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  1. Research article

    Metabonomics uncovers a reversible proatherogenic lipid profile during infliximab therapy of inflammatory bowel disease

    One-third of inflammatory bowel disease (IBD) patients show no response to infliximab (IFX) induction therapy, and approximately half of patients responding become unresponsive over time. Thus, identification ...

    Jacob Tveiten Bjerrum, Casper Steenholdt, Mark Ainsworth, Ole Haagen Nielsen, Michelle AC Reed, Karen Atkins, Ulrich Leonhard Günther, Fuhua Hao and Yulan Wang

    BMC Medicine 2017 15:184

    Published on: 16 October 2017

  2. Research article

    Plasmodium falciparum EPCR-binding PfEMP1 expression increases with malaria disease severity and is elevated in retinopathy negative cerebral malaria

    Expression of group A and the A-like subset of group B Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is associated with severe malaria (SM). The diversity of var sequences combined with the challe...

    Estela Shabani, Benjamin Hanisch, Robert O. Opoka, Thomas Lavstsen and Chandy C. John

    BMC Medicine 2017 15:183

    Published on: 13 October 2017

  3. Research article

    Spatial model for risk prediction and sub-national prioritization to aid poliovirus eradication in Pakistan

    Pakistan is one of only three countries where poliovirus circulation remains endemic. For the Pakistan Polio Eradication Program, identifying high risk districts is essential to target interventions and alloca...

    Laina D. Mercer, Rana M. Safdar, Jamal Ahmed, Abdirahman Mahamud, M. Muzaffar Khan, Sue Gerber, Aiden O’Leary, Mike Ryan, Frank Salet, Steve J. Kroiss, Hil Lyons, Alexander Upfill-Brown and Guillaume Chabot-Couture

    BMC Medicine 2017 15:180

    Published on: 11 October 2017

  4. Research article

    A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria

    The clinical development of a single encounter treatment for uncomplicated malaria has the potential to significantly improve the effectiveness of antimalarials. Exploratory data suggested that the combination...

    Fiona Macintyre, Yeka Adoke, Alfred B. Tiono, Tran Thanh Duong, Ghyslain Mombo-Ngoma, Marielle Bouyou-Akotet, Halidou Tinto, Quique Bassat, Saadou Issifou, Marc Adamy, Helen Demarest, Stephan Duparc, Didier Leroy, Bart E. Laurijssens, Sophie Biguenet, Afizi Kibuuka…

    BMC Medicine 2017 15:181

    Published on: 9 October 2017

  5. Research article

    The cost determinants of routine infant immunization services: a meta-regression analysis of six country studies

    Evidence on immunization costs is a critical input for cost-effectiveness analysis and budgeting, and can describe variation in site-level efficiency. The Expanded Program on Immunization Costing and Financing...

    Nicolas A. Menzies, Christian Suharlim, Fangli Geng, Zachary J. Ward, Logan Brenzel and Stephen C. Resch

    BMC Medicine 2017 15:178

    Published on: 6 October 2017

  6. Research article

    The risk of type 2 oral polio vaccine use in post-cessation outbreak response

    Wild type 2 poliovirus was last observed in 1999. The Sabin-strain oral polio vaccine type 2 (OPV2) was critical to eradication, but it is known to revert to a neurovirulent phenotype, causing vaccine-associat...

    Kevin A. McCarthy, Guillaume Chabot-Couture, Michael Famulare, Hil M. Lyons and Laina D. Mercer

    BMC Medicine 2017 15:175

    Published on: 4 October 2017

  7. Correspondence

    Can learning health systems help organisations deliver personalised care?

    There is increasing international policy and clinical interest in developing learning health systems and delivering precision medicine, which it is hoped will help reduce variation in the quality and safety of...

    Bright I. Nwaru, Charles Friedman, John Halamka and Aziz Sheikh

    BMC Medicine 2017 15:177

    Published on: 2 October 2017

  8. Guideline

    Towards new recommendations to reduce the burden of alcohol-induced hypertension in the European Union

    Hazardous and harmful alcohol use and high blood pressure are central risk factors related to premature non-communicable disease (NCD) mortality worldwide. A reduction in the prevalence of both risk factors ha...

    Jürgen Rehm, Peter Anderson, Jose Angel Arbesu Prieto, Iain Armstrong, Henri-Jean Aubin, Michael Bachmann, Nuria Bastida Bastus, Carlos Brotons, Robyn Burton, Manuel Cardoso, Joan Colom, Daniel Duprez, Gerrit Gmel, Antoni Gual, Ludwig Kraus, Reinhold Kreutz…

    BMC Medicine 2017 15:173

    Published on: 28 September 2017

  9. Research article

    Continental-scale, data-driven predictive assessment of eliminating the vector-borne disease, lymphatic filariasis, in sub-Saharan Africa by 2020

    There are growing demands for predicting the prospects of achieving the global elimination of neglected tropical diseases as a result of the institution of large-scale nation-wide intervention programs by the ...

    Edwin Michael, Brajendra K. Singh, Benjamin K. Mayala, Morgan E. Smith, Scott Hampton and Jaroslaw Nabrzyski

    BMC Medicine 2017 15:176

    Published on: 27 September 2017

  10. Review

    Is Graves’ disease a primary immunodeficiency? New immunological perspectives on an endocrine disease

    Uncertainty about factors influencing the susceptibility and triggers for Graves’ disease persists, along with a wide variation in the response to anti-thyroid drugs, currently at approximately 50% of non-resp...

    Tristan Struja, Alexander Kutz, Stefan Fischli, Christian Meier, Beat Mueller, Mike Recher and Philipp Schuetz

    BMC Medicine 2017 15:174

    Published on: 25 September 2017

  11. Research article

    A 25-gene classifier predicts overall survival in resectable pancreatic cancer

    Pancreatic carcinoma is one of the most lethal human cancers. In patients with resectable tumors, surgery followed by adjuvant chemotherapy is the only curative treatment. However, the 5-year survival is 20%. ...

    David J. Birnbaum, Pascal Finetti, Alexia Lopresti, Marine Gilabert, Flora Poizat, Jean-Luc Raoul, Jean-Robert Delpero, Vincent Moutardier, Daniel Birnbaum, Emilie Mamessier and François Bertucci

    BMC Medicine 2017 15:170

    Published on: 20 September 2017

  12. Research article

    Macrophage activation-like syndrome: an immunological entity associated with rapid progression to death in sepsis

    A subanalysis of a randomized clinical trial indicated sepsis survival benefit from interleukin (IL)-1 blockade in patients with features of the macrophage activation-like syndrome (MALS). This study aimed to ...

    Evdoxia Kyriazopoulou, Konstantinos Leventogiannis, Anna Norrby-Teglund, Georgios Dimopoulos, Aikaterini Pantazi, Stylianos E. Orfanos, Nikoletta Rovina, Iraklis Tsangaris, Theologia Gkavogianni, Elektra Botsa, Eleftheria Chassiou, Anastasia Kotanidou, Christina Kontouli, Panagiotis Chaloulis, Dimitrios Velissaris, Athina Savva…

    BMC Medicine 2017 15:172

    Published on: 18 September 2017

  13. Research article

    Borrelia infection and risk of celiac disease

    Environmental factors, including infectious agents, are speculated to play a role in the rising prevalence and the geographic distribution of celiac disease, an autoimmune disorder. In the USA and Sweden where...

    Armin Alaedini, Benjamin Lebwohl, Gary P. Wormser, Peter H. Green and Jonas F. Ludvigsson

    BMC Medicine 2017 15:169

    Published on: 15 September 2017

  14. Research article

    Modest heterologous protection after Plasmodium falciparum sporozoite immunization: a double-blind randomized controlled clinical trial

    A highly efficacious vaccine is needed for malaria control and eradication. Immunization with Plasmodium falciparum NF54 parasites under chemoprophylaxis (chemoprophylaxis and sporozoite (CPS)-immunization) induc...

    Jona Walk, Isaie J. Reuling, Marije C. Behet, Lisette Meerstein-Kessel, Wouter Graumans, Geert-Jan van Gemert, Rianne Siebelink-Stoter, Marga van de Vegte-Bolmer, Thorsten Janssen, Karina Teelen, Johannes H. W. de Wilt, Quirijn de Mast, André J. van der Ven, Ernest Diez Benavente, Susana Campino, Taane G. Clark…

    BMC Medicine 2017 15:168

    Published on: 13 September 2017

  15. Correspondence

    Core competencies for scientific editors of biomedical journals: consensus statement

    Scientific editors are responsible for deciding which articles to publish in their journals. However, we have not found documentation of their required knowledge, skills, and characteristics, or the existence ...

    David Moher, James Galipeau, Sabina Alam, Virginia Barbour, Kidist Bartolomeos, Patricia Baskin, Sally Bell-Syer, Kelly D. Cobey, Leighton Chan, Jocalyn Clark, Jonathan Deeks, Annette Flanagin, Paul Garner, Anne-Marie Glenny, Trish Groves, Kurinchi Gurusamy…

    BMC Medicine 2017 15:167

    Published on: 11 September 2017

  16. Research article

    Cost-effectiveness analysis of quadrivalent seasonal influenza vaccines in England

    As part of the national seasonal influenza vaccination programme in England and Wales, children receive a quadrivalent vaccine offering protection against two influenza A strains and two influenza B strains. H...

    Dominic Thorrington, Edwin van Leeuwen, Mary Ramsay, Richard Pebody and Marc Baguelin

    BMC Medicine 2017 15:166

    Published on: 8 September 2017

  17. Research article

    A 13-gene expression-based radioresistance score highlights the heterogeneity in the response to radiation therapy across HPV-negative HNSCC molecular subtypes

    Radiotherapy for head and neck squamous cell carcinomas (HNSCC) is associated with a substantial morbidity and inconsistent efficacy. Human papillomavirus (HPV)-positive status is recognized as a marker of inc...

    Jean-Philippe Foy, Louis Bazire, Sandra Ortiz-Cuaran, Sophie Deneuve, Janice Kielbassa, Emilie Thomas, Alain Viari, Alain Puisieux, Patrick Goudot, Chloé Bertolus, Nicolas Foray, Youlia Kirova, Pierre Verrelle and Pierre Saintigny

    BMC Medicine 2017 15:165

    Published on: 1 September 2017

  18. Research article

    Reduced growth velocity across the third trimester is associated with placental insufficiency in fetuses born at a normal birthweight: a prospective cohort study

    While being small-for-gestational-age due to placental insufficiency is a major risk factor for stillbirth, 50% of stillbirths occur in appropriate-for-gestational-age (AGA, > 10th centile) fetuses. AGA fetuse...

    Teresa M. MacDonald, Lisa Hui, Stephen Tong, Alice J. Robinson, Kirsten M. Dane, Anna L. Middleton and Susan P. Walker

    BMC Medicine 2017 15:164

    Published on: 31 August 2017

  19. Research article

    A pragmatic lifestyle modification programme reduces the incidence of predictors of cardio-metabolic disease and dysglycaemia in a young healthy urban South Asian population: a randomised controlled trial

    There is an increasing incidence of type 2 diabetes mellitus (T2DM) in young urban South-Asians. We tested the effect of a pragmatic trimonthly lifestyle modification (LSM) programme (P-LSM) versus a less-inte...

    Mahen Wijesuriya, Nikolaos Fountoulakis, Nicola Guess, Sarath Banneheka, Laksha Vasantharajah, Martin Gulliford, Giancarlo Viberti, Luigi Gnudi and Janaka Karalliedde

    BMC Medicine 2017 15:146

    Published on: 30 August 2017

  20. Research article

    Trade-off between benefits, harms and economic efficiency of low-dose CT lung cancer screening: a microsimulation analysis of nodule management strategies in a population-based setting

    In lung cancer screening, a nodule management protocol describes nodule assessment and thresholds for nodule size and growth rate to identify patients who require immediate diagnostic evaluation or additional ...

    Marina Treskova, Ines Aumann, Heiko Golpon, Jens Vogel-Claussen, Tobias Welte and Alexander Kuhlmann

    BMC Medicine 2017 15:162

    Published on: 25 August 2017

  21. Research article

    The contribution of risk factors to socioeconomic inequalities in multimorbidity across the lifecourse: a longitudinal analysis of the Twenty-07 cohort

    Multimorbidity is a major challenge to health systems globally and disproportionately affects socioeconomically disadvantaged populations. We examined socioeconomic inequalities in developing multimorbidity ac...

    Srinivasa Vittal Katikireddi, Kathryn Skivington, Alastair H. Leyland, Kate Hunt and Stewart W Mercer

    BMC Medicine 2017 15:152

    Published on: 24 August 2017

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