Table 3 Medicines course frequency administered, implicated and off-label, unlicensed or unknown (only medicines with > 100 courses shown, n = 7,007)
| Â | Medicine (number of courses) | Number of courses off-label or unlicensed (%)a | Number of authorized courses implicated in at least one PD ADR (%) | Number of off-label or unlicensed courses implicated in at least one PD ADR (%) | Number of courses unknown |
|---|---|---|---|---|---|
Medicines with only authorized courses | Cefuroxime (245) | 0 (0%) | 15 (6.5%) | - | 1 |
Cefotaxime (388) | 0 (0%) | 40 (10.3%) | - | 0 | |
Medicines with off-label courses | Chlorphenamine (339) | 1 (0.3%) | 1 (0.3%) | 0 | 1 |
Diazepam (107) | 1 (1.9%) | 1 (1.0%) | 0 | 0 | |
Ibuprofen (545) | 26 (4.8%) | 4 (0.8%) | 1 (3.8%) | 0 | |
Lactulose (272) | 13 (4.8%) | 7 (2.7%) | 1 (0.1%) | 0 | |
Cefalexin (148) | 9 (6.1%) | 8 (5.8%) | 1 (11.0%) | 0 | |
Metronidazole (257) | 21 (8.2%) | 19 (8.0%) | 3 (14.3%) | 0 | |
Furosemide (110) | 13 (11.8%) | 13 (13.4%) | 2 (15.4%) | 0 | |
Paracetamol (1786) | 596 (33.4%) | 1 (0.1%) | 0 (0%) | 2 | |
Ondansetron (550) | 290 (52.7%) | 18 (8.5%) | 14 (2.5%) | 48 | |
Salbutamol (146) | 84 (57.5%) | 3(4.8%) | 10 (11.9%) | 0 | |
Ranitidine (109) | 65 (59.6%) | 1 (2.3%) | 0 (0%) | 0 | |
Dexamethasone (166) | 107 (64.5%) | 7(13.5%) | 3 (2.8%) | 7 | |
Fentanyl (150) | 149 (99.3%) | 0 (0%) | 72 (48%) | 0 | |
Medicines with unlicensed courses | Fentanyl and Levobupivicaine epidural (106) | 106 (100.0%) | - | 47 (44.3%) | 0 |
Medicines with off-label and unlicensed courses | Codeine Phosphate (752) | 12 (1.6%) | 49 (10.1%) | 0 (0%) | 257 |
Morphine (500) | 198 (39.8%) | 86 (28.5%) | 89 (44.9%) | 0 | |
Diclofenac (331) | 149 (45.0%) | 2 (8.7%) | 3 (2.0%) | 159 |