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Table 3 Prevalence of high risk conditions among RV hospitalizations and their association with disease outcome and healthcare utilization

From: Targeted rotavirus vaccination of high-risk infants; a low cost and highly cost-effective alternative to universal vaccination

  Prevalence P-valueb RRb
   Observational study Weighted estimates national RV hospitalizations (95% CI) General infant populationa   
High Risk Conditions % N % N % N   
GA < 36 weeks 8.9 83 6.8 (5.1; 8.5) 347 ( 243; 451) 4.3 7617 0.005 1.7 (1.2; 2.8)
LBW 11.1 104 8.8 (6.6; 11.1) 462 (309; 615) 6.0 10545 0.014 1.6 (1.1; 2.3)
Congenital pathology 12.4 116 6.2 (4.9; 7.4) 309 (244; 374) 1.5 2719 <0.0001 4.4 (3.4; 5.4)
  Healthy (N = 657)   High risk conditions
    GA <36 weeks (N = 83) LBW (N = 104) Congenital pathology (N = 116)
Outcome and healthcare utilization N (%)   N (%) RR (95% CI) N (%) RR (95% CI) N (%) RR (95% CI)
ICU admission 4 (0.6%)   4 (4.8%) 7.9 (2.0; 31.1) 3 (2.9%) 4.7 (1.1; 20.9) 3 (2.6%) 4.2 (1.0; 18.7)
RV related death (number,%) 0   0   0   2 (1.7%) NA
     Mean difference (95% CI)   Mean difference (95% CI)   Mean difference (95% CI)
LOS (mean, SD) 3.6 (2.1)   5.2 (4.7) +1.6 (0.1; 3.0) 5.1 (4.5) +1.5 (0.3; 2.7) 6.6 (4.2) +3.0 (1.9; 4.1)
Healthcare costs (mean, SD) 2,203 (2,113)   3,001 (3,407) +798 (28; 1,568) 2,851 (3,206) +648 (−2; 1,297) 3,737 (3,500) +1,533 (867; 2,199)
  1. aDutch birth cohort alive after one month, 2005-200838; bComparing weighted RV hospitalizations prevalence to population prevalence.
  2. GA: gestational age; LBW: low birth weight; LOS, length of stay; RR, relative risk; RV, rotavirus; SD: standard deviation.
  3. The figures in bold indicate the results of calculations form other columns in the table and represent the main findings.