Mitochondrial reactive oxygen species generation in patients with inflammatory bowel disease. (A) Intracellular H2O2 and mitochondrial peroxynitrate levels in mononuclear cells of patients with IBD before (IBD untr) and after treatment (IBD treat), compared with healthy volunteers (cont). Results are expressed as means ±SE. *P <0.003, **P <0.001. (B) Western blotting analysis of the expression patterns of various mtETC complex subunits from mitochondria isolated from peripheral blood MNC of patients. pat – patient. IBD, inflammatory bowel disease; mtETC, mitochondrial electron transport chain; MNC, mononuclear cells.