From: Depression pathogenesis and treatment: what can we learn from blood mRNA expression?
Citation | Type of study | Sample | Gene | Clinical assessments | Main findings |
---|---|---|---|---|---|
Pandey et al. 2010 [45] | Case-control | 25 adult MDD 25 adult controls 14 pediatric MDD 14 pediatric controls | BDNF | Diagnosis based on DSM-IV criteria HDRS CARS-M CDRS YMRS | Lower expression of BDNF in both adult and pediatric patients with MDD compared with controls. Lower protein levels of BDNF in both adult and pediatric patients with MDD compared with controls. |
Cattaneo et al. 2010a [46] | Case-control and follow up | 21 MDD 23 Controls | BDNF | Diagnosis based on DSM-IV or ICD-10 criteria MADRS | Lower expression of BDNF in patients with MDD compared with controls. Significant increase in expression of BDNF after escitalopram treatment as well as symptom improvement. |
Cattaneo et al. 2010b [48] | Case-control and follow up | 25 MDD 25 Controls | VGF | Diagnosis based on DSM-IV or ICD-10 criteria MADRS | Lower expression of VGF in patients with MDD compared with controls. Significant increase in expression of VGF after 12 weeks of escitalopram treatment in responders only. |
Cattaneo et al. 2012 [23] | Case-control and follow up | 74 MDD 34 Controls | BDNF VGF | Diagnosis based on DSM-IV or ICD-10 criteria SCAN | Lower expression of BDNF and VGF in patients with MDD compared with controls. Significant increase in BDNF and VGF expression after 8 weeks of antidepressant treatment (escitalopram or nortriptyline) in responders only. |
Otsuki et al. 2008 [49] | Case-control | 60 MDD 42 BPD 28 Controls | BDNF NGF NT-3 NT-4 GDNF ARTN NRTN PSPN | Diagnosis based on DSM-IV criteria HDRS | Lower expression of GDNF, ARTN and NT-3 in patients with MDD in a current depressive state compared with those in remission and controls. No significant difference in expression of GDNF, ARTN or NT-3 in patients with BPD. No significant difference in expression levels of BDNF, NGF or NT-3 among the three groups. |
Su et al. 2009 [54] | Case-control | 16 MDD 14 Controls | p11 | Diagnosis based on DSM-IV criteria MINI HAM-D HARS | Higher expression of p11 in patients with MDD compared with controls. |
Zhang et al. 2011 [55] | Case-control | 38 BPD 14 Controls | p11 | Diagnosis based on DSM-IV criteria MINI HDRS-17 YMRS | Higher expression of p11 in patients with BPD compared with controls. |
Iga et al. 2007 [57] | Case-control | 42 MDD 32 Controls | VEGF | Diagnosis based on DSM-IV criteria SIGH-D 17 | Higher expression of VEGF in patients with MDD compared to controls. |
Dome et al. 2009 [58] | Case-control | 33 MDD 16 Controls | CD34 CD133 VEGFR2 | Diagnosis based on DSM-IV criteria BDI | Lower expression of VEGFR2 and CD133 in patients with MDD compared with controls. Expression of VEGFR2 and CD133 correlated negatively with BDI scores. |
Anitha et al. 2008 [59] | Case-control | 33 MDD 21 BPD 57 Controls | PCNT2 | Diagnosis based on DSM-IV criteria BPRS HAM-D | Higher expression of PCNT2 in patients with MDD compared with controls. Higher expression of PCNT2 in patients with BPD in a remission state compared with controls. |
Nakataki et al. 2011 [60] | Case-control | 27 MDD 27 Controls | EMP1 | Diagnosis based on DSM-IV criteria HAM-D | Lower expression of EMP1 in patients with MDD compared with controls. A trend increase in expression of EMP1 after 8 weeks of antidepressant treatment |
Wakabayashi et al. 2008 [64] | Case-control | 60 MDD 42 BPD 28 Controls | NCAM-140 L1 VCAM-1 ICAM-1 E-cadherin | Diagnosis based on DSM-IV criteria HDRS | Lower expression of NCAM-140 in patients with BPD in a current depressive state, but not in a remissive state, compared with controls and patients with MDD. Higher expression of L1 in patients with BPD in a current depressive state, but not in a remissive state, compared with controls and patients with MDD. No significant differences in expression of NCAM-140 or L1 in patients with MDD compared with controls. No significant differences in expression of ICAM-1, VCAM-1 or E-cadherin in patients with MDD or BPD in a current depressive state compared to controls. |
Otsuki et al. 2010 [68] | Case-control | 60 MDD 46 BPD 28 Controls | REST CRH 5-HT1A Adcy5 CaMKIIa Epor IGF1R Tnfsf10 Tnfsf11 Tnfsf12-12 | Diagnosis based on DSM-IV criteria HDRS | Lower expression of REST in patients with MDD compared with controls. Higher expression of CRH, Adcy5 and Tnfsf12-13 in patients with MDD in a current depressive state compared with those in a remissive state. No significant difference in expression of REST or any other mRNAs in patients with BPD compared with controls. |