Figure 3
Effect of catalase (CAT) overexpression on LeTx-induced generation of O 2 - and ROS. A: Representative images depicting DHE fluorescence in myocardium from WT and catalase transgenic mice treated with or without lethal toxin. B: Pooled data of O2 - production; C: Representative images depicting DCF fluorescence in myocardium from WT and catalase transgenic mice; and D: ROS levels in isolated cardiomyocytes from WT and catalase transgenic mice treated with or without lethal toxin. Mean ± SEM, n = 3 mice (panel B) or 6 isolations (panel D) per group, *P <0.05 vs. WT group, #P <0.05 vs. WT-LeTx group.