Do hypnotics cause GERD? Daniel Kripke, UCSD 11 June 2012 The strong association of reported sleep disturbance with GERD is interesting. Gagliardi et al.  showed experimentally that zolpidem caused GERD. More recently, my colleagues and I  found an association of hypnotic usage with both esophageal-gastric complaints and esophageal cancer. Thus, it seems important to determine if hypnotics were the underlying cause of GERD associated with "inadequate sleep" in this study. Can the authors comment?  Gagliardi, G. S., Shah, A. P., Goldstein, M., Denua-Rivera, S., Doghramji, K., Cohen, S., and Dimarino, A. J., Jr. Effect of Zolpidem On the Sleep Arousal Response To Nocturnal Esophageal Acid Exposure. Clin Gastroenterol.Hepatol. 7(9), 948-952. 5-6-2009.  Kripke, D. F., Langer, R. D., and Kline, L. E. Hypnotics' association with mortality or cancer: a matched cohort study. BMJ Open. 2(1), e000850. 2012 and "Web Extra" data supplement. Competing interests None.