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  1. Observational studies made it possible to assess the impact of risk factors on the long-term effectiveness of mRNA and adenoviral vector (AdV) vaccines against COVID-19.

    Authors: Marek Petráš, Roman Máčalík, Daniela Janovská, Alexander M. Čelko, Jana Dáňová, Eliška Selinger, Jonáš Doleček, Sylva Neradová, Martina Franklová, Pavel Dlouhý, Jozef Rosina and Ivana Králová Lesná
    Citation: BMC Medicine 2022 20:461
  2. Smokeless tobacco use is popular in some regions worldwide, but it receives less attention compared to cigarette smoking. We aimed to estimate the recent prevalence of, and trends in, smokeless tobacco use and...

    Authors: Hui Yang, Chuanwei Ma, Min Zhao, Costan G. Magnussen and Bo Xi
    Citation: BMC Medicine 2022 20:460
  3. Young people with diabetes experience poor clinical and psychosocial outcomes, and consider the health service ill-equipped in meeting their needs. Improvements, including alternative consulting approaches, ar...

    Authors: Chrysanthi Papoutsi, Dougal Hargreaves, Ann Hagell, Natalia Hounsome, Helen Skirrow, Koteshwara Muralidhara, Grainne Colligan, Anne Ferrey, Shanti Vijayaraghavan, Trish Greenhalgh and Sarah Finer
    Citation: BMC Medicine 2022 20:459
  4. Pancreatic ductal adenocarcinoma (PDAC) has the lowest overall survival rate primarily due to the late onset of symptoms and rapid progression. Reliable and accurate tests for early detection are lacking. We a...

    Authors: Huanwen Wu, Shiwei Guo, Xiaoding Liu, Yatong Li, Zhixi Su, Qiye He, Xiaoqian Liu, Zhiwen Zhang, Lianyuan Yu, Xiaohan Shi, Suizhi Gao, Huan Wang, Yaqi Pan, Chengcheng Ma, Rui Liu, Menghua Dai…
    Citation: BMC Medicine 2022 20:458
  5. Only a few of the 34 biochemical biomarkers measured in the UK Biobank (UKB) have been associated with breast cancer, with many associations suffering from possible confounding and reverse causation. This stud...

    Authors: Sonja N. Tang, Verena Zuber and Konstantinos K. Tsilidis
    Citation: BMC Medicine 2022 20:457
  6. Supporting decisions for patients who present to the emergency department (ED) with COVID-19 requires accurate prognostication. We aimed to evaluate prognostic models for predicting outcomes in hospitalized pa...

    Authors: David van Klaveren, Theodoros P. Zanos, Jason Nelson, Todd J. Levy, Jinny G. Park, Isabel R. A. Retel Helmrich, Judith A. C. Rietjens, Melissa J. Basile, Negin Hajizadeh, Hester F. Lingsma and David M. Kent
    Citation: BMC Medicine 2022 20:456
  7. We performed phenome-wide Mendelian randomization analysis (MR-PheWAS), two-sample MR analysis, and systemic review to comprehensively explore the health effects of milk consumption in the European population.

    Authors: Shuai Yuan, Jing Sun, Ying Lu, Fengzhe Xu, Doudou Li, Fangyuan Jiang, Zhongxiao Wan, Xue Li, Li-Qiang Qin and Susanna C. Larsson
    Citation: BMC Medicine 2022 20:455
  8. Previous studies have reported that maternal smoking during pregnancy and breastfeeding may affect the occurrence of hypertension, but whether early life factors modify the impact of the offspring’s genetic ri...

    Authors: Jingjia Liang, Zuqiang Fu, Qian Liu, Yuehong Shen, Xin Zhang, Zhenkun Weng, Jin Xu, Wenxiang Li, Cheng Xu, Yong Zhou and Aihua Gu
    Citation: BMC Medicine 2022 20:454
  9. Conteltinib (CT-707) is a potent second-generation anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitor (TKI) showing promising anti-tumor activities in preclinical studies. This study aimed to assess th...

    Authors: Puyuan Xing, Qian Zhao, Li Zhang, Hanping Wang, Dingzhi Huang, Pei Hu, Yinghui Sun and Yuankai Shi
    Citation: BMC Medicine 2022 20:453
  10. Diagnostic testing has been pivotal in detecting SARS-CoV-2 infections and reducing transmission through the isolation of positive cases. We quantified the value of implementing frequent, rapid antigen (RA) te...

    Authors: Thomas N. Vilches, Ellen Rafferty, Chad R. Wells, Alison P. Galvani and Seyed M. Moghadas
    Citation: BMC Medicine 2022 20:452
  11. Glucose metabolism has been reported to be affected by dietary patterns, while the underlying mechanisms involved remain unclear. This study aimed to investigate the potential mediation role of circulating met...

    Authors: Evan Yi-Wen Yu, Zhewen Ren, Siamak Mehrkanoon, Coen D. A. Stehouwer, Marleen M. J. van Greevenbroek, Simone J. P. M. Eussen, Maurice P. Zeegers and Anke Wesselius
    Citation: BMC Medicine 2022 20:450
  12. Previous studies suggested that moderate coffee and tea consumption are associated with lower risk of mortality. However, the association between the combination of coffee and tea consumption with the risk of ...

    Authors: Yanchun Chen, Yuan Zhang, Mengnan Zhang, Hongxi Yang and Yaogang Wang
    Citation: BMC Medicine 2022 20:449
  13. Dihydroartemisinin-piperaquine (DHA-PPQ) is an alternative first-line antimalarial to artemether-lumefantrine in Kenya. However, recent reports on the emergence of PPQ resistance in Southeast Asia threaten its...

    Authors: Dancan M. Wakoli, Bartholomew N. Ondigo, Douglas O. Ochora, Joseph G. Amwoma, Winnie Okore, Edwin W. Mwakio, Gladys Chemwor, Jackeline Juma, Raphael Okoth, Charles Okudo, Redemptah Yeda, Benjamin H. Opot, Agnes C. Cheruiyot, Dennis Juma, Amanda Roth, Benhards R. Ogutu…
    Citation: BMC Medicine 2022 20:448
  14. Preterm birth may affect maternal mental health, yet most studies focus on postpartum mental disorders only. We explored the relationship between preterm delivery and the long-term risk of maternal hospitaliza...

    Authors: Gabriel Côté-Corriveau, Gilles Paradis, Thuy Mai Luu, Aimina Ayoub, Marianne Bilodeau-Bertrand and Nathalie Auger
    Citation: BMC Medicine 2022 20:447
  15. The progression of motor and non-motor symptoms (NMS) and the sensitivity of each item of the Unified Multiple System Atrophy Rating Scale (UMSARS) to change remain unclear in Chinese patients with early-stage...

    Authors: Lingyu Zhang, Yanbing Hou, Bei Cao, Qianqian Wei, Ruwei Ou, Kuncheng Liu, Junyu Lin, Tianmi Yang, Yi Xiao, Yongping Chen, Wei Song, Bi Zhao and Huifang Shang
    Citation: BMC Medicine 2022 20:446
  16. Prednisolone has been suggested as a treatment for olfactory disorders after COVID-19, but evidence is scarce. Hence, we aimed to determine the efficacy of a short oral prednisolone treatment on patients with ...

    Authors: Emma J. A. Schepens, Esther E. Blijleven, Wilbert M. Boek, Sanne Boesveldt, Robert J. Stokroos, Inge Stegeman and Digna M. A. Kamalski
    Citation: BMC Medicine 2022 20:445
  17. There is growing evidence that patients recovering after a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may have a variety of acute sequelae including newly diagnosed diabetes. Howeve...

    Authors: Ting Zhang, Qimin Mei, Zhaocai Zhang, Joseph Harold Walline, Yecheng Liu, Huadong Zhu and Shuyang Zhang
    Citation: BMC Medicine 2022 20:444
  18. Several recent observational studies have reported that gut microbiota composition is associated with preeclampsia. However, the causal effect of gut microbiota on preeclampsia-eclampsia is unknown.

    Authors: Pengsheng Li, Haiyan Wang, Lan Guo, Xiaoyan Gou, Gengdong Chen, Dongxin Lin, Dazhi Fan, Xiaoling Guo and Zhengping Liu
    Citation: BMC Medicine 2022 20:443
  19. The SARS-CoV-2 containment strategy has been successful in mainland China prior to the emergence of Omicron. However, in the era of highly transmissible variants, whether it is possible for China to sustain a ...

    Authors: Yan Wang, Kaiyuan Sun, Zhaomin Feng, Lan Yi, Yanpeng Wu, Hengcong Liu, Quanyi Wang, Marco Ajelli, Cécile Viboud and Hongjie Yu
    Citation: BMC Medicine 2022 20:442
  20. Low-density Plasmodium falciparum infections prevail in low transmission settings, where immunity is expected to be minimal, suggesting an immune-independent effect on parasite densities. We aimed to describe par...

    Authors: Glória Matambisso, Nanna Brokhattingen, Sónia Maculuve, Pau Cisteró, Henriques Mbeve, Anna Escoda, Judice Miguel, Elena Buetas, Ianthe de Jong, Boaventura Cuna, Cardoso Melembe, Nelo Ndimande, Gemma Porras, Haily Chen, Kevin K. A. Tetteh, Chris Drakeley…
    Citation: BMC Medicine 2022 20:396
  21. Aggressive lipid lowering by high-dose statin treatment has been established for the secondary prevention of coronary artery disease (CAD). Regarding the low-density lipoprotein cholesterol (LDL-C) level, howe...

    Authors: Masashi Sakuma, Satoshi Iimuro, Tomohiro Shinozaki, Takeshi Kimura, Yoshihisa Nakagawa, Yukio Ozaki, Hiroshi Iwata, Katsumi Miyauchi, Hiroyuki Daida, Satoru Suwa, Ichiro Sakuma, Yosuke Nishihata, Yasushi Saito, Hisao Ogawa, Masunori Matsuzaki, Yasuo Ohashi…
    Citation: BMC Medicine 2022 20:441
  22. Tuberculosis remains a major public health priority and is the second leading cause of mortality from infectious disease worldwide. TB case detection rates are unacceptably low for men, the elderly and childre...

    Authors: C. Finn McQuaid, Marc Y. R. Henrion, Rachael M. Burke, Peter MacPherson, Rebecca Nzawa-Soko and Katherine C. Horton
    Citation: BMC Medicine 2022 20:432
  23. Due to the blood-brain barrier, plasma is not an ideal source to evaluate the genetic characteristics of central nervous system tumors. Thus, cerebrospinal fluid (CSF) is becoming an alternative biopsy type to...

    Authors: Meichen Li, Jing Chen, Baishen Zhang, Juan Yu, Na Wang, Delan Li, Yang Shao, Dongqin Zhu, Chuqiao Liang, Yutong Ma, Qiuxiang Ou, Xue Hou and Likun Chen
    Citation: BMC Medicine 2022 20:398
  24. Untreated celiac disease (CD) patients have increased levels of blood glutamine and a lower duodenal expression of glutaminase (GLS). Intestinal gluconeogenesis (IGN) is a process through which glutamine is tu...

    Authors: Olof Karlson, Henrik Arnell, Audur H. Gudjonsdottir, Daniel Agardh and Åsa Torinsson Naluai
    Citation: BMC Medicine 2022 20:440
  25. The effect of frailty and poor cardiovascular health on mortality for males and females is not fully elucidated. We investigated whether the combined burden of frailty and poor cardiovascular health is associa...

    Authors: Jack Quach, Olga Theou, Judith Godin, Kenneth Rockwood and Dustin Scott Kehler
    Citation: BMC Medicine 2022 20:394
  26. Individuals with a family history of colorectal cancer (CRC) are at a high risk of developing CRC. Preclinical studies suggest that the anti-malaria drug proguanil and atovaquone might play a role in preventin...

    Authors: Naiqi Zhang, Jan Sundquist, Kristina Sundquist and Jianguang Ji
    Citation: BMC Medicine 2022 20:439
  27. Myotonic dystrophy type 1 (DM1) is an incurable multisystem disease caused by a CTG-repeat expansion in the DM1 protein kinase (DMPK) gene. The OPTIMISTIC clinical trial demonstrated positive and heterogenous eff...

    Authors: Remco T. P. van Cruchten, Daniël van As, Jeffrey C. Glennon, Baziel G. M. van Engelen and Peter A. C. ‘t Hoen
    Citation: BMC Medicine 2022 20:395
  28. Risk profiles for premature cardiovascular disease (CVD) are unclear. This study aimed to examine baseline risk profiles for incident CVD by age at onset in Chinese population.

    Authors: Xue Tian, Shuohua Chen, Yingting Zuo, Yijun Zhang, Xiaoli Zhang, Qin Xu, Yanxia Luo, Shouling Wu and Anxin Wang
    Citation: BMC Medicine 2022 20:383
  29. Various stakeholders are calling for increased availability of data and code from cancer research. However, it is unclear how commonly these products are shared, and what factors are associated with sharing. O...

    Authors: Daniel G. Hamilton, Matthew J. Page, Sue Finch, Sarah Everitt and Fiona Fidler
    Citation: BMC Medicine 2022 20:438
  30. Cervical squamous cell carcinoma (SCC) is known to arise through increasingly higher-grade squamous intraepithelial lesions (SILs) or cervical intraepithelial neoplasias (CINs). This study aimed to describe se...

    Authors: Jianwei Zhang, Silu Meng, Xiaoyan Wang, Jun Wang, Xinran Fan, Haiying Sun, Ruoqi Ning, Bing Xiao, Xiangqin Li, Yao Jia, Dongli Kong, Ruqi Chen, Changyu Wang, Ding Ma and Shuang Li
    Citation: BMC Medicine 2022 20:437
  31. A major hand-foot-and-mouth disease (HFMD) pathogen, coxsackievirus A16 (CVA16), has predominated in several of the last 10 years and caused the largest number of HFMD outbreaks between 2011 and 2018 in China....

    Authors: Jiaxin Zhou, Yonghong Zhou, Kaiwei Luo, Qiaohong Liao, Wen Zheng, Hui Gong, Huilin Shi, Shanlu Zhao, Kai Wang, Qi Qiu, Bingbing Dai, Lingshuang Ren, Lili Wang, Lidong Gao, Meng Xu, Nuolan Liu…
    Citation: BMC Medicine 2022 20:436
  32. Although immune checkpoint inhibitors (ICIs) have influenced the treatment paradigm for multiple solid tumors, increasing evidence suggests that primary and adaptive resistance may limit the long-term efficacy...

    Authors: Pei Zhang, Yang Du, Hua Bai, Zhijie Wang, Jianchun Duan, Xin Wang, Jia Zhong, Rui Wan, Jiachen Xu, Xiran He, Di Wang, Kailun Fei, Ruofei Yu, Jie Tian and Jie Wang
    Citation: BMC Medicine 2022 20:435
  33. Human papillomavirus (HPV) vaccination and intensifying screening expedite cervical cancer (CC) elimination, yet also deteriorate the balance between harms and benefits of screening. We aimed to find screening...

    Authors: Erik E. L. Jansen, Inge M. C. M. de Kok, Sylvia Kaljouw, Erhan Demirel, Harry J. de Koning and Jan. A. C. Hontelez
    Citation: BMC Medicine 2022 20:433
  34. Non-alcoholic fatty liver disease (NAFLD) can lead to pulmonary dysfunction that is associated with pulmonary inflammation. Moreover, little is known regarding the therapeutic role of exercise training on pulm...

    Authors: Jinkyung Cho, Bruce D. Johnson, Kymberly D. Watt, Alexander S. Niven, Dongwook Yeo and Chul-Ho Kim
    Citation: BMC Medicine 2022 20:429
  35. The empirical evidence remains inconclusive for an association between diabetes mellitus (DM) in children and early-onset kidney disease later in life, and little is known about the effects of DM types (i.e., ...

    Authors: Jiahong Sun, Ce Wang, Min Zhao, Priscilla M. Y. Lee, Bo Xi, Yongfu Yu and Jiong Li
    Citation: BMC Medicine 2022 20:428
  36. The influence of maternal levothyroxine treatment during pregnancy remains unclear. This study aimed to evaluate the associations of maternal levothyroxine treatment during pregnancy with the birth and neurode...

    Authors: Grace Mengqin Ge, Edmund C. L. Cheung, Kenneth K. C. Man, Patrick Ip, Wing Cheong Leung, Gloria H. Y. Li, Annie W. C. Kung, Ching-Lung Cheung and Ian C. K. Wong
    Citation: BMC Medicine 2022 20:390
  37. Currently, immunotherapy is widely used in the treatment of various stages of non-small cell lung cancer. According to clinical experience and results of previous studies, immunotherapy as neoadjuvant therapy ...

    Authors: Yimin Wang, Chuling Li, Zimu Wang, Zhaofeng Wang, Ranpu Wu, Ying Wu, Yong Song and Hongbing Liu
    Citation: BMC Medicine 2022 20:426
  38. The COVID-19 pandemic has highlighted the importance of evidence-based clinical decision-making. Clinical management guidelines (CMGs) may help reduce morbidity and mortality by improving the quality of clinic...

    Authors: Ishmeala Rigby, Melina Michelen, Vincent Cheng, Andrew Dagens, Dania Dahmash, Samuel Lipworth, Eli Harriss, Erhui Cai, Valeria Balan, Alexandra Oti, Reena Joseph, Helen Groves, Peter Hart, Shevin Jacob, Lucille Blumberg, Peter W. Horby…
    Citation: BMC Medicine 2022 20:425
  39. Language deficits frequently occur during the prodromal stages of Alzheimer’s disease (AD). However, the characteristics of linguistic impairment and its underlying mechanism(s) remain to be explored for the e...

    Authors: Hua-Long Wang, Ran Tang, Ru-Jing Ren, Eric B. Dammer, Qi-Hao Guo, Guo-Ping Peng, Hai-Lun Cui, You-Min Zhang, Jin-Tao Wang, Xin-Yi Xie, Qiang Huang, Jian-Ping Li, Fu-Hua Yan, Sheng-Di Chen, Na-Ying He and Gang Wang
    Citation: BMC Medicine 2022 20:380
  40. The Accelerating Innovation for Mothers (AIM) project established a database of candidate medicines in research and development (R&D) between 2000 and 2021 for five pregnancy-related conditions, including pre-...

    Authors: Annie R. A. McDougall, Roxanne Hastie, Maya Goldstein, Andrew Tuttle, Stephen Tong, Anne Ammerdorffer, A. Metin Gülmezoglu and Joshua P. Vogel
    Citation: BMC Medicine 2022 20:393
  41. Gestational age (GA) is associated with later cognition and behavior. However, it is unclear how specific cognitive domains and brain structural development varies with the stepwise change of gestational durat...

    Authors: Qing Ma, Hui Wang, Edmund T. Rolls, Shitong Xiang, Jiong Li, Yuzhu Li, Qiongjie Zhou, Wei Cheng and Fei Li
    Citation: BMC Medicine 2022 20:424
  42. Oral mucositis (OM) in patients receiving cancer therapy is thus far not well managed with standard approaches. We aimed to assess the safety and effectiveness of methylene blue (MB) oral rinse for OM pain in ...

    Authors: Carlos J. Roldan, Billy Huh, Juhee Song, Yago Nieto, Joyce Osei, Thomas Chai, Kent Nouri, Lakshmi Koyyalagunta and Eduardo Bruera
    Citation: BMC Medicine 2022 20:377
  43. Epidemiological studies have reported an association between amyotrophic lateral sclerosis (ALS) and different autoimmune disorders. This study aims to explore the causal relationship between autoimmune disord...

    Authors: Paria Alipour, Konstantin Senkevich, Jay P. Ross, Dan Spiegelman, Despoina Manousaki, Patrick A. Dion and Guy A. Rouleau
    Citation: BMC Medicine 2022 20:382