Figure 2

Change from baseline in (A) glycated hemoglobin (HbA1c), (B) urinary glucose:creatinine ratio, and (C) body weight for placebo (circles), dapagliflozin 2.5 mg (squares), dapagliflozin 5 mg (triangles), and dapagliflozin 10 mg (diamonds) groups all plus metformin up to 102 weeks. Data are means (95% CI) obtained from longitudinal repeated measures analyses. Data for HbA1c exclude patients who received rescue therapy to achieve the strict HbA1c requirements to remain in the trial. The urinary glucose:creatinine ratios also exclude patients who received rescue therapy. Data for weight, however, include patients who received rescue therapy (pioglitazone), demonstrating the ability of dapagliflozin to attenuate weight gain by this antidiabetes medication. Mean change from baseline in HbA1c after adjustment for baseline value (A), mean change from baseline in urinary glucose:creatinine ratio (g/g) after adjustment for baseline value (B) and mean change from baseline in body weight after adjustment for baseline value (C) are shown.