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  1. Currently, many patients suffering from dementia do not have a diagnosis when admitted to geriatric hospitals. This is the case despite an increased risk of complications affecting the length of stay and outco...

    Authors: Wolfgang Trapp, Susanne Röder, Andreas Heid, Pia Billman, Susanne Daiber and Göran Hajak

    Citation: BMC Medicine 2021 19:65

    Content type: Research article

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  2. Artificial intelligence (AI) in diagnostic radiology is undergoing rapid development. Its potential utility to improve diagnostic performance for cardiopulmonary events is widely recognized, but the accuracy a...

    Authors: Jordan Chamberlin, Madison R. Kocher, Jeffrey Waltz, Madalyn Snoddy, Natalie F. C. Stringer, Joseph Stephenson, Pooyan Sahbaee, Puneet Sharma, Saikiran Rapaka, U. Joseph Schoepf, Andres F. Abadia, Jonathan Sperl, Phillip Hoelzer, Megan Mercer, Nayana Somayaji, Gilberto Aquino…

    Citation: BMC Medicine 2021 19:55

    Content type: Research article

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  3. The World Health Assembly has adopted a global strategy to eliminate cervical cancer. However, neither the optimal pathway nor the corresponding economic and health benefits have been evaluated. We take China ...

    Authors: Changfa Xia, Xiaoqian Xu, Xuelian Zhao, Shangying Hu, Youlin Qiao, Yong Zhang, Raymond Hutubessy, Partha Basu, Nathalie Broutet, Mark Jit and Fanghui Zhao

    Citation: BMC Medicine 2021 19:62

    Content type: Research article

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  4. There is limited prospective evidence on the association between meat consumption and many common, non-cancerous health outcomes. We examined associations of meat intake with risk of 25 common conditions (othe...

    Authors: Keren Papier, Georgina K. Fensom, Anika Knuppel, Paul N. Appleby, Tammy Y. N. Tong, Julie A. Schmidt, Ruth C. Travis, Timothy J. Key and Aurora Perez-Cornago

    Citation: BMC Medicine 2021 19:53

    Content type: Research article

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  5. Despite recent advances through the development pipeline, how novel tuberculosis (TB) vaccines might affect rifampicin-resistant and multidrug-resistant tuberculosis (RR/MDR-TB) is unknown. We investigated the...

    Authors: Chathika K Weerasuriya, Rebecca C Harris, C Finn McQuaid, Fiammetta Bozzani, Yunzhou Ruan, Renzhong Li, Tao Li, Kirankumar Rade, Raghuram Rao, Ann M Ginsberg, Gabriela B Gomez and Richard G White

    Citation: BMC Medicine 2021 19:60

    Content type: Research article

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  6. Long noncoding (lnc)RNAs and glycolysis are both recognized as key regulators of cancers. Some lncRNAs are also reportedly involved in regulating glycolysis metabolism. However, glycolysis-associated lncRNA si...

    Authors: Kuo-Hao Ho, Tzu-Wen Huang, Chwen-Ming Shih, Yi-Ting Lee, Ann-Jeng Liu, Peng-Hsu Chen and Ku-Chung Chen

    Citation: BMC Medicine 2021 19:59

    Content type: Research article

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  7. Males experience higher rates of coronary heart disease (CHD) than females, but the circulating traits underpinning this difference are poorly understood. We examined sex differences in systemic metabolites me...

    Authors: Joshua A. Bell, Diana L. Santos Ferreira, Abigail Fraser, Ana Luiza G. Soares, Laura D. Howe, Deborah A. Lawlor, David Carslake, George Davey Smith and Linda M. O’Keeffe

    Citation: BMC Medicine 2021 19:58

    Content type: Research article

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  8. Following the initial identification of the 2019 coronavirus disease (covid-19), the subsequent months saw substantial increases in published biomedical research. Concerns have been raised in both scientific a...

    Authors: Terence J. Quinn, Jennifer K. Burton, Ben Carter, Nicola Cooper, Kerry Dwan, Ryan Field, Suzanne C. Freeman, Claudia Geue, Ping-Hsuan Hsieh, Kris McGill, Clareece R. Nevill, Dikshyanta Rana, Alex Sutton, Martin Taylor Rowan and Yiqiao Xin

    Citation: BMC Medicine 2021 19:46

    Content type: Research article

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  9. The objective of this study was to investigate the relation of severe COVID-19 to prior drug prescribing.

    Authors: Paul M. McKeigue, Sharon Kennedy, Amanda Weir, Jen Bishop, Stuart J. McGurnaghan, David McAllister, Chris Robertson, Rachael Wood, Nazir Lone, Janet Murray, Thomas M. Caparrotta, Alison Smith-Palmer, David Goldberg, Jim McMenamin, Bruce Guthrie, Sharon Hutchinson…

    Citation: BMC Medicine 2021 19:51

    Content type: Research article

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  10. Mounting evidence suggests that maternal diet influences pregnancy and birth outcomes, but its contribution to the global epidemic of childhood obesity has not as yet been definitively characterized. We invest...

    Authors: Ling-Wei Chen, Adrien M. Aubert, Nitin Shivappa, Jonathan Y. Bernard, Sara M. Mensink-Bout, Aisling A. Geraghty, John Mehegan, Matthew Suderman, Kinga Polanska, Wojciech Hanke, Agnieszka Jankowska, Caroline L. Relton, Sarah R. Crozier, Nicholas C. Harvey, Cyrus Cooper, Mark Hanson…

    Citation: BMC Medicine 2021 19:33

    Content type: Research article

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    A Letter has been published.

  11. England’s COVID-19 response transitioned from a national lockdown to localised interventions. In response to rising cases, these were supplemented by national restrictions on contacts (the Rule of Six), then 1...

    Authors: Christopher I. Jarvis, Amy Gimma, Kevin van Zandvoort, Kerry L. M. Wong and W. John Edmunds

    Citation: BMC Medicine 2021 19:52

    Content type: Research article

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  12. The micronutrient iodine is essential for a healthy intrauterine environment and is required for optimal fetal growth and neurodevelopment. Evidence linking urinary iodine concentrations, which mainly reflects...

    Authors: Kristof Y. Neven, Bianca Cox, Charlotte Cosemans, Wilfried Gyselaers, Joris Penders, Michelle Plusquin, Harry A. Roels, Karen Vrijens, Ann Ruttens and Tim S. Nawrot

    Citation: BMC Medicine 2021 19:47

    Content type: Research article

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  13. The C2HEST score has been validated for predicting AF in the general population or post-stroke patients. We aimed to assess whether this risk score could predict incident AF and other clinical outcomes in heart f...

    Authors: Weihao Liang, Yuzhong Wu, Ruicong Xue, Zexuan Wu, Dexi Wu, Jiangui He, Yugang Dong, Gregory Y. H. Lip, Wengen Zhu and Chen Liu

    Citation: BMC Medicine 2021 19:44

    Content type: Research article

    Published on:

  14. Following implementation of strong containment measures, several countries and regions have low detectable community transmission of COVID-19. We developed an efficient, rapid, and scalable surveillance strate...

    Authors: K. Lokuge, E. Banks, S. Davis, L. Roberts, T. Street, D. O’Donovan, G. Caleo and K. Glass

    Citation: BMC Medicine 2021 19:50

    Content type: Research article

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  15. Serum transferrin levels represent an independent predictor of mortality in patients with liver failure. Hepatocyte nuclear factor 4 alpha (HNF4α) is a master regulator of hepatocyte functions. The aim of this...

    Authors: Nurdan Guldiken, Josepmaria Argemi, Berivan Gurbuz, Stephen R. Atkinson, Martin Oliverius, Petr Fila, Karim Hamesch, Tony Bruns, Joaquín Cabezas, Juan J. Lozano, Jelena Mann, Sheng Cao, Philippe Mathurin, Vijay H. Shah, Christian Trautwein, Mark R. Thursz…

    Citation: BMC Medicine 2021 19:39

    Content type: Research article

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  16. Despite the growing burden of heart failure (HF), there have been no recommendations for use of any of the primary prevention models in the existing guidelines. HF was also not included as an outcome in the Am...

    Authors: Banafsheh Arshi, Jan C. van den Berge, Bart van Dijk, Jaap W. Deckers, M. Arfan Ikram and Maryam Kavousi

    Citation: BMC Medicine 2021 19:43

    Content type: Research article

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  17. Characteristics of the built environment, such as neighbourhood fast-food outlet exposure, are increasingly recognised as risk factors for unhealthy diet and obesity. Obesity also has a genetic component, with...

    Authors: Thomas Burgoine, Pablo Monsivais, Stephen J. Sharp, Nita G. Forouhi and Nicholas J. Wareham

    Citation: BMC Medicine 2021 19:49

    Content type: Research article

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  18. Neurofilament light chain (NfL) is a cytoskeletal protein component whose release into blood is indicative of neuronal damage. Tau is a microtubule-associated protein in neurons and strongly associated with ov...

    Authors: Nicole Rübsamen, Aleksandra Maceski, David Leppert, Pascal Benkert, Jens Kuhle, Heinz Wiendl, Annette Peters, André Karch and Klaus Berger

    Citation: BMC Medicine 2021 19:38

    Content type: Research article

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  19. Adults increasingly live and die with chronic progressive conditions into advanced age. Many live with multimorbidity and an uncertain illness trajectory with points of marked decline, loss of function and inc...

    Authors: Catherine J. Evans, Laura Potts, Ursula Dalrymple, Andrew Pring, Julia Verne, Irene J. Higginson and Wei Gao

    Citation: BMC Medicine 2021 19:48

    Content type: Research article

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  20. Chronic inflammation, which can be modulated by diet, is linked to high white blood cell counts and correlates with higher cardiometabolic risk and risk of more severe infections, as in the case of COVID-19.

    Authors: Cristina Menni, Panayiotis Louca, Sarah E. Berry, Amrita Vijay, Stuart Astbury, Emily R. Leeming, Rachel Gibson, Francesco Asnicar, Gianmarco Piccinno, Jonathan Wolf, Richard Davies, Massimo Mangino, Nicola Segata, Tim D. Spector and Ana M. Valdes

    Citation: BMC Medicine 2021 19:37

    Content type: Research article

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  21. All countries are facing decisions about which population groups to prioritize for access to COVID-19 vaccination after the first vaccine products have been licensed, at which time supply shortages are inevita...

    Authors: Juan Yang, Wen Zheng, Huilin Shi, Xuemei Yan, Kaige Dong, Qian You, Guangjie Zhong, Hui Gong, Zhiyuan Chen, Mark Jit, Cecile Viboud, Marco Ajelli and Hongjie Yu

    Citation: BMC Medicine 2021 19:45

    Content type: Research article

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  22. The cardiovascular health index (CVHI) introduced by the American Heart Association is a valid, accessible, simple, and translatable metric for monitoring cardiovascular health in a population. Components of t...

    Authors: Engelbert A. Nonterah, Nigel J. Crowther, Abraham Oduro, Godfred Agongo, Lisa K. Micklesfield, Palwendé R. Boua, Solomon S. R. Choma, Shukri F. Mohamed, Herman Sorgho, Stephen M. Tollman, Shane A. Norris, Frederick J. Raal, Diederick E. Grobbee, Michelé Ramsay, Michiel L. Bots and Kerstin Klipstein-Grobusch

    Citation: BMC Medicine 2021 19:30

    Content type: Research article

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  23. The Southern European Atlantic Diet (SEAD) is the traditional diet of Northern Portugal and North-Western Spain. Higher adherence to the SEAD has been associated with lower levels of some cardiovascular risk f...

    Authors: Adrián Carballo-Casla, Rosario Ortolá, Esther García-Esquinas, Andreia Oliveira, Mercedes Sotos-Prieto, Carla Lopes, Esther Lopez-Garcia and Fernando Rodríguez-Artalejo

    Citation: BMC Medicine 2021 19:36

    Content type: Research article

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  24. The frailty index (FI) is a well-recognized measurement for risk stratification in older people. Among middle-aged and older people, we examined the prospective association between the FI and mortality as well...

    Authors: R. C. Oude Voshaar, H. W. Jeuring, M. K. Borges, R. H. S. van den Brink, R. M. Marijnissen, E. O. Hoogendijk, B. van Munster and I. Aprahamian

    Citation: BMC Medicine 2021 19:29

    Content type: Research article

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  25. Preterm birth affects almost 9–11% of newborns and is one of the leading causes of childhood neurodevelopmental disabilities; the underlying molecular networks are poorly defined. In neurons, retrotransposons ...

    Authors: Camilla Fontana, Federica Marasca, Livia Provitera, Sara Mancinelli, Nicola Pesenti, Shruti Sinha, Sofia Passera, Sergio Abrignani, Fabio Mosca, Simona Lodato, Beatrice Bodega and Monica Fumagalli

    Citation: BMC Medicine 2021 19:42

    Content type: Research article

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  26. Non-pharmaceutical interventions (NPIs) are used to reduce transmission of SARS coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19). However, empirical evidence of the effectiveness of s...

    Authors: Yang Liu, Christian Morgenstern, James Kelly, Rachel Lowe and Mark Jit

    Citation: BMC Medicine 2021 19:40

    Content type: Research article

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  27. There is little information on care-seeking patterns for sexual assault and domestic violence during the COVID-19 pandemic. The objective of this study was to examine the changes in emergency department (ED) a...

    Authors: Katherine A. Muldoon, Kathryn M. Denize, Robert Talarico, Deshayne B. Fell, Agnes Sobiesiak, Melissa Heimerl and Kari Sampsel

    Citation: BMC Medicine 2021 19:20

    Content type: Research article

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  28. With increasing life expectancy in China, no large population-based studies have been done on the trend for musculoskeletal disorders in China. We have investigated the pattern and trend of five major musculos...

    Authors: Dongze Wu, Priscilla Wong, Cui Guo, Lai-Shan Tam and Jieruo Gu

    Citation: BMC Medicine 2021 19:34

    Content type: Research article

    Published on:

  29. The COVID-19 pandemic has disrupted routine measles immunisation and supplementary immunisation activities (SIAs) in most countries including Kenya. We assessed the risk of measles outbreaks during the pandemi...

    Authors: C. N. Mburu, J. Ojal, R. Chebet, D. Akech, B. Karia, J. Tuju, A. Sigilai, K. Abbas, M. Jit, S. Funk, G. Smits, P. G. M. van Gageldonk, F. R. M. van der Klis, C. Tabu, D. J. Nokes, JAG Scott…

    Citation: BMC Medicine 2021 19:35

    Content type: Research article

    Published on:

  30. To manage the risk factors and to improve clinical outcomes, patients with stroke commonly receive multiple cardiovascular medications. However, there is a lack of evidence on the optimum combination of medica...

    Authors: Tian-Tian Ma, Ian C. K. Wong, Cate Whittlesea, Kenneth K. C. Man, Wallis Lau, Zixuan Wang, Ruth Brauer, Thomas M. MacDonald, Isla S. Mackenzie and Li Wei

    Citation: BMC Medicine 2021 19:24

    Content type: Research article

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  31. A critical and challenging process in immunotherapy is to identify cancer patients who could benefit from immune checkpoint inhibitors (ICIs). Exploration of predictive biomarkers could help to maximize the cl...

    Authors: Zhen Zhang, Hao-Xiang Wu, Wu-Hao Lin, Zi-Xian Wang, Lu-Ping Yang, Zhao-Lei Zeng and Hui-Yan Luo

    Citation: BMC Medicine 2021 19:26

    Content type: Research article

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  32. Although there are many clinical and molecular biomarkers in acute myeloid leukemia (AML), the novel and reliable biomarkers are still required to predict the overall survival at the time of disease diagnosis.

    Authors: Jinghan Wang, Jiajia Pan, Shujuan Huang, Fenglin Li, Jiansong Huang, Xia Li, Qing Ling, Wenle Ye, Yungui Wang, Wenjuan Yu and Jie Jin

    Citation: BMC Medicine 2021 19:28

    Content type: Research article

    Published on:

  33. SARS-CoV-2 has induced a worldwide pandemic and subsequent non-pharmaceutical interventions (NPIs) to control the spread of the virus. As in many countries, the SARS-CoV-2 pandemic in Germany has led to a cons...

    Authors: Sahamoddin Khailaie, Tanmay Mitra, Arnab Bandyopadhyay, Marta Schips, Pietro Mascheroni, Patrizio Vanella, Berit Lange, Sebastian C. Binder and Michael Meyer-Hermann

    Citation: BMC Medicine 2021 19:32

    Content type: Research article

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  34. Sex hormones have been suggested to play a role in colorectal cancer (CRC), but their influence on early initiation of CRC remains unknown.

    Authors: Dong Hang, Xiaosheng He, Ane Sørlie Kværner, Andrew T. Chan, Kana Wu, Shuji Ogino, Zhibin Hu, Hongbing Shen, Edward L. Giovannucci and Mingyang Song

    Citation: BMC Medicine 2021 19:18

    Content type: Research article

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  35. Prognostic models developed in general cohorts with a mixture of heart failure (HF) phenotypes, though more widely applicable, are also likely to yield larger prediction errors in settings where the HF phenoty...

    Authors: Yuntao Chen, Adriaan A. Voors, Tiny Jaarsma, Chim C. Lang, Iziah E. Sama, K. Martijn Akkerhuis, Eric Boersma, Hans L. Hillege and Douwe Postmus

    Citation: BMC Medicine 2021 19:21

    Content type: Research article

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  36. Studies systematically screening medications have successfully identified prescription medicines associated with cancer risk. However, adjustment for confounding factors in these studies has been limited. We t...

    Authors: R. D. McDowell, C. Hughes, P. Murchie and C. Cardwell

    Citation: BMC Medicine 2021 19:22

    Content type: Research article

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  37. The World Health Organization (WHO) in 2015 stated that every effort should be made to provide cesarean delivery (CD) for women in need. In China, the two-child policy largely prompts the number of advanced ag...

    Authors: Ci Song, Yan Xu, Yuqing Ding, Yanfang Zhang, Na Liu, Lin Li, Zhun Li, Jiangbo Du, Hua You, Hongxia Ma, Guangfu Jin, Xudong Wang, Hongbing Shen, Yuan Lin, Xiaoqing Jiang and Zhibin Hu

    Citation: BMC Medicine 2021 19:14

    Content type: Research article

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  38. The National Early Warning Score (NEWS2) is currently recommended in the UK for the risk stratification of COVID-19 patients, but little is known about its ability to detect severe cases. We aimed to evaluate ...

    Authors: Ewan Carr, Rebecca Bendayan, Daniel Bean, Matt Stammers, Wenjuan Wang, Huayu Zhang, Thomas Searle, Zeljko Kraljevic, Anthony Shek, Hang T. T. Phan, Walter Muruet, Rishi K. Gupta, Anthony J. Shinton, Mike Wyatt, Ting Shi, Xin Zhang…

    Citation: BMC Medicine 2021 19:23

    Content type: Research article

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  39. In utero exposure to Zika virus (ZIKV) is known to be associated with birth defects. The impact of in utero ZIKV exposure on neurodevelopmental outcomes in early childhood remains unclear. The objective of thi...

    Authors: Rebecca Grant, Olivier Fléchelles, Benoît Tressières, Mama Dialo, Narcisse Elenga, Nicolas Mediamolle, Adeline Mallard, Jean-Christophe Hebert, Noémie Lachaume, Elvire Couchy, Bruno Hoen and Arnaud Fontanet

    Citation: BMC Medicine 2021 19:12

    Content type: Research article

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    The Commentary to this article has been published in BMC Medicine 2021 19:41

  40. Much progress has been made in mapping genetic abnormalities linked to amyotrophic lateral sclerosis (ALS), but the majority of cases still present with no known underlying cause. Furthermore, even in families...

    Authors: Sarah L. Boddy, Ilaria Giovannelli, Matilde Sassani, Johnathan Cooper-Knock, Michael P. Snyder, Eran Segal, Eran Elinav, Lynne A. Barker, Pamela J. Shaw and Christopher J. McDermott

    Citation: BMC Medicine 2021 19:13

    Content type: Review

    Published on:

  41. It has been well established that the TMEM106B gene rs1990622 variant was a frontotemporal dementia (FTD) risk factor. Until recently, growing evidence highlights the role of TMEM106B in Alzheimer’s disease (AD)....

    Authors: Yang Hu, Jing-yi Sun, Yan Zhang, Haihua Zhang, Shan Gao, Tao Wang, Zhifa Han, Longcai Wang, Bao-liang Sun and Guiyou Liu

    Citation: BMC Medicine 2021 19:11

    Content type: Research article

    Published on:

  42. Comorbidities affect outcomes in heart failure (HF), but are not reflected in current HF classification. The aim of this study is to characterize HF groups that account for higher-order interactions between co...

    Authors: Claudia Gulea, Rosita Zakeri and Jennifer K. Quint

    Citation: BMC Medicine 2021 19:9

    Content type: Research article

    Published on:

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