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Figure 2 | BMC Medicine

Figure 2

From: What is next after the genes for autoimmunity?

Figure 2

Weighted list created from the reported significant mapped genes in the current genome-wide association studies curated from the National Human Genome Research Institute and the database of genotypes and phenotypes. The word cloud shows the frequency of genes and its associated variants relative to their font size using a freely available java applet [24]. Both databases (accessed April 2013) [25, 26] were queried taking into account P-values reported for the genetic variants associated with autoimmune disease. For the National Human Genome Research Institute, a total of 12,064 genetic variants were encountered, out of which 1,370 were variants significantly associated with autoimmune disease susceptibility. In the database of genotypes and phenotypes, out of 31,246 reported variants, 972 were mutually exclusive from the National Human Genome Research Institute, for a grand total of 2,342 genetic variants related to genes associated in a genome-wide association study of any population. The autoimmune diseases of interest were autoimmune thyroid disease, Behcet’s disease, celiac disease, rheumatoid arthritis, inflammatory bowel disease, juvenile rheumatoid arthritis, Kawasaki disease, multiple sclerosis, primary biliary cirrhosis, primary sclerosing cholangitis, psoriasis, systemic sclerosis, systemic lupus erythematosus, type 1 diabetes and vitiligo.

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