Table 1 Notch signaling in STS.
Tumor | Results | Notch componentinvolved | Role of Notch signaling | Reference |
|---|---|---|---|---|
Synovial sarcoma | Â | Notch1, JAG1 and TLEs over-expression | Pro-tumor | [33] |
| Â | Â | TLE1 over-expression | Pro-tumor | |
| Â | Prevents EGR1 expression Reduces apoptosis Promotes cell growth Favors epigenetic gene repression | TLE1 over-expression | Pro-tumor | [41] |
Ewing's sarcoma | Prevents differentiation Increases cell proliferation Decreases apoptosis Supports tumor growth in vivo | Manic Fringe expression Notch1 ICD over-expression | Onco-suppressor Regulates differentiation | [51] |
| Â | In p53 wild-type tumor cells: Induces p53 Blocks cell proliferation Inhibits soft agar colony formation | JAG1 and HEY1 down-regulated by EWS-FLI1 and Notch3 | Onco-suppressor | [52] |
| Â | Prevents cell proliferation | Notch1 and Notch3 | Onco-suppressor | [54] |
Rhabdomyosarcoma | Supports cell proliferation Inhibits apoptosis Prevents differentiation | HES1 over-expression in RMS primary samples and in cell lines | Pro-tumor | [68] |
| Â | Increases cell migration Increases cell invasion | Notch2 and HEY1 over-expressed in patients with alveolar RMS and embryonal RMS | Pro-tumor | [69] |
| Â | Increases cell proliferation Supports tumor growth in vivo | Notch1 ICD and HEY1 over-expressed in primary embryonal RMS and cell lines | Pro-tumor | [70] |
| Â | Prevents differentiation Supports cell proliferation Supports tumor growth in vivo | Notch3 ICD and HES1 over-expressed in alveolar RMS and embryonal RMS cell lines | Pro-tumor | [71] |
|  | Supports cell proliferation and anchorage-independence in vitro and tumor growth in vivo | RBP-Jκ over-expressed in embryonal RMS primary tissues and cell lines | Pro-tumor | [76] |