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Archived Comments for: Lifestyle factors affecting gastroesophageal reflux disease symptoms: a cross-sectional study of healthy 19864 adults using FSSG scores

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  1. Do hypnotics cause GERD?

    Daniel Kripke, UCSD

    11 June 2012

    The strong association of reported sleep disturbance with GERD is interesting. Gagliardi et al. [1] showed experimentally that zolpidem caused GERD. More recently, my colleagues and I [2] found an association of hypnotic usage with both esophageal-gastric complaints and esophageal cancer. Thus, it seems important to determine if hypnotics were the underlying cause of GERD associated with "inadequate sleep" in this study. Can the authors comment?

    [1] Gagliardi, G. S., Shah, A. P., Goldstein, M., Denua-Rivera, S., Doghramji, K., Cohen, S., and Dimarino, A. J., Jr. Effect of Zolpidem On the Sleep Arousal Response To Nocturnal Esophageal Acid Exposure. Clin Gastroenterol.Hepatol. 7(9), 948-952. 5-6-2009.

    [2] Kripke, D. F., Langer, R. D., and Kline, L. E. Hypnotics' association with mortality or cancer: a matched cohort study. BMJ Open. 2(1), e000850. 2012 and "Web Extra" data supplement.

    Competing interests