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Table 4 Impact of co-trimoxazole prophylaxis on mortality among predominately adult patients with HIV-associated tuberculosis (TB)

From: Management of HIV-associated tuberculosis in resource-limited settings: a state-of-the-art review

Study Year of publication Study design Country Level of bacterial resistance to co-trimoxazole No. of study participants Mortality reduction
Wiktor et al. [40] 1999 Randomized controlled trial Cote D’Ivoire Low 771 46%
Zachariah et al. [41] 2003 Cohort study (‘before’ and ‘after’ study with historical controls) Malawi (north) High 1,986 19%
Mwaungulu et al. [42] 2004 Cohort study (‘before’ and ‘after’ study with historical controls) Malawi (south) High 717 22%
Grimwade et al. [43] 2005 Cohort study (‘before’ and ‘after’ study with historical controls) South Africa High 3,325 29%
Nunn et al. [44] 2008 Randomized controlled trial Zambia High 1,003 21%