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Table 4 Risk of developing depression stratified by level of adherence to Mediterranean diet (per-protocol analysis) after 3 years of follow-up

From: Mediterranean dietary pattern and depression: the PREDIMED randomized trial

  Adherence to MD
  Low: <8 points Medium: 8–9 points High: ≥10 points P-value for trend
Median (points) 7 9 11  
Cases, n 14 32 81  
Person-years 1,105 3,059 8,872
Model 1     
  HR (95% CI) 1 (ref) 0.81 (0.43 to 1.51) 0.72 (0.40 to 1.28) 0.26
Model 2     
  HR (95% CI) 1 (ref) 0.73 (0.38 to 1.39) 0.71 (0.38 to 1.32) 0.38
  1. Abbreviations: HR hazard ratio, MD Mediterranean diet, ref reference.
  2. Model 1: adjusted for age, sex, and recruiting center.
  3. Model 2: model 1 additionally adjusted for intervention group, for smoking, educational level, marital status, and the presence of any of several diseases at baseline, and body mass index, physical activity during leisure time, alcohol intake (except wine), and total energy intake after 3 years of follow-up.