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Table 3 Univariate analysis of 30-day outcome of ICH among patients with hematological malignancies.

From: Intracranial hemorrhage in adult patients with hematological malignancies

  Alive (n = 26) Dead (n = 46) Univariate analysis, Pvalue Multivariate analysis, Pvalue (odds ratio; 95% CI)
Gender:    0.604  
Male 16 32   
Female 10 14   
Age    >0.999  
≥60 years 12 20   
<60 years 14 26   
Hematological malignancies    0.679  
AML 14 29   
APL 5 4   
ALL 2 3   
Lymphoma 3 4   
Myeloma 2 6   
Remission status    0.448  
Yes 4 4   
No 22 42   
Post HSCT    0.473  
Yes 2 7   
No 24 39   
Underlying hypertension    >0.999  
Yes 7 12   
No 19 34   
Sepsis    0.050  
Yes 8 26   
No 18 20   
CNS involvement    >0.999  
Yes 2 4   
No 24 42   
Subarachnoid hemorrhage    0.007 0.021 (10.9; 1.3 to 88.9)
Yes 1 14   
No 25 32   
Multifocal hemorrhage    0.006 0.026 (4.7; 1.6 to 14.0)
Yes 6 27   
No 20 19   
Surgical intervention    0.085  
Yes 7 4   
No 19 41   
Leukocyte count    >0.999  
≥100,000 cells/μl 4 8   
<100,000 cells/μl 22 38   
Platelet count    0.802  
≥20,000 cells/μl 16 30   
<20,000 cells/μl 10 16   
Prolongation of prothrombin time    0.013 0.008 (10.9; 1.3 to 85.5)
INR ≥1.5 1 14   
INR <1.5 24 32   
  1. ALL = acute lymphoblastic leukemia; AML = acute myeloid leukemia; APL = acute promyelocytic leukemia; CNS = central nervous system; HSCT = hematopoietic stem cell transplantation; ICH = intracranial hemorrhage; INR = international normalized ratio.