Colizza

    Citation: BMC Medicine 2020 18:240

    Content type: Research article

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  13. The COVID-19 pandemic has resulted in millions of infections, hundreds of thousands of deaths and major societal disruption due to lockdowns and other restrictions introduced to limit disease spread. Relativel...

    Authors: Stephen J. Rogerson, James G. Beeson, Moses Laman, Jeanne Rini Poespoprodjo, Timothy William, Julie A. Simpson and Ric N. Price

    Citation: BMC Medicine 2020 18:239

    Content type: Opinion

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  14. Deciding whether to discontinue antibiotics at early review is a cornerstone of hospital antimicrobial stewardship practice worldwide. In England, this approach is described in government guidance (‘Start Smar...

    Authors: Laurence S. J. Roope, James Buchanan, Liz Morrell, Koen B. Pouwels, Katy Sivyer, Fiona Mowbray, Lucy Abel, Elizabeth L. A. Cross, Lucy Yardley, Tim Peto, A. Sarah Walker, Martin J. Llewelyn and Sarah Wordsworth

    Citation: BMC Medicine 2020 18:196

    Content type: Research article

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  15. The safety of restarting angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARB) after acute kidney injury (AKI) is unclear. There is concern that previous users do not restar...

    Authors: Patrick Bidulka, Edouard L. Fu, Clémence Leyrat, Fotini Kalogirou, Katherine S. L. McAllister, Edward J. Kingdon, Kathryn E. Mansfield, Masao Iwagami, Liam Smeeth, Catherine M. Clase, Krishnan Bhaskaran, Merel van Diepen, Juan-Jesus Carrero, Dorothea Nitsch and Laurie A. Tomlinson

    Citation: BMC Medicine 2020 18:195

    Content type: Research article

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  16. Access to oxytocin for prevention of postpartum haemorrhage (PPH) in resource-poor settings is limited by the requirement for a consistent cold chain and for a skilled attendant to administer the injection. To...

    Authors: Natalie Carvalho, Mohammad Enamul Hoque, Victoria L. Oliver, Abbey Byrne, Michelle Kermode, Pete Lambert, Michelle P. McIntosh and Alison Morgan

    Citation: BMC Medicine 2020 18:201

    Content type: Research article

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  17. Cardiovascular disease is responsible for 31% of all global deaths. Primary prevention strategies are needed to improve longer-term adherence to statins and healthy lifestyle behaviours to reduce risk in peopl...

    Authors: Jo L. Byrne, Helen M. Dallosso, Stephen Rogers, Laura J. Gray, Ghazala Waheed, Prashanth Patel, Pankaj Gupta, Yvonne Doherty, Melanie J. Davies and Kamlesh Khunti

    Citation: BMC Medicine 2020 18:198

    Content type: Research article

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  18. The province of Ontario, Canada, has instituted indefinite school closures (SC) as well as other social distancing measures to mitigate the impact of the novel coronavirus disease 2019 (COVID-19) pandemic. We ...

    Authors: Elaheh Abdollahi, Margaret Haworth-Brockman, Yoav Keynan, Joanne M. Langley and Seyed M. Moghadas

    Citation: BMC Medicine 2020 18:230

    Content type: Research article

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  19. Maternal weight variables are important predictors of postpartum depression (PPD). While preliminary evidence points to an association between pre-pregnancy obesity and PPD, the role of excessive gestational w...

    Authors: Hamimatunnisa Johar, Julia Hoffmann, Julia Günther, Seryan Atasoy, Lynne Stecher, Monika Spies, Hans Hauner and Karl-Heinz Ladwig

    Citation: BMC Medicine 2020 18:227

    Content type: Research article

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  20. Adolescent depression is a global mental health concern. Identification and effective prevention in an early stage are necessary. The present randomized, controlled trial aimed to examine the effectiveness of ...

    Authors: Karlijn W. J. de Jonge-Heesen, Sanne P. A. Rasing, Ad A. Vermulst, Ron H. J. Scholte, Kim M. van Ettekoven, Rutger C. M. E. Engels and Daan H. M. Creemers

    Citation: BMC Medicine 2020 18:188

    Content type: Research article

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  21. Prostate cancer is the second most frequently diagnosed cancer in men. Metabolomics can potentially provide new insights into the aetiology of prostate cancer by identifying new metabolic risk factors. This st...

    Authors: Hanna E. Röhnisch, Cecilie Kyrø, Anja Olsen, Elin Thysell, Göran Hallmans and Ali A. Moazzami

    Citation: BMC Medicine 2020 18:187

    Content type: Research article

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  22. Involving adults lacking capacity (ALC) in research on end of life care (EoLC) or serious illness is important, but often omitted. We aimed to develop evidence-based guidance on how best to include individuals...

    Authors: C. J. Evans, E. Yorganci, P. Lewis, J. Koffman, K. Stone, I. Tunnard, B. Wee, W. Bernal, M. Hotopf and I. J. Higginson

    Citation: BMC Medicine 2020 18:221

    Content type: Research article

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  23. There is an urgent need to develop biomarkers that stratify risk of bacterial infection in order to support antimicrobial stewardship in emergency hospital admissions.

    Authors: Dayle Sampson, Thomas D. Yager, Brian Fox, Laura Shallcross, Leo McHugh, Therese Seldon, Antony Rapisarda, Richard B. Brandon, Krupa Navalkar, Nandi Simpson, Sian Stafford, Eliza Gil, Cristina Venturini, Evi Tsaliki, Jennifer Roe, Benjamin Chain…

    Citation: BMC Medicine 2020 18:185

    Content type: Research article

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  24. The prevention of tuberculosis (TB) is key for accelerating current, slow declines in TB burden. The 2018 World Health Organization (WHO) guidelines on eligibility for preventive therapy to treat latent TB inf...

    Authors: Sandip Mandal, Vineet Bhatia, Mukta Sharma, Partha Pratim Mandal and Nimalan Arinaminpathy

    Citation: BMC Medicine 2020 18:163

    Content type: Research article

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  25. Non-typhoidal Salmonella (NTS) are a frequent cause of invasive infections in sub-Saharan Africa. They are frequently multidrug resistant (co-resistant to ampicillin, trimethoprim-sulfamethoxazole, and chloramphe...

    Authors: Bieke Tack, Jolien Vanaenrode, Jan Y. Verbakel, Jaan Toelen and Jan Jacobs

    Citation: BMC Medicine 2020 18:212

    Content type: Research article

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  26. The prevalence of excess adiposity, as measured by elevated body mass index (BMI) and waist-hip ratio (WHR), is increasing in sub-Saharan African (SSA) populations. This could add a considerable burden of card...

    Authors: Ana Luiza G. Soares, Louis Banda, Alemayehu Amberbir, Shabbar Jaffar, Crispin Musicha, Alison J. Price, Amelia C. Crampin, Moffat J. Nyirenda and Deborah A. Lawlor

    Citation: BMC Medicine 2020 18:181

    Content type: Research article

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  27. In women of reproductive age, polycystic ovary syndrome (PCOS) constitutes the most frequent endocrine disorder. Women with PCOS are considered to typically belong to an age and sex group which is at lower ris...

    Authors: Ioannis Kyrou, Emmanouil Karteris, Tim Robbins, Kamaljit Chatha, Fotios Drenos and Harpal S. Randeva

    Citation: BMC Medicine 2020 18:220

    Content type: Opinion

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  28. School closures have been enacted as a measure of mitigation during the ongoing coronavirus disease 2019 (COVID-19) pandemic. It has been shown that school closures could cause absenteeism among healthcare wor...

    Authors: Elizabeth T. Chin, Benjamin Q. Huynh, Nathan C. Lo, Trevor Hastie and Sanjay Basu

    Citation: BMC Medicine 2020 18:218

    Content type: Research article

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  29. Since the first cluster of cases was identified in Wuhan City, China, in December 2019, coronavirus disease 2019 (COVID-19) rapidly spreads globally. Scientists have made strides in estimating key transmission...

    Authors: Kenji Mizumoto, Katsushi Kagaya and Gerardo Chowell

    Citation: BMC Medicine 2020 18:217

    Content type: Research article

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  30. Coronavirus Disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has now been confirmed worldwide. Yet, COVID-19 is strangely and tragically selective. Morbidity...

    Authors: Yuan Hou, Junfei Zhao, William Martin, Asha Kallianpur, Mina K. Chung, Lara Jehi, Nima Sharifi, Serpil Erzurum, Charis Eng and Feixiong Cheng

    Citation: BMC Medicine 2020 18:216

    Content type: Correspondence

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  31. The novel coronavirus pandemic calls for a rapid adaptation of conventional medical practices to meet the evolving needs of such vulnerable patients. People with coronavirus disease (COVID-19) may frequently r...

    Authors: Giovanni Ostuzzi, Davide Papola, Chiara Gastaldon, Georgios Schoretsanitis, Federico Bertolini, Francesco Amaddeo, Alessandro Cuomo, Robin Emsley, Andrea Fagiolini, Giuseppe Imperadore, Taishiro Kishimoto, Giulia Michencigh, Michela Nosé, Marianna Purgato, Dursun Serdar, Brendon Stubbs…

    Citation: BMC Medicine 2020 18:215

    Content type: Research article

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  32. Hitherto only studies with selected populations have found an increased all-cause mortality of some selected opioids compared to selected non-opioids for chronic non-cancer pain (CNCP). We have examined the al...

    Authors: Winfried Häuser, Tino Schubert, Tobias Vogelmann, Christoph Maier, Mary-Ann Fitzcharles and Thomas Tölle

    Citation: BMC Medicine 2020 18:162

    Content type: Research article

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  33. Acute kidney injury (AKI) has become a global health issue. Little is known about the disease burden in Laos. We aimed to evaluate the burden and outcomes of AKI as well as assess the availability of AKI treat...

    Authors: Noot Sengthavisouk, Nuttha Lumlertgul, Chanmaly Keomany, Phonepadith Banouvong, Phetvilay Senavong, Sidavone Sayyaphet, Sakountala Binbundith, Win Kulvichit, Sadudee Peerapornratana, Kearkiat Praditpornsilpa, Kriang Tungsanga, Somchai Eiam-Ong and Nattachai Srisawat

    Citation: BMC Medicine 2020 18:180

    Content type: Research article

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  34. In patients with iron deficiency anemia, ferric carboxymaltose (FCM) and ferric derisomaltose (FDI) allow high-dose iron repletion. While FCM is reported to induce hypophosphatemia, the frequency of hypophosph...

    Authors: I. E. Emrich, F. Lizzi, J. D. Siegel, S. Seiler-Mussler, C. Ukena, D. Kaddu-Mulindwa, R. D’Amelio, S. Wagenpfeil, V. M. Brandenburg, M. Böhm, D. Fliser and G. H. Heine

    Citation: BMC Medicine 2020 18:178

    Content type: Research article

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  35. A connection between amyotrophic lateral sclerosis (ALS) and altered gut microbiota composition has previously been reported in animal models. This work is the first prospective longitudinal study addressing t...

    Authors: Diana Di Gioia, Nicole Bozzi Cionci, Loredana Baffoni, Angela Amoruso, Marco Pane, Luca Mogna, Francesca Gaggìa, Maria Ausiliatrice Lucenti, Enrica Bersano, Roberto Cantello, Fabiola De Marchi and Letizia Mazzini

    Citation: BMC Medicine 2020 18:153

    Content type: Research article

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  36. The early life risk factors of childhood obesity among preterm infants are unclear and little is known about the influence of the feeding practices. We aimed to identify early life risk factors for childhood o...

    Authors: Yuanqing Fu, Wanglong Gou, Wensheng Hu, Yingying Mao, Yunyi Tian, Xinxiu Liang, Yuhong Guan, Tao Huang, Kelei Li, Xiaofei Guo, Huijuan Liu, Duo Li and Ju-Sheng Zheng

    Citation: BMC Medicine 2020 18:184

    Content type: Research article

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  37. Release of virus-blocking Wolbachia-infected mosquitoes is an emerging disease control strategy that aims to control dengue and other arboviral infections. Early entomological data and modelling analyses have sug...

    Authors: Oliver J. Brady, Dinar D. Kharisma, Nandyan N. Wilastonegoro, Kathleen M. O’Reilly, Emilie Hendrickx, Leonardo S. Bastos, Laith Yakob and Donald S. Shepard

    Citation: BMC Medicine 2020 18:186

    Content type: Research article

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  38. Rapid development of an effective vaccine for SARSCoV2 is a global priority. A controlled human infection model (CHIM) would accelerate the efficacy assessment of candidate vaccines. This strategy would requir...

    Authors: D. Gbesemete, M. Barker, W. T. Lawrence, D. Watson, H. de Graaf and R. C. Read

    Citation: BMC Medicine 2020 18:209

    Content type: Correspondence

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  39. HIV remains the largest cause of disease burden among men and women of reproductive age in sub-Saharan Africa. Voluntary medical male circumcision (VMMC) reduces the risk of female-to-male transmission of HIV ...

    Authors: Michael A. Cork, Kate F. Wilson, Samantha Perkins, Michael L. Collison, Aniruddha Deshpande, Jeffrey W. Eaton, Lucas Earl, Emily Haeuser, Jessica E. Justman, Damaris K. Kinyoki, Benjamin K. Mayala, Jonathan F. Mosser, Christopher J. L. Murray, John N. Nkengasong, Peter Piot, Benn Sartorius…

    Citation: BMC Medicine 2020 18:189

    Content type: Research article

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  40. Children with cancer experience impaired cardiorespiratory fitness and physical function during and after treatment restricting their possibilities to engage in social activities including sport, leisure activ...

    Authors: Martin Kaj Fridh Nielsen, Jesper Frank Christensen, Thomas Leth Frandsen, Troels Thorsteinsson, Lars Bo Andersen, Karl Bang Christensen, Peder Skov Wehner, Henrik Hasle, Lis Ørgaard Adamsen, Kjeld Schmiegelow and Hanne Bækgaard Larsen

    Citation: BMC Medicine 2020 18:175

    Content type: Research article

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  41. Death registration completeness has never been assessed at the county level in China. Such analyses would provide critical intelligence to monitor the performance of the vital registration system and yield adj...

    Authors: Xinying Zeng, Tim Adair, Lijun Wang, Peng Yin, Jinlei Qi, Yunning Liu, Jiangmei Liu, Alan D. Lopez and Maigeng Zhou

    Citation: BMC Medicine 2020 18:176

    Content type: Research article

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  42. Infection with cytomegalovirus (CMV) is highly prevalent worldwide and can cause severe disease in immunocompromised persons and congenitally infected infants. The disease burden caused by congenital CMV infec...

    Authors: Ganna Rozhnova, Mirjam E. Kretzschmar, Fiona van der Klis, Debbie van Baarle, Marjolein Korndewal, Ann C. Vossen and Michiel van Boven

    Citation: BMC Medicine 2020 18:174

    Content type: Research Article

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  43. Few studies of biomarkers as predictors of outcome in infection have been performed in tropical, low- and middle-income countries where the burden of sepsis is highest. We evaluated whether selected biomarkers...

    Authors: Shelton W. Wright, Lara Lovelace-Macon, Viriya Hantrakun, Kristina E. Rudd, Prapit Teparrukkul, Susanna Kosamo, W. Conrad Liles, Direk Limmathurotsakul and T. Eoin West

    Citation: BMC Medicine 2020 18:159

    Content type: Research article

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