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Table 1 Characteristics of the T1D subjects before treatment

From: Reversal of type 1 diabetes via islet β cell regeneration following immune modulation by cord blood-derived multipotent stem cells

Patient No. Age Gender Marriage History (year) Height (cm) Body weight (kg) C-peptide (ng/ml)* Auto-Antibodies HbA1C (%) Insulin dose (U/day)
         IA-2A GAD ICA IAA   
Group A: Long-standing patients having some residual islet β cell function and received therapy with CB-SC
1 17 F No 5 145 35 0.30 - + - - 12.3 52
2 23 F No 5 167 59 0.56 - + - - 6.6 50
3 38 F Yes 11 160 60 0.12 - + - - 7.3 23
4 39 F Yes 1 156 49 0.636 + + + - 11.3 22
5 31 M Yes 14 170 70 0.18 + + - - 6.5 30
6 30 M Yes 2 182 70 0.18 - + - - 8.4 40
Mean (SD) 30 (9)    6 (5) 163 (12.7) 57 (13.4) 0.33 (0.22)      8.7 (2.5) 36.2 (13.2)
Group B: Long-standing severe patients with no residual islet b cell function and received therapy with CB-SC
7 40 M Yes 17 170 72.5 0.01 - + - - 8.8 48
8 15 F No 5 163 65 0.01 - + - - 15.5 50
9 21 F No 4 168 65 0.01 + - - - 9.9 46
10 23 F No 12 162 80 0.01 + + + - 16.5 60
11 40 F Yes 21 160 67 0.01 + - - - 8.6 37
12 21 F No 5 157 56 0.01 - + - - 13.6 50
Mean (SD) 27 (11)    11 (7) 163 (4.9) 67.6 (8.1) 0.01 (0)      12.2 (3.5) 48.5 (7.4)
Control group: Long-standing patients having some residual islet β cell function and received sham therapy
13 35 M Yes 1 178 73.5 0.37 + - + - 9.8 30
14 41 M Yes 14 165 65 0.55 - + - - 6.4 48
15 24 M No 3 175 58 0.3 - + - - 10.7 48
Mean (SD) 33 (9)    6 (7) 173 (6.8) 65.5 (7.8) 0.41 (0.13)      9.0 (2.3) 42 (10.4)
  1. *The level of 0.01 ng/ml is the minimum detectable level (sensitivity) of C-peptide by radioimmunoassay (RIA). To convert C-peptide value to nmol/L, multiply the ng/ml by 0.331.