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Table 4 Plasma adrenocorticotropic hormone (ACTH) (pmol/l) and cortisol (nmol/l) tertiles and obesity comorbidities in logistic regression.

From: High-end normal adrenocorticotropic hormone and cortisol levels are associated with specific cardiovascular risk factors in pediatric obesity: a cross-sectional study

Factor Tertile ACTH Cortisol
   OR 95% CI Pvalue OR 95% CI Pvalue
Hypertension I 1.000    1.000   
  II 1.088 0.661 to 1.821 0.719 1.071 0.646 to 1.778 0.789
  III 1.907 1.107 to 3.286 <0.02 1.721 1.008 to 2.913 <0.04
HDL <10° percentile I 1.000    1.000   
  II 1.433 0.884 to 2.323 0.145 0.866 0.549 to 1.429 0.619
  III 1.439 0.886 to 2.338 0.141 1.993 0.610 to 1.614 0.976
TG >90° percentile I 1.000    1.000   
  II 1.182 0.631 to 2.212 0.601 0.981 0.545 to 1.768 0.950
  III 2.367 1.319 to 4.248 <0.004 1.410 0.798 to 1.491 0.237
LDL >90° percentile I 1.000    1.000   
  II 2.181 0.655 to 7.263 0.204 2.520 0.676 to 7.490 0.186
  III 3.098 0.973 to 9.866 0.056 3.223 1.012 to 10.265 <0.04
Dysglycemia I 1.000    1.000   
  II 1.659 0.632 to 4.356 0.304 1.161 0.484 to 2.788 0.738
  III 2.959 1.198 to 7.307 <0.01 1.699 0.740 to 3.900 0.211
Hypertensiona I 1.000    1.000   
  II 1.033 0.603 to 1.769 0.906 1.042 0.607 to 1.790 0.882
  III 1.668 0.978 to 2.966 0.072 1.593 1.002 to 3.133 <0.04
HDL <10° percentilea I 1.000    1.000   
  II 1.287 0.771 to 2.148 0.335 0.817 0.489 to 1.365 0.440
  III 1.090 0.649 to 1.832 0.745 0.868 0.514 to 1.467 0.598
TG >90° percentilea I 1.000    1.000   
  III 1.050 0.546 to 2.019 0.884 1.075 0.578 to 2.000 0.819
  III 2.118 1.139 to 3.939 <0.01 1.559 0.851 to 2.856 0.150
LDL >90° percentilea I 1.000    1.000   
  II 2.279 0.678 to 7.665 0.183 2.286 0.678 to 7.725 0.183
  III 3.179 0.975 to10.365 0.055 3.546 1.095 to 11.490 <0.03
Dysglycemiaa I 1.000    1.000   
  II 1.582 0.593 to 4.217 0.359 1.040 0.421 to 2.570 0.932
  III 2.548 1.003 to 6.475 <0.04 1.516 0.641 to 3.585 0.344
  1. Values in bold represent significant results. Hypertension was considered as >95° percentile. aAdjusted for gender, age, Tanner stage, and BMI. ACTH tertiles were subdivided as: I = <3.54 pmol/l; II = 3.54 to 5.92 pmol/l; III = >5.92 pmol/l. Cortisol tertiles were subdivided as: I = <240.0 nmol/l; II = 240.0 to 383.5 nmol/l; III = >383.5nmol/l. BMI = body mass index; CI = confidence interval; HDL = high-density lipoprotein; LDL = low-density lipoprotein; OR = odds ratio; TG = triglycerides.