Author/year of publication | Study design | Laboratory technique | Number of patients |
Cut-off value (U/mL) | Trimester 1 | Trimester 2 | Trimester 3 | Conclusion | |
---|---|---|---|---|---|---|---|---|---|

1 | Niloff 1984 [12] | cross-sectional | 125I-labeled OC125 | N = 101 | <65 | >65 in 16% | < 65 | <65 | T1: 16% above cut-off value |

2 | Haga 1986 [13] | cross-sectional | Centocore Inc., Malvern, PA, USA | T1 n = 29; T2 n = 21; T3 n = 21 | <35 |
85 ± 101 (mean ± SD) 18 to 550 (range) |
20 ± 10 10 to 54 |
25 ± 27 <8 to 140 | Raised above cut-off value, percentage not stated |

3 | Jacobs 1988 [14] | cross-sectional | Abbott Laboratories, Chicago, IL, USA | T1 n = 11; T2 n = 7; T3 n = 8 | <35 |
53.6 (median) 15.6 to 268.3 (range) |
18.5 12.0 to 25.1 |
19.2 16.8 to 43.8 | 35% above cut-off value |

4 | Kobayashi 1989 [15] | both cross-sectional and longitudinal | ORIS Industry, Censaclay, France | n = 122 | <35 |
71.7 ± 71.1 (mean ± SD) | 19.1 ± 7.0 | 28.1 ±14.1 | Raised above cut-off value, percentage not stated |

5 | Touitou 1989 [16] | cross-sectional | IRMA, CIS-Bio International, Gif-Sur-Yvette, France | T1 n = 32; T2 n = 32; T3 n= 36 | <35 |
23.7± 13.9 (mean ± SD) | 14.8 ± 8.0 | 22.1 ± 17.1 | 8% above cut-off value |

6 | Kenemans 1992 [17] | cross-sectional | Enzymun CA 125 (Boehringer, Mannheim, Germany) | T1 n = 26; T2 n = 20; T3 n = 145 | <35 |
24.4 ± 13.3 (mean ± SD) 54.6 (maximum range) |
38.1 ± 47.4 166.6 |
74.7 ± 273.3 2,419.7 |
T1: 19% above cut-off value T2: 15% above cut-off value T3: 20% above cut-off value |

7 | Schlageter 1998 [7] | longitudinal | ELSA-CA 125 (CIS Bio International-Bio International, Gif-Sur-Yvette, France | n = 12 | <40 |
18.7 ± 14.0 (mean ± SD) 6.1 to 41.5 (range) |
19.9 ± 12.5 6.5 to 54.3 |
22.3 ± 13.1 6.1 to 51.3 | Raised above cut-off value, percentage not stated |

8 | Spitzer 1998 [18] | longitudinal | Centocore Inc., Diagnostic division, Malvern, PA, USA | n = 20 | <35 |
33.1 (median) 3.7 to 251.2 (range) | <35 | <35 | Raised above cut-off value, percentage not stated |

9 | Bon 2001 [10] | cross-sectional | Enzymun-Test CA 125 (Boehringer, Mannheim, Germany) | T1 n = 127; T2 n = 192; T3 n = 47 | Not stated |
23 (median) 4 to 108 (range) |
14 1 to 73 |
21 8 to 144 | Raised above cut-off value, percentage not stated |

10 | Ercan 2012 [11] | longitudinal | Modular Analytics E 170 Module (Roche diagnostics, Basel, Switserland | n = 30 | <35 |
19.0 (median) 4.9 to 61 (range) |
15.6 4.7 to 32.1 |
19.6 9.8 to 41.2 | 4.4% above cut-off value |