Bioinformatic identification of proteins with tissue-specific expression for biomarker discovery

Table 2 Forty-eight proteins identified as tissue-specific, strongly expressed and secreted or shed in colon, lung, pancreatic or prostate tissue^a

Tissue	Gene	BioGPS [15, 16]	C-It [9]	HPA [20]	TiGER [11]	UniGene [13]	VeryGene [18]	Previously studied as a (tissue) cancer or benign disease serum biomarker [reference]
Colon	CEACAM7	√			√
	CLCA1	√			√	√
	GPA33			√	√
	LEFTY1	√			√
	ZG16	√			√
Lung	IRX5	√	√		√
	LAMP3				√		√
	MFAP4	√	√
	SCGB1A1	√			√		√
	SFTPA2	√					√	[54–56]
	SFTPB	√			√		√	[55]
	SFTPC			√	√
	SFTPD	√			√		√	[56]
	TMEM100	√	√				√
Pancreas	AQP8	√					√
	CEL	√			√		√	[60]
	CELA2A					√	√	[61]
	CELA2B	√	√			√	√
	CELA3B	√				√
	CPA1	√		√	√	√	√	[62]
	CPA2	√		√	√		√	[62]
	CPB1	√			√	√	√	[63]
	CTRB1	√			√
	CTRB2	√	√			√
	CTRC	√			√		√
	CUZD1		√		√		√
	GCG				√	√	√
	IAPP				√	√	√
	INS			√	√		√
	KLK1	√			√		√
	PNLIP	√			√	√	√	[64]
	PNLIPRP1		√		√		√
	PNLIPRP2	√			√		√
	PPY				√	√	√
	PRSS1	√		√	√	√	√	[65]
	PRSS3				√		√
	REG1B				√	√	√
	REG3G		√		√		√
	SLC30A8				√	√	√
	SYCN	√	√		√	√	√	[33]
Prostate	ACPP	√		√	√	√	√	[66]
	FOLH1	√			√			[67]
	KLK2	√			√			[68]
	KLK3	√		√	√			[66]
	NPY				√		√
	PSCA	√			√
	RLN1	√			√	√	√
	SLC45A3	√		√	√		√

^aTissue-specific proteins as it applies to this table indicates protein expression was manually verified in BioGPS and/or HPA databases. HPA: Human Protein Atlas; TiGER: Tissue-specific and Gene Expression and Regulation.

ISSN: 1741-7015