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  1. The American Heart Association recently introduced a novel cardiovascular health (CVH) metric, Life's Essential 8 (LE8), for health promotion. However, the relationship between LE8 and cancer mortality risk re...

    Authors: Lijin Lin, Yulian Hu, Fang Lei, Xuewei Huang, Xingyuan Zhang, Tao Sun, Weifang Liu, Ru Li, Xiao-Jing Zhang, Jingjing Cai, Zhi-Gang She, Guoping Wang and Hongliang Li
    Citation: BMC Medicine 2024 22:368
    Content type: Research article Published on:

  2. Current cardiovascular prevention strategies are based on studies that seldom include valvular heart disease (VHD). The role of modifiable lifestyle factors on VHD progression and life expectancy among the eld...

    Authors: Yanxia Wei, Dawei Sun, Sanjay Jaiswal, Yuxin He, Xianbao Liu and Jian’an Wang
    Citation: BMC Medicine 2024 22:367
    Content type: Research article Published on:

  3. Associations of dietary sodium and potassium intake with fracture risk are inconsistent and the effects of salt substitute on fracture incidence are unknown. We assessed the effect of salt substitute compared ...

    Authors: Faxuan Wang, Yangyang Pi, Yi Zhao, Yuhong Zhang, Bo Zhou, Zhifang Li, Jixin Sun, Yan Yu, Maoyi Tian, Minghui Yang, Liping Huang, Hongyi Song, Bruce Neal and Katrina R. Kissock
    Citation: BMC Medicine 2024 22:366
    Content type: Research article Published on:

  4. Chemotherapy remains the standard first-line treatment for pancreatic adenocarcinoma, but with limited efficacy. We aimed to explore the feasibility of adding the PARP inhibitor fuzuloparib to mFOLFIRINOX in t...

    Authors: Miaoyan Wei, Rujiao Liu, Yunyun Xu, Xiaobing Chen, Chao Liu, Xueli Bai, Xiaochen Zhang, Shuiping Gao, Jialin Li, Zhen Sheng, Jianpo Lian, Wenliang Wang, Jian Zhang, Si Shi, Jin Xu and Xianjun Yu
    Citation: BMC Medicine 2024 22:365
    Content type: Research article Published on:

  5. The spatiotemporal epidemiological evidence supporting joint endoscopic screening for esophageal cancer (EC) and gastric cancer (GC) remains limited. This study aims to identify combined high-risk regions for ...

    Authors: Peng Li, Xin Qi, Ruhai Bai, Mei Yang, Jing Jing, Ruyi Xia, Jizhao Wang, Guangjian Zhang and Guihua Zhuang
    Citation: BMC Medicine 2024 22:364
    Content type: Research Published on:

  6. Aggressive malignancies, such as pancreatic cancer, are increasingly impacting young, female populations. Our investigation centered on whether the observed trends in cancer incidence were unique to pancreatic...

    Authors: Alessandro Cavazzani, Claudia Angelini, Dario Gregori and Luca Cardone
    Citation: BMC Medicine 2024 22:363
    Content type: Research Published on:

  7. Obesity and metabolic syndrome (MetS) have become urgent worldwide health problems, predisposing patients to unfavorable myocardial status and thyroid dysfunction. Low-carbohydrate diet (LCD) and time-restrict...

    Authors: Yixuan Zheng, Jingya Wang, Mengmeng Liu, Xingchen Zhou, Xiaoying Lin, Qian Liang, Jing Yang, Meng Zhang, Ziyi Chen, Meng Li, Yue Wang, Jing Sui, Wei Qiang, Hui Guo, Bingyin Shi and Mingqian He
    Citation: BMC Medicine 2024 22:362
    Content type: Research article Published on:

  8. Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiomyopathy characterized with progressive cardiac fibrosis and heart failure. However, the exact mechanism driving the progression of cardiac fibrosis an...

    Authors: Baowei Zhang, Yizhang Wu, Chunjiang Zhou, Jiaxi Xie, Youming Zhang, Xingbo Yang, Jing Xiao, Dao Wu Wang, Congjia Shan, Xiujuan Zhou, Yaozu Xiang and Bing Yang
    Citation: BMC Medicine 2024 22:361
    Content type: Research Published on:

  9. The study assessed the association between COVID-19 and new-onset obstructive airway diseases, including asthma, chronic obstructive pulmonary disease, and bronchiectasis among vaccinated individuals recoverin...

    Authors: Min-Hsiang Chuang, Wei Hsu, Ya-Wen Tsai, Wan-Hsuan Hsu, Jheng-Yan Wu, Ting-Hui Liu, Po-Yu Huang and Chih-Cheng Lai
    Citation: BMC Medicine 2024 22:360
    Content type: Research Published on:

  10. Psychological and trauma-related factors are associated with many diseases and mortality. However, a comprehensive assessment of the association between psycho-trauma exposures and aging acceleration is curren...

    Authors: Junren Wang, Xin Han, Yao Yang, Yu Zeng, Yuanyuan Qu, Huazhen Yang, Jie Song, Changjian Qiu and Huan Song
    Citation: BMC Medicine 2024 22:359
    Content type: Research article Published on:

  11. Individuals with non-celiac gluten/wheat sensitivity (NCGWS) experience improvement in gastrointestinal symptoms following a gluten-free diet. Although previous results have indicated that fructo-oligosacchari...

    Authors: Anne Mari Herfindal, Morten Nilsen, Trude E. Aspholm, Gry I. G. Schultz, Jørgen Valeur, Knut Rudi, Magne Thoresen, Knut E. A. Lundin, Christine Henriksen and Siv K. Bøhn
    Citation: BMC Medicine 2024 22:358
    Content type: Research Published on:

  12. Our previous genome‑wide association studies (GWAS) have suggested rs912304 in 14q12 as a suggestive risk variant for type 1 diabetes (T1D). However, the association between this risk region and T1D subgroups ...

    Authors: Yu Qian, Shu Chen, Yan Wang, Yuyue Zhang, Jie Zhang, Liying Jiang, Hao Dai, Min Shen, Yunqiang He, Hemin Jiang, Tao Yang, Qi Fu and Kuanfeng Xu
    Citation: BMC Medicine 2024 22:357
    Content type: Research Published on:

  13. This review seeks to address major gaps and delays between our rapidly evolving body of knowledge on type 2 diabetes and its translation into real-world practice. Through updated and improved best practices in...

    Authors: Stanley S. Schwartz, Barbara E. Corkey, James R Gavin 3rd, Ralph A. DeFronzo and Mary E. Herman
    Citation: BMC Medicine 2024 22:356
    Content type: Review Published on:

  14. Sex disparity between metabolic-obesity (defined by body mass index, BMI) phenotypes and obesity-related cancer (ORC) remains unknown. Considering BMI reflecting overall obesity but not fat distribution, we ai...

    Authors: Jianxiao Gong, Fubin Liu, Yu Peng, Peng Wang, Changyu Si, Xixuan Wang, Huijun Zhou, Jiale Gu, Ailing Qin and Fangfang Song
    Citation: BMC Medicine 2024 22:355
    Content type: Research article Published on:

  15. The integration of machine learning (ML) and artificial intelligence (AI) techniques in life-course epidemiology offers remarkable opportunities to advance our understanding of the complex interplay between bi...

    Authors: Shanquan Chen, Jiazhou Yu, Sarah Chamouni, Yuqi Wang and Yunfei Li
    Citation: BMC Medicine 2024 22:354
    Content type: Review Published on:

  16. Higher cruciferous vegetable intake is associated with lower cardiovascular disease risk in observational studies. The pathways involved remain uncertain. We aimed to determine whether cruciferous vegetable in...

    Authors: Emma L. Connolly, Alex H. Liu, Simone Radavelli-Bagatini, Armaghan Shafaei, Mary C. Boyce, Lisa G. Wood, Lyn McCahon, Henrietta Koch, Marc Sim, Caroline R. Hill, Benjamin H. Parmenter, Nicola P. Bondonno, Amanda Devine, Kevin D. Croft, Richard Mithen, Seng Khee Gan…
    Citation: BMC Medicine 2024 22:353
    Content type: Research article Published on:

  17. The radiogenomic analysis has provided valuable imaging biomarkers with biological insights for gliomas. The radiogenomic markers for molecular profile such as DNA methylation remain to be uncovered to assist ...

    Authors: Zhuokai Zhuang, Jinxin Lin, Zixiao Wan, Jingrong Weng, Ze Yuan, Yumo Xie, Zongchao Liu, Peiyi Xie, Siyue Mao, Zongming Wang, Xiaolin Wang, Meijin Huang, Yanxin Luo and Huichuan Yu
    Citation: BMC Medicine 2024 22:352
    Content type: Research Published on:

  18. Endometriosis is well known as a chronic inflammatory disease. The development of endometriosis is heavily influenced by the estrogen receptor β (ERβ), while NOD-like receptors (NLRs) family CARD domain-contai...

    Authors: Bao Guo, Haiqing Zhu, Chengwei Xiao, Jing Zhang, Xiaojing Liu, Yuan Fang, Bing Wei, Junhui Zhang, Yunxia Cao and Lei Zhan
    Citation: BMC Medicine 2024 22:351
    Content type: Research Published on:

  19. The number of people with palliative care needs is projected to increase globally. Chile has recently introduced legislation for universal access to palliative care services for patients with severe and termin...

    Authors: Javiera Leniz, Angélica Domínguez, Anna E. Bone, Simon Etkind, Pedro E. Perez-Cruz and Katherine E. Sleeman
    Citation: BMC Medicine 2024 22:350
    Content type: Research article Published on:

  20. Improving food environments like supermarkets has the potential to affect customers’ health positively. Scholars suggest researchers and retailers collaborate closely on implementing and testing such health-pr...

    Authors: Katrine Sidenius Duus, Tine Tjørnhøj-Thomsen and Rikke Fredenslund Krølner
    Citation: BMC Medicine 2024 22:349
    Content type: Research Published on:

  21. School-based water, sanitation and hygiene (WASH) may improve the health and attendance of schoolchildren, particularly post-menarcheal girls, but existing evidence is mixed. We examined the impact of an urban...

    Authors: Sarah Bick, Alem Ezezew, Charles Opondo, Baptiste Leurent, Wossen Argaw, Erin C. Hunter, Oliver Cumming, Elizabeth Allen and Robert Dreibelbis
    Citation: BMC Medicine 2024 22:348
    Content type: Research Published on:

  22. Medication Treatment Satisfaction (M-TS) from the patients’ perspective is important for comprehensively evaluating the effect of medicines. The extent to which current patient-reported outcome measures (PROMs...

    Authors: Mengting Yang, Puwen Zhang, Jillian Halladay, Kun Zou, Imti Choonara, Xiaorui Ji, Shuya Zhang, Weiyi Yan, Liang Huang, Xiaoxi Lu, Huiqing Wang, Yuxin Jiang, Xinyu Liu, Linan Zeng, Lingli Zhang and Gordon H. Guyatt
    Citation: BMC Medicine 2024 22:347
    Content type: Research article Published on:

  23. Limited data exists regarding gender-specific microbial alterations during gender-affirming hormonal therapy (GAHT) in transgender individuals. This study aimed to investigate the nuanced impact of sex steroid...

    Authors: Timur Liwinski, Matthias K. Auer, Johanna Schröder, Ina Pieknik, Christian Casar, Dorothee Schwinge, Lara Henze, Günter K. Stalla, Undine E. Lang, Alina von Klitzing, Peer Briken, Thomas Hildebrandt, Jeanne C. Desbuleux, Sarah V. Biedermann, Paul-Martin Holterhus, Corinna Bang…
    Citation: BMC Medicine 2024 22:346
    Content type: Research Published on:

  24. Epidemiological evidence on weight change and atrial fibrillation (AF) remains limited and inconsistent. Previous studies on body mass index (BMI) in youth and AF rarely considered subsequent BMI. This study a...

    Authors: Yufeng Du, Lu Qi, Yan Borné and Emily Sonestedt
    Citation: BMC Medicine 2024 22:345
    Content type: Research Published on:

  25. The combination of anti-programmed death 1 (PD-1) inhibitors and tyrosine kinase inhibitors is an effective treatment strategy in endometrial cancer. We aimed to explore the efficacy and safety of camrelizumab...

    Authors: Wenjuan Tian, Yulan Ren, Jing Lu, Chuyu Jing, Wei Zhang, Haiming Li, Tingting Wang, Zhiguo Hou, Ting Yang, Wenqing Zhu, Yi Zhang, Boer Shan, Huijuan Yang, Xi Cheng and Huaying Wang
    Citation: BMC Medicine 2024 22:344
    Content type: Research Published on:

  26. Racial and ethnic disparities in mortality persist among US cancer survivors, with social determinants of health (SDoH) may have a significant impact on these disparities.

    Authors: Hongbo Huang, Tingting Wei, Ying Huang, Aijie Zhang, Heng Zhang, Ze Zhang, Yijing Xu, Haonan Pan, Lingquan Kong, Yunhai Li and Fan Li
    Citation: BMC Medicine 2024 22:343
    Content type: Research Published on:

  27. Early detection and treatment are effective methods for the management of oral squamous cell carcinoma (OSCC), which can be facilitated by the detection of tumor-specific OSCC biomarkers. The epidermal growth ...

    Authors: Nenghao Jin, Yu An, Yu Tian, Zeyu Zhang, Kunshan He, Chongwei Chi, Wei Mu, Jie Tian and Yang Du
    Citation: BMC Medicine 2024 22:342
    Content type: Research article Published on:

  28. Prominent product placement is a core promotional tactic in retail food environments. How this practice has been adapted for online supermarkets, and the extent to which it is applied to healthier and less hea...

    Authors: Damian Maganja, Madeleine de Carle, Tazman Davies, Clara Gómez Donoso, Tailane Scapin, Adrian J. Cameron, Jimmy C. Y. Louie, Mark D. Huffman, Kathy Trieu and Jason H. Y. Wu
    Citation: BMC Medicine 2024 22:341
    Content type: Research article Published on:

  29. Increasing consumption of ultra-processed foods (UPF) has been identified as a risk factor for obesity and various diseases, primarily in adults. Nonetheless, research in children is limited, especially regard...

    Authors: Camila Zancheta, Natalia Rebolledo, Lindsey Smith Taillie, Marcela Reyes and Camila Corvalán
    Citation: BMC Medicine 2024 22:340
    Content type: Research article Published on:

  30. Pregnancy complications might lead to the development of autoimmune diseases in women. This review aims to summarise studies evaluating the association between pregnancy complications and the development of au...

    Authors: Megha Singh, Fathima Fazla Ahamed Fayaz, Jingya Wang, Steven Wambua, Anuradha Subramanian, John A. Reynolds, Krishnarajah Nirantharakumar and Francesca Crowe
    Citation: BMC Medicine 2024 22:339
    Content type: Review Published on:

  31. Antenatal steroid therapy for fetal lung maturation is routinely administered to women at risk of preterm delivery. There is strong evidence to demonstrate benefit from antenatal steroids in terms of survival ...

    Authors: Sean W. D. Carter, Erin L. Fee, Haruo Usuda, Gokce Oguz, Adaikalavan Ramasamy, Zubair Amin, Biswas Agnihotri, Qin Wei, Liu Xiawen, Tsukasa Takahashi, Yuki Takahashi, Hideyuki Ikeda, Yusaku Kumagai, Yuya Saito, Masatoshi Saito, Citra Mattar…
    Citation: BMC Medicine 2024 22:338
    Content type: Research Published on:

  33. Dietary guidelines recommend a shift to plant-based diets. Fortified soymilk, a prototypical plant protein food used in the transition to plant-based diets, usually contains added sugars to match the sweetness...

    Authors: M. N. Erlich, D. Ghidanac, S. Blanco Mejia, T. A. Khan, L. Chiavaroli, A. Zurbau, S. Ayoub-Charette, A. Almneni, M. Messina, L. A. Leiter, R. P. Bazinet, D. J. A. Jenkins, C. W. C. Kendall and J. L. Sievenpiper
    Citation: BMC Medicine 2024 22:336
    Content type: Research article Published on:

  34. Concomitant use of clopidogrel and proton pump inhibitor (PPI) is common, but PPI may reduce the antiplatelet effects of clopidogrel in patients undergoing percutaneous coronary intervention (PCI). We evaluate...

    Authors: Ju Hyeon Kim, Soon Jun Hong, Jung-Joon Cha, Subin Lim, Hyung Joon Joo, Jae Hyoung Park, Cheol Woong Yu, Tae Hoon Ahn, Young-Hoon Jeong, Byeong-Keuk Kim, Kiyuk Chang, Yongwhi Park, Young Bin Song, Sung Gyun Ahn, Jung-Won Suh, Sang Yeub Lee…
    Citation: BMC Medicine 2024 22:335
    Content type: Research Published on:

  35. The allometric body shape index (ABSI) and hip index (HI), as well as multi-trait body shape phenotypes, have not yet been compared in their associations with inflammatory markers. The aim of this study was to...

    Authors: Esther M. González-Gil, Laia Peruchet-Noray, Anja M. Sedlmeier, Sofia Christakoudi, Carine Biessy, Anne-Sophie Navionis, Yahya Mahamat-Saleh, Rola F. Jaafar, Hansjörg Baurecht, Marcela Guevara, Pilar Amiano Etxezarreta, W. M. Monique Verschuren, Jolanda M. A. Boer, Anja Olsen, Anne Tjønneland, Vittorio Simeon…
    Citation: BMC Medicine 2024 22:334
    Content type: Research Published on:

  36. The Correa’s cascade, encompassing chronic non-atrophic gastritis, atrophic gastritis, intestinal metaplasia, and dysplasia, represents the well-recognized pathway for the development of non-cardia gastric can...

    Authors: Yawen Sun, Li Yin, Dariush Nasrollahzadeh Nesheli, Jingru Yu, Joar Franzén and Weimin Ye
    Citation: BMC Medicine 2024 22:333
    Content type: Research Published on:

  37. Type 2 diabetes is one of the most prevalent and preventable diseases worldwide and impulsivity, a psychological trait characterized by making quick decisions without forethought, has been suggested as a key f...

    Authors: Carlos Gómez-Martínez, Pauline Paolassini-Guesnier, Léopold Fezeu, Bernard Srour, Serge Hercberg, Mathilde Touvier, Nancy Babio, Jordi Salas-Salvadó and Sandrine Péneau
    Citation: BMC Medicine 2024 22:332
    Content type: Research article Published on:

  38. Chronic kidney disease (CKD) is a global public health problem with major human and economic consequences. Despite advances in clinical guidelines, classification systems and evidence-based treatments, CKD rem...

    Authors: Stuart Stewart, Philip A. Kalra, Tom Blakeman, Evangelos Kontopantelis, Howard Cranmer-Gordon and Smeeta Sinha
    Citation: BMC Medicine 2024 22:331
    Content type: Review Published on:

  39. Adverse childhood experiences (ACEs) have been implicated in the aetiology of a range of health outcomes, including multimorbidity. In this systematic review and meta-analysis, we aimed to identify, synthesise...

    Authors: Dhaneesha N. S. Senaratne, Bhushan Thakkar, Blair H. Smith, Tim G. Hales, Louise Marryat and Lesley A. Colvin
    Citation: BMC Medicine 2024 22:315
    Content type: Research article Published on:

  40. Data have shown that vitamin B12 has immunomodulatory effects via different pathways, which could influence the pathophysiology of sepsis. The objective of this study was to investigate whether vitamin B12 lev...

    Authors: Andreas Pregernig, Ulrike Held, Martin Schläpfer and Beatrice Beck-Schimmer
    Citation: BMC Medicine 2024 22:330
    Content type: Research article Published on:

  41. Hypersensitivity reactions (HSRs) can occur unexpectedly and be life-threatening when gadolinium-based contrast agents (GBCAs) are used. Gadolinium deposition disease (GDD) and symptoms associated with gadolin...

    Authors: Han Qu, Wenjing Li, Zhenghua Wu, Yuanyuan Wang, Tingting Feng, Nianyun Li, Chendong Qi, Xiang Li, Taishan Wei, Guorong Fan and Yuefen Lou
    Citation: BMC Medicine 2024 22:329
    Content type: Research article Published on:

  42. Mothers play a crucial role in influencing their daughters’ HPV vaccination decisions. Addressing barriers to receiving HPV vaccination among mothers of girls may achieve two goals in one strike: increasing va...

    Authors: Zian Lin, Siyu Chen, Lixian Su, Yuxue Liao, Hongbiao Chen, Zhiqing Hu, Zhuolin Chen, Yuan Fang, Xue Liang, Jianan Chen, Biyun Luo, Chuanan Wu and Zixin Wang
    Citation: BMC Medicine 2024 22:328
    Content type: Research Published on:

  43. Cervical cancer incidence is rising in Puerto Rico (PR). Whether the increase is real or reflective of increased diagnostic scrutiny remains unclear.

    Authors: Ana P. Ortiz, Carlos R. Torres-Cintrón, Eduardo J. Santiago-Rodríguez, Jeslie M. Ramos-Cartagena, Tonatiuh Suárez-Ramos, Haluk Damgacioglu, Vivian Colón-López, Karen J. Ortiz-Ortiz and Ashish A. Deshmukh
    Citation: BMC Medicine 2024 22:327
    Content type: Research Published on:

  44. The causal relationship between daytime napping and the risk of Parkinson’s disease (PD) remains unclear, with prospective studies providing limited evidence. This study investigated the association between da...

    Authors: Fabin Lin, Yisen Shi, Wenjing Song, Yanhong Weng, Xinyang Zou, Xuanjie Chen, Jiayi Zheng, Ke Chen, Qinyong Ye, Xilin Wu and Guoen Cai
    Citation: BMC Medicine 2024 22:326
    Content type: Research article Published on:

  45. Obesity has been linked to arterial stiffness, while no consensus was reached on the association. We aimed to clarify the association of general and central obesity with arterial stiffness by combining observa...

    Authors: Wuqing Huang, Zhaojing Gan, Ziting Gao, Qiaofen Lin, Xiaojiang Li, Wenhui Xie, Zesen Gao, Zhixian Zhou, Ziyi Qiu, Weihong Qiu, Shanshan Du, Liangwan Chen, Huashan Hong and Weimin Ye
    Citation: BMC Medicine 2024 22:325
    Content type: Research Published on:

  46. In recent years, the Middle East has witnessed a significant rise in commercial transplantation activities. This practice is driven by a multitude of factors including economic disparities, inadequate healthca...

    Authors: Reem M. Alameer, Ahmed A. Alhammadi, Yusri Taha, Talal Al Goufi and Reem S. Almaghrabi
    Citation: BMC Medicine 2024 22:322
    Content type: Debate Published on:

  47. Vitamin A is essential for physiological processes like vision and immunity. Vitamin A’s effect on gut microbiome composition, which affects absorption and metabolism of other vitamins, is still unknown. Here ...

    Authors: Ana M. Valdes, Panayiotis Louca, Alessia Visconti, Francesco Asnicar, Kate Bermingham, Ana Nogal, Kari Wong, Gregory A. Michelotti, Jonathan Wolf, Nicola Segata, Tim D. Spector, Sarah E. Berry, Mario Falchi and Cristina Menni
    Citation: BMC Medicine 2024 22:321
    Content type: Research Published on:

  48. Despite surgical and pharmacological interventions, endometriosis can recur. Reliable information regarding risk of recurrence following a first diagnosis is scant. The aim of this study was to examine clinica...

    Authors: Sarah J. Holdsworth-Carson, Jessica Chung, Dorothy A. Machalek, Rebecca Li, Byung Kyu Jun, Meaghan J. Griffiths, Molly Churchill, Tristan McCaughey, Debbie Nisbet, Uri Dior, Jacqueline F. Donoghue, Grant W. Montgomery, Charlotte Reddington, Jane E. Girling, Martin Healey and Peter A. W. Rogers
    Citation: BMC Medicine 2024 22:320
    Content type: Research Published on:

  49. This paper investigates the consequences of the COVID-19 pandemic on mortality and hospitalization among nursing home residents in Norway. While existing evidence shows that nursing home residents were overrep...

    Authors: Henning Øien, Jonas Gjesvik, Katrine Damgaard Skyrud, Torill Alise Rotevatn and Mari Grøsland
    Citation: BMC Medicine 2024 22:318
    Content type: Research article Published on:

  50. The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) serves as a novel composite lipid indicator for atherosclerosis. However, the association between NHHR and mort...

    Authors: Binyang Yu, Min Li, Zongliang Yu, Tao Zheng, Xue Feng, Anran Gao, Haoling Zhang and Rui Gao
    Citation: BMC Medicine 2024 22:317
    Content type: Research Published on:
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